學術論文


Academic papers

抗發炎

論文出處:Food Chem Toxicol. 2014 Jul;69:150-62. doi: 10.1016/j.fct.2014.04.006. Epub 2014 Apr 18.

論文名稱:Antrodia cinnamomea profoundly exalted the reversion of activated hepatic stellate cells by the alteration of cellular proteins.

作  者:Chen YR, Chang KT, Tsai MJ, Lee CH, Huang KJ, Cheng H, Ho YP, Chen JC, Yang HH, Weng CF

出 版 年:2014

分  類:抗發炎

論文結論:Antrodia cinnamomea mycelial extract (ACME) could improve liver morphology and histological changes including collagen formation and GPT activity in the liver of thioacetamide (TAA)-injured rats.

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論文出處:Int J Radiat Biol. 2014 Oct;90(10):841-52. doi: 10.3109/09553002.2014.911989. Epub 2014 Aug 11.

論文名稱:Radioprotective effects of Antrodia cinnamomea are enhanced on immune cells and inhibited on cancer cells.

作  者:Cheng PC, Huang CC, Chiang PF, Lin CN, Li LL, Lee TW, Lin B, Chen IC, Chang KW, Fan CK, Luo TY.

出 版 年:2014

分  類:抗發炎

論文結論:Antrodia cinnamomea (AC) may inhibit important immunoregulatory signaling which could be vital in the avoidance of an over-activated cytotoxic and inflammatory response of the immune system caused by radiation-induced tissue damage. AC does not provide a radioprotective effect to tumor cells but instead enhances radiation-induced inflammation and cytotoxicity in cancer.

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論文出處:PLoS One. 2014 Apr 1;9(4):e93191. doi: 10.1371/journal.pone.0093191. eCollection 2014.

論文名稱:Hepatoprotective bioactivity of the glycoprotein, antrodan, isolated from Antrodia cinnamomea mycelia.

作  者:Ker YB, Peng CC, Chang WL, Chyau CC, Peng RY

出 版 年:2014

分  類:抗發炎

論文結論:Antrodan, a polysaccharide isolated from mycelia of Antrodia cinnamomea, can potentially ameliorate liver damage in vivo by suppressing oxidative stress induced by LPS.

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論文出處:Biochem Pharmacol. 2014 Sep 15;91(2):217-30. doi: 10.1016/j.bcp.2014.06.026. Epub 2014 Jul 27.

論文名稱:Zhankuic acid A as a novel JAK2 inhibitor for the treatment of concanavalin A-induced hepatitis.

作  者:Chen YF, Wang SH, Chang SJ, Shiau AL, Her LS, Shieh GS, Chen CF, Chang CC, Su YC, Wu CL, Wu TS

出 版 年:2014

分  類:抗發炎

論文結論:Zhankuic acid A (ZAA), a major pharmacologically active compound, can inhibit JAK2 phosphorylation and protect against liver injury during acute hepatitis in mice.

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論文出處:J Immunol. 2014 Mar 15;192(6):2778-86. doi: 10.4049/jimmunol.1301931. Epub 2014 Feb 14.

論文名稱:Zhankuic acid A isolated from Taiwanofungus camphoratus is a novel selective TLR4/MD-2 antagonist with anti-inflammatory properties.

作  者:Chen YF, Shiau AL, Wang SH, Yang JS, Chang SJ, Wu CL, Wu TS.

出 版 年:2014

分  類:抗發炎

論文結論:Zhankuic acid A (ZAA), a major pharmacologically active compound of Taiwanofungus camphoratus, which can compete with LPS for binding to MD-2 as a TLR4/MD-2 antagonist, may be a potential therapeutic agent for gram-negative bacterial infections.

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論文出處:ScientificWorldJournal. 2014;2014:745802. doi: 10.1155/2014/745802. Epub 2014 Oct 14.

論文名稱:Effect of Antrodia camphorata on inflammatory arterial thrombosis-mediated platelet activation: the pivotal role of protein kinase C.

作  者:Lu WJ, Lin SC, Lan CC, Lee TY, Hsia CH, Huang YK, Lee HC, Sheu JR

出 版 年:2014

分  類:抗發炎

論文結論:Antrodia camphorata may inhibit platelet activation by inhibiting of Ca2+ and PKC cascade and the Akt pathway. That may be a potential therapeutic agent for preventing or treating thromboembolic disorders.

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論文出處:Phytomedicine. 2014 Oct 15;21(12):1708-16. doi: 10.1016/j.phymed.2014.08.011. Epub 2014 Sep 16.

論文名稱:Comparison of solid-state-cultured and wood-cultured Antrodia camphorata in anti-inflammatory effects using NF-κB/luciferase inducible transgenic mice.

作  者:Tung YT, Tsai TC, Kuo YH, Yen CC, Sun JY, Chang WH, Chen HL, Chen CM

出 版 年:2014

分  類:抗發炎

論文結論:Methanolic extracts both of solid-state-cultured AC (S-AC) and wood-cultured AC (W-AC) have excellent anti-inflammatory activities.

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論文出處:Int J Med Mushrooms. 2014;16(1):95-103.

論文名稱:Immunomodulatory effect of polysaccharides extracted from the medicinal mushroom Antrodia camphorata (higher Basidiomycetes) in specific pathogen-free chickens.

作  者:Song AR, Qin D, Zhao C, Sun XL, Huang F, Kong C, Yang S

出 版 年:2014

分  類:抗發炎

論文結論:Antrodia camphorata extract (ACE) could enhance the immune functions of the organs in specific pathogen-free (SPF) chickens and could be an attractive application of nutraceuticals and pharmaceuticals.

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論文出處:J Agric Food Chem. 2014 Jun 11;62(23):5321-9. doi: 10.1021/jf405113g. Epub 2014 May 29.

論文名稱:Methanol extract of Antrodia camphorata protects against lipopolysaccharide-induced acute lung injury by suppressing NF-κB and MAPK pathways in mice.

作  者:Huang GJ, Deng JS, Chen CC, Huang CJ, Sung PJ, Huang SS, Kuo YH.

出 版 年:2014

分  類:抗發炎

論文結論:Pretreatment with the methanol extract of Antrodia camphorata (MAC) markedly improved LPS-induced histological alterations and edema in lung tissues. Utilize the NF-κB and MAPKs pathways and the regulation of SOD activity to attenuate LPS-induced nonspecific pulmonary inflammation.

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論文出處:Am J Chin Med. 2015;43(7):1401-17. doi: 10.1142/S0192415X15500792. Epub 2015 Oct 18.

論文名稱:Antrodia cinnamomea Extract Inhibits Th17 Cell Differentiation and Ameliorates Imiquimod-Induced Psoriasiform Skin Inflammation.

作  者:Li MH, Wu HC, Yao HJ, Lin CC, Wen SF, Pan IH

出 版 年:2015

分  類:抗發炎

論文結論:Antrodia cinnamomea extract (AC) inhibited the differentiation of Th17 cells as well as the production of IL-17A, IL-21, and IL-22 from these cells. This effect was associated with the inhibition of STAT3 phosphorylation and RORγt expression.

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論文出處:PLoS One. 2015 Feb 27;10(2):e0116191. doi: 10.1371/journal.pone.0116191. eCollection 2015.

論文名稱:The adjuvant effects of high-molecule-weight polysaccharides purified from Antrodia cinnamomea on dendritic cell function and DNA vaccines.

作  者:Lin CC, Pan IH, Li YR, Pan YG, Lin MK, Lu YH, Wu HC, Chu CL

出 版 年:2015

分  類:抗發炎

論文結論:The water extract of Antrodia cinnamomea high-molecular weight polysaccharides (AC hmwPSs) promoted pro-inflammatory cytokine production by dendritic cells (DCs) and the maturation of DCs. DC-induced antigen-specific T cell activation and Th1 differentiation were increased by AC hmwPSs.

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論文出處:Bioorg Med Chem Lett. 2015 Oct 15;25(20):4637-41. doi: 10.1016/j.bmcl.2015.08.038. Epub 2015 Aug 20.

論文名稱:Immunosuppressive effect of zhankuic acid C from Taiwanofungus camphoratus on dendritic cell activation and the contact hypersensitivity response.

作  者:Lin MK, Lee MS, Chang WT, Chen HY, Chen JF, Li YR, Lin CC, Wu TS

出 版 年:2015

分  類:抗發炎

論文結論:Zhankuic acid C (ZAC), a ergostane triterpenoids from Taiwanofungus camphoratus, exhibits an immunosuppressive effect on dendritic cells (DC) activation and the contact hypersensitivity response in mice. That ZAC can potentially be used for treating chronic inflammation and autoimmune diseases.

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論文出處:BMC Complement Altern Med. 2015 Jul 16;15:237. doi: 10.1186/s12906-015-0768-3.

論文名稱:Effects of Antrodia camphorata extracts on anti-oxidation, anti-mutagenesis and protection of DNA against hydroxyl radical damage.

作  者:Hsieh YL, Wu SP, Fang LW, Hwang TS

出 版 年:2015

分  類:抗發炎

論文結論:Antrodia camphorata is a non-toxic and novel material with antioxidant, antimutagenic and DNA-protective activities. That reducing and scavenging activities against superoxide anion radical and also exhibited protective effects on DNA against hydroxyl radical-induced damage.

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論文出處:J Ethnopharmacol. 2015 Jan 15;159:113-21. doi: 10.1016/j.jep.2014.11.015. Epub 2014 Nov 18.

論文名稱:Anti-inflammatory effects of Antrodia camphorata, a herbal medicine, in a mouse skin ischemia model.

作  者:Tsai TC, Tung YT, Kuo YH, Liao JW, Tsai HC, Chong KY, Chen HL, Chen CM

出 版 年:2015

分  類:抗發炎

論文結論:Methanolic extracts of wood-cultured fruiting bodies and solid-state-cultured mycelia from Antrodia camphorata and its active compound, ergostatrien-3β-ol (ST1) have anti-inflammatory activities.

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論文出處:Food Hydrocolloids Volume 53, February 2016, Pages 37-45. https://doi.org/10.1016/j.foodhyd.2014.09.035

論文名稱:Studies on anti-inflammatory activity of sulfated polysaccharides from cultivated fungi Antrodia cinnamomea

作  者:Cheng JJ, Chao CH, Chang PC, Lu MK

出 版 年:2016

分  類:抗發炎

論文結論:

Polysaccharides (PSs) and sulfated polysaccharides (SPSs) were isolated from the mycelia of Antrodia cinnamomea. SPSs showed a stronger inhibitory effect on tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) release compared to those of non-sulfated polysaccharide (PS).

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