學術論文


Academic papers

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論文出處:Carbohydr Polym. 2017 Jul 1;167:229-239. doi: 10.1016/j.carbpol.2017.02.104. Epub 2017 Mar 6.

論文名稱:Characterization of a sulfated galactoglucan from Antrodia cinnamomea and its anticancer mechanism via TGFβ/FAK/Slug axis suppression.

作  者:Lu MK, Lin TY, Hu CH, Chao CH, Chang CC, Hsu HY

出 版 年:2017

分  類:抗癌

論文結論:A sulfated polysaccharides 1,4-β-d-galactoglucan (B86-III) with 1,6-branches was isolated and identified from Antrodia cinnamomea. B86-III inhibited the viability of H1975 lung cancer cells via cell apoptosis, including the activation of caspase 3 and PARP. Also downregulated TGFR I protein levels and inhibited FAK phosphorylation, resulting in inhibition of Slug expression and migration.

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論文出處:Int J Biol Macromol. 2017 Feb;95:1144-1152. doi: 10.1016/j.ijbiomac.2016.11.004. Epub 2016 Nov 4.

論文名稱:Molecular mechanism of Antrodia cinnamomea sulfated polysaccharide on the suppression of lung cancer cell growth and migration via induction of transforming growth factor β receptor degradation.

作  者:Lu MK, Lin TY, Chao CH, Hu CH, Hsu HY

出 版 年:2017

分  類:抗癌

論文結論:A sulfated polysaccharide of Antrodia cinnamomea (SPS) has been identified as a novel immunomodulatory agent. SPS inhibits the growth of A549 and LLC1 lung cancer cells via the induction of cell cycle arrest and activation of caspase 3 and PARP.SPS suppresses TGFβ-induced intracellular signaling events, including phosphorylation of Smad2/3, FAK, Akt, and cell migration.

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論文出處:Int J Med Mushrooms. 2017;19(3):225-232. doi: 10.1615/IntJMedMushrooms.v19.i3.40.

論文名稱:Antitumor Effect of By-1 from Spent Broth from Submerged Cultures of Stout Camphor Medicinal Mushroom, Taiwanofungus camphoratus (Higher Basidiomycetes), on A549 Adenocarcinoma Cells.

作  者:Wang WH, Wang LY, Yang HR, Zhang YP, Zhang HN, Fan H, Zhao XL, Zhang JS, Jia W

出 版 年:2017

分  類:抗癌

論文結論:By-1 was obtained from submerged cultures of Taiwanofungus camphoratus. By-1 could dramatically inhibit the viability of A549 cells in vitro. Proliferation rates of A549 cells were significantly inhibited. Increased the number of cells in the G0/G1 phases of the cell cycle. And induce A549 cells apoptosis, and this apoptosis was related to the release of reactive oxygen species (ROS).

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論文出處:Chin Med. 2017 Nov 15;12:33. doi: 10.1186/s13020-017-0154-9. eCollection 2017.

論文名稱:Active fraction (HS7) from Taiwanofungus camphoratus inhibits AKT-mTOR, ERK and STAT3 pathways and induces CDK inhibitors in CL1-0 human lung cancer cells.

作  者:Lai IC, Lai GM, Chow JM, Lee HL, Yeh CF, Li CH, Yan JL, Chuang SE, Whang-Peng J, Bai KJ, Yao CJ

出 版 年:2017

分  類:抗癌

論文結論:The active fraction HS7 from n-hexane extract of Taiwanofungus camphoratus exerts multi-targeting activity on the suppression of AKT-mTOR, ERK and STAT3 pathways and induction of p15, p21 and p27 in EGFR wild-type NSCLC cells. This  is suggests its potential as an alternative medicine for the treatment of EGFR TKIs resistant NSCLC.

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論文出處:J Agric Food Chem. 2017 Jan 11;65(1):51-59. doi: 10.1021/acs.jafc.6b04101. Epub 2016 Dec 20.

論文名稱:Antroquinonol, a Ubiquinone Derivative from the Mushroom Antrodia camphorata, Inhibits Colon Cancer Stem Cell-like Properties: Insights into the Molecular Mechanism and Inhibitory Targets.

作  者:Lin HC, Lin MH, Liao JH, Wu TH, Lee TH, Mi FL, Wu CH, Chen KC, Cheng CH, Lin CW

出 版 年:2017

分  類:抗癌

論文結論:Antroquinonol (ANQ) is a ubiquinone derivative from Antrodia camphorata, which exhibits inhibitory activities toward migration/invasion and tumorsphere formation of colon cancer cells. And the first time suppresses stem cell-like properties via targeting PI3K/AKT/β-catenin signaling.

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論文出處:J Ethnopharmacol. 2017 Jul 5;208:72-83. doi: 10.1016/j.jep.2017.07.001. [Epub ahead of print]

論文名稱:Antrodia camphorata inhibits metastasis and epithelial-to-mesenchymal transition via the modulation of claudin-1 and Wnt/β-catenin signaling pathways in human colon cancer cells.

作  者:Hseu YC, Chao YH, Lin KY, Way TD, Lin HY, Thiyagarajan V, Yang HL

出 版 年:2017

分  類:抗癌

論文結論:The anti-metastatic and anti-EMT activities of Antrodia camphorata, which may contribute to the development of a chemopreventive agent for colon cancer.

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論文出處:Mol Med Rep. 2017 Aug 10. doi: 10.3892/mmr.2017.7207. [Epub ahead of print]

論文名稱:Ethanol extract of Antrodia camphorata inhibits proliferation of HCT-8 human colorectal cancer cells by arresting cell cycle progression and inducing apoptosis.

作  者:Wang G, Wan Y, Zhao J, Hong Z

出 版 年:2017

分  類:抗癌

論文結論:Antrodia camphorata (AC) exhibited antiproliferative and growth inhibition effects on HCT‑8 cells via induction of apoptosis and blocking of cell cycle progression, thus suggesting that it may have anticancer properties valuable for potential future therapeutic application for the treatment of colorectal cancer (CRC).

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論文出處:Phytomedicine. 2017 Jan 15;24:39-48. doi: 10.1016/j.phymed.2016.11.006. Epub 2016 Nov 8.

論文名稱:Novel effect and the mechanistic insights of fruiting body extract of medicinal fungus Antrodia cinnamomea against T47D breast cancer.

作  者:Shang KM, Su TH, Lee WL, Hsiao WW, Chiou CY, Ho BY, Wang SY, Shyur LF

出 版 年:2017

分  類:抗癌

論文結論:AC-3E extracts can be employed as a double-barreled approach to treat human ER+ breast cancer by attacking both cancer cells and tumor-associated blood vessel cells.

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論文出處:Evid Based Complement Alternat Med. 2017;2017:5052870. doi: 10.1155/2017/5052870. Epub 2017 Nov 2.

論文名稱:Antcin-H Isolated from Antrodia cinnamomea Inhibits Renal Cancer Cell Invasion Partly through Inactivation of FAK-ERK-C/EBP-β/c-Fos-MMP-7 Pathways.

作  者:Chiu KY, Chen TH, Wen CL, Lai JM, Cheng CC, Liu HC, Hsu SL, Tzeng YM

出 版 年:2017

分  類:抗癌

論文結論:Antcin-H, a natural triterpene from Antrodia cinnamomea, inhibited the growth of human renal carcinoma 786-0 cells. That may be an active component existing in Antrodia cinnamomea with anticancer effect.

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論文出處:J Ethnopharmacol. 2017 Apr 6;201:117-122. doi: 10.1016/j.jep.2017.02.008. Epub 2017 Feb 4.

論文名稱:Pinicolol B from Antrodia cinnamomea induces apoptosis of nasopharyngeal carcinoma cells.

作  者:Wu TR, Huang TT, Martel J, Liau JC, Chiu CY, Leu YL, Jian WT, Chang IT, Lu CC, Ojcius DM, Ko YF, Lai HC, Young JD

出 版 年:2017

分  類:抗癌

論文結論:lanosta-7,9(11),24-trien-3β,15α,21-triol (Pinicolol B), a lanostanoid compound isolated from Antrodia cinnamomea mycelium and may contribute to the anticancer effects in nasopharyngeal cancer cells (TW02 and TW04).

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論文出處:J Ethnopharmacol. 2018 Mar 30. pii: S0378-8741(18)30546-4. doi: 10.1016/j.jep.2018.03.041. [Epub ahead of print]

論文名稱:Antrodia cinnamomea produces anti-angiogenic effects by inhibiting the VEGFR2 signaling pathway.

作  者:Huang TT, Lan YW, Ko YF, Chen CM, Lai HC, Ojcius DM, Martel J, Young JD, Chong KY

出 版 年:2018

分  類:抗癌

論文結論:Antrodia cinnamomea ethanol extract (ACEE) produces anti-angiogenic effects by inhibiting the VEGFR2 signaling pathway.

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論文出處:Int J Mol Sci. 2018 Mar 9;19(3). pii: E791. doi: 10.3390/ijms19030791.

論文名稱:Suppression of Cell Growth, Migration and Drug Resistance by Ethanolic Extract of Antrodia cinnamomea in Human Lung Cancer A549 Cells and C57BL/6J Allograft Tumor Model.

作  者:Wu CH, Liu FC, Pan CH, Lai MT, Lan SJ, Wu CH, Sheu MJ

出 版 年:2018

分  類:抗癌

論文結論:Ethanolic extracts from Antrodia cinnamomea (EEAC) induced cell cycle arrest at the G0/G1 phase resulting decreased cell viability in A549 cells.  Also inhibited A549 cell migration and reduced expression of gelatinases.

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論文出處:Int J Mol Sci. 2018 May 24;19(6). pii: E1565. doi: 10.3390/ijms19061565.

論文名稱:Anti-Metastatic Effects of Antrodan with and without Cisplatin on Lewis Lung Carcinomas in a Mouse Xenograft Model.

作  者:Chen PC, Chen CC, Ker YB, Chang CH, Chyau CC, Hu ML

出 版 年:2018

分  類:抗癌

論文結論:Antrodan, derived from the fungal mycelia of Antrodia cinnamomea, provides a novel, complementary therapeutic strategy against cancer metastasis, by attenuating the activities of MMP-2 and -9 through the modulation of STAT3/MAPK/ERK/JNK signaling pathways.

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論文出處:BMC Complement Altern Med. 2018 May 9;18(1):152. doi: 10.1186/s12906-018-2204-y.

論文名稱:Antrodia cinnamomea extract inhibits the proliferation of tamoxifen-resistant breast cancer cells through apoptosis and skp2/microRNAs pathway.

作  者:Lin YS, Lin YY, Yang YH, Lin CL, Kuan FC, Lu CN, Chang GH, Tsai MS, Hsu CM, Yeh RA, Yang PR, Lee IY, Shu LH, Cheng YC, Liu HT, Lee KD, Chang DC, Wu CY

出 版 年:2018

分  類:抗癌

論文結論:The ethanol extract of antrodia cinnamomea can inhibit the growth of breast cancer cells and induce apoptosis in these breast cancer cells, including MCF-7 cell and tamoxifen-resistant MCF-7 cell lines. It could be a novel anticancer agent in the armamentarium of tamoxifen-resistant breast cancer management.

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論文出處:Food Chem Toxicol. 2018 Feb 21. pii: S0278-6915(18)30028-0. doi: 10.1016/j.fct.2018.01.028. [Epub ahead of print]

論文名稱:Antrodia cinnamomea mycelial fermentation broth inhibits the epithelial-mesenchymal transition of human esophageal adenocarcinoma cancer cells.

作  者:Liu YM, Liu YK, Huang PI, Tsai TH, Chen YJ

出 版 年:2018

分  類:抗癌

論文結論:Antrodia cinnamomea mycelial fermentation broth (AC-MFB) was not only able to upregulate the expression of Ecadherin and attenuate the TGF-β-induced overexpression of vimentin and N-cadherin, but it also reversed the TGF-β-induced changes in cell morphology from polygonal to spindle-shaped and delayed the migration potential of human esophageal cancer cells (BE3). And AC-MFB was able to inhibit the epithelial mesenchymal transition (EMT) of esophageal cancer BE3 cells, which was accompanied by Twist and Twist1 downregulation.

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