學術論文


Academic papers

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論文出處:Evid Based Complement Alternat Med. 2011;2011:212641. doi: 10.1093/ecam/nep108. Epub 2011 Jan 3.

論文名稱:Review of Pharmacological Effects of Antrodia camphorata and Its Bioactive Compounds

作  者:Geethangili M, Tzeng YM

出 版 年:2011

分  類:抗癌

論文結論:Antrodia camphorata can be considered as an efficient alternative phytotherapeutic agent or a synergizer in the treatment of cancer and other immune-related diseases. And the next step is to produce some medicines from Antrodia camphorata, however, the production may be hampered by problems related to mass production.

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論文出處:J Agric Food Chem. 2011 Aug 24;59(16):8625-31. doi: 10.1021/jf2011326. Epub 2011 Jul 26.

論文名稱:4-acetylantroquinonol B isolated from Antrodia cinnamomea arrests proliferation of human hepatocellular carcinoma HepG2 cell by affecting p53, p21 and p27 levels.

作  者:Lin YW, Chiang BH.

出 版 年:2011

分  類:抗癌

論文結論:4-acetylantroquinonol B, isolated from the mycelium of Antrodia cinnamomea, inhibits proliferation of HepG2 cells via affecting p53, p21 and p27 proteins, CDK2 and CDK4 proteins downregulations. The proportion of cells in the G1 phase of the cell cycle increased and that in the S phase decreased significantly, and the proportion of G2/M phase cells were not obviously changed.

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論文出處:J Ethnopharmacol. 2011 Jun 14;136(1):168-77. doi: 10.1016/j.jep.2011.04.030. Epub 2011 Apr 20.

論文名稱:Antroquinonol from ethanolic extract of mycelium of Antrodia cinnamomea protects hepatic cells from ethanol-induced oxidative stress through Nrf-2 activation.

作  者:Kumar KJ, Chu FH, Hsieh HW, Liao JW, Li WH, Lin JC, Shaw JF, Wang SY

出 版 年:2011

分  類:抗癌

論文結論:Ethanolic extracts of mycelia of Antrodia cinnamomea (EMAC) and Antroquinonol, a potent bioactive compound from Antrodia cinnamomea, may be responsible for the hepatoprotective activity.

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論文出處:J Agric Food Chem. 2011 Oct 26;59(20):10943-54. doi: 10.1021/jf202771d. Epub 2011 Oct 5.

論文名稱:Antcin B and its ester derivative from Antrodia camphorata induce apoptosis in hepatocellular carcinoma cells involves enhancing oxidative stress coincident with activation of intrinsic and extrinsic apoptotic pathway.

作  者:Hsieh YC, Rao YK, Whang-Peng J, Huang CY, Shyue SK, Hsu SL, Tzeng YM.

出 版 年:2011

分  類:抗癌

論文結論:The triterpenoids, methylantcinate B (MAB) and antcin B (AB), isolated from Antrodia camphorata, induced apoptosis in HepG2 cells, as characterized by increased DNA fragmentation, cleavage of PARP, sub-G1 population, chromatin condensation, loss of mitochondrial membrane potential, and release of cytochrome c.

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論文出處:Evid Based Complement Alternat Med. 2011;2011:914561. doi: 10.1093/ecam/nep228. Epub 2011 Mar 13.

論文名稱:A Preclinical Evaluation of Antrodia camphorata Alcohol Extracts in the Treatment of Non-Small Cell Lung Cancer Using Non-Invasive Molecular Imaging.

作  者:Chiou JF, Wu AT, Wang WT, Kuo TH, Gelovani JG, Lin IH, Wu CH, Chiu WT, Deng WP.

出 版 年:2011

分  類:抗癌

論文結論:Antrodia camphorata alcohol extract (ACAE) contains anti-cancer properties and could be considered as a potential CAM agent in future clinical evaluation.

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論文出處:Mutat Res. 2011 Feb 10;707(1-2):42-52. doi: 10.1016/j.mrfmmm.2010.12.009. Epub 2010 Dec 24.

論文名稱:Antroquinonol inhibits NSCLC proliferation by altering PI3K/mTOR proteins and miRNA expression profiles.

作  者:Kumar VB, Yuan TC, Liou JW, Yang CJ, Sung PJ, Weng CF.

出 版 年:2011

分  類:抗癌

論文結論:Antroquinonol treatment significantly reduced the proliferation of NSCLC cells, increased cell shrinkage, apoptotic vacuoles, pore formation, and increased Sub-G1 cell population.

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論文出處:Evid Based Complement Alternat Med. 2011;2011:750230. doi: 10.1155/2011/750230. Epub 2011 Mar 9.

論文名稱:Apoptotic Cell Death and Inhibition of Wnt/β-Catenin Signaling Pathway in Human Colon Cancer Cells by an Active Fraction (HS7) from Taiwanofungus camphoratus.

作  者:Yeh CT, Yao CJ, Yan JL, Chuang SE, Lee LM, Chen CM, Yeh CF, Li CH, Lai GM.

出 版 年:2011

分  類:抗癌

論文結論:HS7, an active fraction extracted from Taiwanofungus camphoratus, significantly inhibited proliferation of HT29, HCT116, and SW480 colon cancer cells.

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論文出處:Evid Based Complement Alternat Med. 2011;2011:984027. doi: 10.1093/ecam/nep020. Epub 2011 Jun 8.

論文名稱:Inhibition of Anchorage-Independent Proliferation and G0/G1 Cell-Cycle Regulation in Human Colorectal Carcinoma Cells by 4,7-Dimethoxy-5-Methyl-l,3-Benzodioxole Isolated from the Fruiting Body of Antrodia camphorate.

作  者:Lien HM, Lin HW, Wang YJ, Chen LC, Yang DY, Lai YY, Ho YS

出 版 年:2011

分  類:抗癌

論文結論:4,7-dimethoxy-5-methyl-l,3-benzodioxole (SY-1) was isolated from three different sources of dried fruiting bodies of Antrodia camphorate (AC). That inhibits human colon cancer cell (COLO 205) proliferation through inhibition of cell growth and anchorage-independent colony formation in soft agar.

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論文出處:J Agric Food Chem. 2011 Oct 26;59(20):11255-63. doi: 10.1021/jf2024215. Epub 2011 Sep 25.

論文名稱:Pretreatment with an ethanolic extract of Taiwanofungus camphoratus (Antrodia camphorata) enhances the cytotoxic effects of amphotericin B.

作  者:Chen LY, Sheu MT, Liu DZ, Liao CK, Ho HO, Kao WY, Ho YS, Lee WS, Su CH.

出 版 年:2011

分  類:抗癌

論文結論:Combined treatment with amphotericin B (AmB) and ethanolic extract of Taiwanofungus camphoratus (TCEE) effectively induced apoptosis and inhibited tumor growth.

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論文出處:Evid Based Complement Alternat Med. 2011;2011:450529. doi: 10.1093/ecam/nep230. Epub 2011 May 3.

論文名稱:Study of the Anti-Proliferative Activity of 5-Substituted 4,7-Dimethoxy-1,3-Benzodioxole Derivatives of SY-1 from Antrodia camphorata on Human COLO 205 Colon Cancer Cells.

作  者:Lien HM, Kuo PT, Huang CL, Kao JY, Lin H, Yang DY, Lai YY.

出 版 年:2011

分  類:抗癌

論文結論:SY-1 (4,7-dimethoxy-5-methyl-l,3-benzodioxole) was isolated from Antrodia camphorata, and the analogue “apiole”(5-Substituted 4,7-Dimethoxy-1,3-Benzodioxole) decreased the proliferation of human colorectal carcinoma cancer cells (COLO 205).

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論文出處:Chem Res Toxicol. 2011 Feb 18;24(2):238-45. doi: 10.1021/tx100318m. Epub 2010 Dec 15.

論文名稱:Identification of antrocin from Antrodia camphorata as a selective and novel class of small molecule inhibitor of Akt/mTOR signaling in metastatic breast cancer MDA-MB-231 cells.

作  者:Rao YK, Wu AT, Geethangili M, Huang MT, Chao WJ, Wu CH, Deng WP, Yeh CT, Tzeng YM

出 版 年:2011

分  類:抗癌

論文結論:Antrocin, isolated from Antrodia camphorata, as an Akt/mTOR dual inhibitor  for the treatment of metastatic breast cancer MDA-MB-231 cells (MMCs).

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論文出處:Food Chem Toxicol. 2011 Jan;49(1):290-8. doi: 10.1016/j.fct.2010.10.031. Epub 2010 Nov 4.

論文名稱:Anti-metastatic activities of Antrodia camphorata against human breast cancer cells mediated through suppression of the MAPK signaling pathway.

作  者:Yang HL, Kuo YH, Tsai CT, Huang YT, Chen SC, Chang HW, Lin E, Lin WH, Hseu YC.

出 版 年:2011

分  類:抗癌

論文結論:Antrodia camphorata markedly inhibited the invasion/migration of highly metastatic MDA-MB-231 cells as shown by an in vitro transwell and a wound-healing repair assay.

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論文出處:Int J Gynecol Cancer. 2011 Oct;21(7):1172-9. doi: 10.1097/IGC.0b013e31821f742c.

論文名稱:Antrodia camphorata induces apoptosis and enhances the cytotoxic effect of paclitaxel in human ovarian cancer cells.

作  者:Liu FS, Yang PY, Hu DN, Huang YW, Chen MJ.

出 版 年:2011

分  類:抗癌

論文結論:Crude extract of Antrodia camphorata causes a cytotoxic effect on ovarian cancer cells through the induction of apoptosis. It may also enhance the antitumor effect of paclitaxel.

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論文出處:J Nat Prod. 2012 Nov 26;75(11):2016-44. doi: 10.1021/np300412h. Epub 2012 Oct 23.

論文名稱:Lanostanoids from fungi: a group of potential anticancer compounds.

作  者:Ríos JL, Andújar I, Recio MC, Giner RM.

出 版 年:2012

分  類:抗癌

論文結論:This review showed that lanostanes are a group of tetracyclic triterpenoids derived from lanosterol. They have great potential as anticancer agents because of their cytotoxic or apoptotic effects. To arrest the cell cycle in the G1 phase, increase levels of p53 and Bax, or inhibit the phosphorylation of Erk1/2 or the activation of NF-κB and AP-1. Have inhibitory effects on the growth of androgen prostate carcinoma through increasing the expression of p21, which activates the tumor suppressor protein p53.

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論文出處:Phytochemistry. 2012 Dec;84:177-83. doi: 10.1016/j.phytochem.2012.08.011. Epub 2012 Sep 18.

論文名稱:Lanostane triterpenoids and sterols from Antrodia camphorata.

作  者:Huang HC, Liaw CC, Yang HL, Hseu YC, Kuo HT, Tsai YC, Chien SC, Amagaya S, Chen YC, Kuo YH.

出 版 年:2012

分  類:抗癌

論文結論:Four lanostane triterpenes (3,7,11-trioxo-5α-lanosta-8,24(E)-dien-26-oic acid, methyl 11α-3,7-dioxo-5α-lanosta-8,24(E)-dien-26-oate, methyl 3,7,11,12,15,23-hexaoxo-5α-lanost-8-en-26-oate, and ethyl 3,7,11,12,15,23-hexaoxo-5α-lanost-8-en-26-oate) and two sterols (camphosterol A and (14α,22E)-14-hydroxyergosta-7,22-diene-3,6-dione) were isolated from a mixture of fruiting bodies and mycelia of Antrodia camphorata. Six compounds were have activity for cytotoxicity against human tumor cell lines.

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