學術論文


Academic papers

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論文出處:J Agric Food Chem. 2014 Jun 18;62(24):5625-35. doi: 10.1021/jf4056924. Epub 2014 Jun 6.

論文名稱:Antroquinonol D, isolated from Antrodia camphorata, with DNA demethylation and anticancer potential.

作  者:Wang SC, Lee TH, Hsu CH, Chang YJ, Chang MS, Wang YC, Ho YS, Wen WC, Lin RK.

出 版 年:2014

分  類:抗癌

論文結論:Antroquinonol D (3-demethoxyl antroquinonol), a new DNA methyltransferase 1 (DNMT1) inhibitor, was isolated from Antrodia camphorata. Inhibited the growth of breast cancer cells (MCF7, T47D, and MDA-MB-231) and the migratory potential.

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論文出處:Food Funct. 2014 Dec;5(12):3224-32. doi: 10.1039/c4fo00720d.

論文名稱:Anticancer effects on human pancreatic cancer cells of triterpenoids, polysaccharides and 1,3-β-D-glucan derived from the fruiting body of Antrodia camphorata.

作  者:Lee CI, Wu CC, Hsieh SL, Lee CL, Chang YP, Chang CC, Wang YZ, Wang JJ.

出 版 年:2014

分  類:抗癌

論文結論:Analyzed triterpenoids, polysaccharides and 1,3-β-D-glucan, three major effective components in Antrodia camphorata extracts (ACE). And shows great therapeutic potential due to its cytotoxic effects against BxPC-3 cells which include inhibiting cell migration and inducing mitochondria-mediated apoptosis.

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論文出處:Oncotarget. 2015 Sep 22;6(28):25741-54. doi: 10.18632/oncotarget.4348.

論文名稱:Antrodia cinnamomea alleviates cisplatin-induced hepatotoxicity and enhances chemo-sensitivity of line-1 lung carcinoma xenografted in BALB/cByJ mice.

作  者:Huang TH, Chiu YH, Chan YL, Wang H, Li TL, Liu CY, Yang CT, Lee TY, You JS, Hsu KH, Wu CJ

出 版 年:2015

分  類:抗癌

論文結論:Antrodia cinnamomea inhibited proliferation of line-1 lung carcinoma cells and rescued hepatic HepG2 cells from cisplatin-induced cell death in vitro.

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論文出處:J Pharm Biomed Anal. 2015;111:266-76. doi: 10.1016/j.jpba.2015.04.010. Epub 2015 Apr 10.

論文名稱:Metabolites identification and multi-component pharmacokinetics of ergostane and lanostane triterpenoids in the anticancer mushroom Antrodia cinnamomea.

作  者:Qiao X, Wang Q, Ji S, Huang Y, Liu KD, Zhang ZX, Bo T, Tzeng YM, Guo DA, Ye M

出 版 年:2015

分  類:抗癌

論文結論:The low-polarity ergostanes (antcins B and C) undertook hydrogenation (C-3 or C-7 carbonyl groups) or hydroxylation to produce polar metabolites. High-polarity ergostanes (antcins H and K) and Δ(7,9(11)) lanostanes were metabolically stable. The ergostanes were generally absorbed and eliminated rapidly, whereas the lanostanes remained in the plasma at a low concentration for a relatively long time. High-polarity ergostanes are the major plasma-exposed components of Antrodia cinnamomea, and may play an important role in its therapeutic effects.

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論文出處:Int J Med Mushrooms. 2015;17(6):533-40.

論文名稱:Antitumor Compounds from the Stout Camphor Mushroom Taiwanofungus camphoratus (Higher Basidiomycetes) Spent Culture Broth.

作  者:Jia W, Bai YY, Zhang Z, Feng N, Feng J, Yan MQ, Zhu LN, Jia XC, Wang MD, Zhang JS, Fan H

出 版 年:2015

分  類:抗癌

論文結論:A known compound, 5-(hydroxymethyl) furan-2-carbaldehyde, and a novel compound, 3-isobutyl-1-methoxy-4-(4'-(3-methylbut-2-enyloxy)phenyl)-1H-pyrrole-2,5-dione were isolated from submerged cultures of Taiwanofungus camphoratus. These compounds inhibited the proliferation of K562 and HepG2 tumor cells in vitro.

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論文出處:Fitoterapia. 2015 Apr;102:115-9. doi: 10.1016/j.fitote.2015.02.010. Epub 2015 Feb 23.

論文名稱:Anti-cancer agents derived from solid-state fermented Antrodia camphorata mycelium.

作  者:Yen IC, Yao CW, Kuo MT, Chao CL, Pai CY, Chang WL

出 版 年:2015

分  類:抗癌

論文結論:Three new ubiquinone derivatives, antrocamol LT1, antrocamol LT2, and antrocamol LT3, along with two known compounds, were isolated from Antrodia camphorata. Have cytotoxicities against five human cancer cell lines (CT26, A549, HepG2, PC3 and DU-145).

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論文出處:J Tradit Complement Med. 2015 Feb 4;6(1):48-56. doi: 10.1016/j.jtcme.2014.11.026. eCollection 2016 Jan.

論文名稱:Antcin K, an active triterpenoid from the fruiting bodies of basswood cultivated Antrodia cinnamomea, induces mitochondria and endoplasmic reticulum stress-mediated apoptosis in human hepatoma cells.

作  者:Lai CI, Chu YL, Ho CT, Su YC, Kuo YH, Sheen LY

出 版 年:2015

分  類:抗癌

論文結論:Antcin K induced mitochondrial and endoplasmic reticulum stress-mediated apoptosis in human hepatoma cells. The principal mode of Hep 3B cells death induced by antcin K was apoptosis, rather than autophagy or necrosis.

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論文出處:Am J Chin Med. 2015;43(8):1671-96. doi: 10.1142/S0192415X15500950. Epub 2015 Nov 30.

論文名稱:Antrodia cinnamomea Inhibits Migration in Human Hepatocellular Carcinoma Cells: The Role of ERp57 and PGK-1.

作  者:Chen YY, Liu FC, Wu TS, Sheu MJ

出 版 年:2015

分  類:抗癌

論文結論:Ethanol extract of fruiting bodies of Antrodia cinnamomea (EEAC) and its active ingredients (i.e., zhankuic acid A, cordycepin, and adenosine) can modulate HCC cancer cells migration through down-regulation of ERp57, PGK-1, MAPK, and PI3K/Akt.

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論文出處:J Agric Food Chem. 2015 May 13;63(18):4561-9. doi: 10.1021/jf5059304. Epub 2015 May 5.

論文名稱:Antcin K, an Active Triterpenoid from the Fruiting Bodies of Basswood-Cultivated Antrodia cinnamomea, Inhibits Metastasis via Suppression of Integrin-Mediated Adhesion, Migration, and Invasion in Human Hepatoma Cells.

作  者:Huang YL, Chu YL, Ho CT, Chung JG, Lai CI, Su YC, Kuo YH, Sheen LY

出 版 年:2015

分  類:抗癌

論文結論:Antcin K, ergostane-type triterpenoids of Antrodia cinnamomea, was able to inhibit the metastasis of human hepatoma cells through suppression of integrin-mediated adhesion, migration, and invasion.

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論文出處:J Agric Food Chem. 2015 Jan 14;63(1):208-15.

論文名稱:4-Acetylantroquinonol B suppresses tumor growth and metastasis of hepatoma cells via blockade of translation-dependent signaling pathway and VEGF production.

作  者:Chang CH, Huang TF, Lin KT, Hsu CC, Chang WL, Wang SW, Ko FN, Peng HC, Chung CH.

出 版 年:2015

分  類:抗癌

論文結論:4-acetylantroquinonol B (4AAQB), isolated from Antrodia cinnamomea, was observed to inhibit HepG2 and HuH-7 hepatoma cell growth in both in vitro and in vivo models via affecting cell cycle and exhibited pronounced inhibitory effects on HuH-7 tumor growth in xenograft and orthotopic models.

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論文出處:Biomed Res Int. 2015;2015:415269. doi: 10.1155/2015/415269. Epub 2015 Oct 18.

論文名稱:The Ethanolic Extract of Taiwanofungus camphoratus (Antrodia camphorata) Induces Cell Cycle Arrest and Enhances Cytotoxicity of Cisplatin and Doxorubicin on Human Hepatocellular Carcinoma Cells.

作  者:Lin LT, Tai CJ, Su CH, Chang FM, Choong CY, Wang CK, Tai CJ

出 版 年:2015

分  類:抗癌

論文結論:Ethanolic extract of Antrodia camphorata (TCEE) treatment induced cell cycle arrest and suppressed cell growth on both Hep3B and HepJ5 cells. Expression of cell cycle inhibitors, P21 and P27, and activation of apoptosis executer enzyme, caspase-3, were also induced by TCEE.

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論文出處:PLoS One. 2015 Sep 1;10(9):e0136782. doi: 10.1371/journal.pone.0136782. eCollection 2015.

論文名稱:Apoptosis of Hepatocellular Carcinoma Cells Induced by Nanoencapsulated Polysaccharides Extracted from Antrodia Camphorata.

作  者:Chang JS, Kuo HP, Chang KL, Kong ZL

出 版 年:2015

分  類:抗癌

論文結論:ACE polysaccharides, ACE/CS and ACE/S all could damage the Hep G2 cell membrane and cause cell death, especially in the ACE/CS group. The encapsulation of ACE polysaccharides by chitosan-silica nanoparticles may provide a viable approach for enhancing anti-tumor efficacy in liver cancer cells.

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論文出處:J Nat Med. 2015 Oct;69(4):513-21. doi: 10.1007/s11418-015-0916-6. Epub 2015 May 8.

論文名稱:2,3,5-Trimethoxy-4-cresol, an anti-metastatic constituent from the solid-state cultured mycelium of Antrodia cinnamomea and its mechanism.

作  者:Lin CC, Chen CC, Kuo YH, Kuo JT, Senthil Kumar KJ, Wang SY.

出 版 年:2015

分  類:抗癌

論文結論:An anti-metastatic compound, 2,3,5-trimethoxy-4-cresol (TMC), was isolated from the solid-state cultured mycelium of Antrodia cinnamomea. TMC effectively suppressed movement, migration and invasion of lung cancer cells. Reduced protein expression of Akt, MMP-2 and MMP-9 and enhanced E-cadherin and TIMP-1 protein expression.

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論文出處:Int J Biol Macromol. 2015 Mar;74:476-82. doi: 10.1016/j.ijbiomac.2015.01.004. Epub 2015 Jan 10.

論文名稱:Anti-metastatic effects of antrodan, the Antrodia cinnamomea mycelia glycoprotein, in lung carcinoma cells.

作  者:Fa KN, Yang CM, Chen PC, Lee YY, Chyau CC, Hu ML

出 版 年:2015

分  類:抗癌

論文結論:Antrodan was isolated from Antrodia cinnamomea mycelia, significantly inhibit invasion and migration of Lewis lung carcinoma (LLC) cells.

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論文出處:Mol Clin Oncol. 2015 Nov;3(6):1375-1380. Epub 2015 Sep 15.

論文名稱:A phase I multicenter study of antroquinonol in patients with metastatic non-small-cell lung cancer who have received at least two prior systemic treatment regimens, including one platinum-based chemotherapy regimen.

作  者:Lee YC, Ho CL, Kao WY, Chen YM

出 版 年:2015

分  類:抗癌

論文結論:This first in-human phase I study of antroquinonol included patients with metastatic non-small-cell lung cancer. An open-label, dose escalation, pharmacokinetic (PK) study was conducted to determine the maximum tolerable dose (MTD), dose-limiting toxicities (DLTs), and safety/tolerability and preliminary efficacy profiles of antroquinonol. Treatment with antroquinonol was generally safe and well tolerated, without DLTs. And the recommended dose level for a phase II study is ≥600 mg daily.

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