學術論文


Academic papers

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論文出處:BMC Complement Altern Med. 2018 May 9;18(1):152. doi: 10.1186/s12906-018-2204-y.

論文名稱:Antrodia cinnamomea extract inhibits the proliferation of tamoxifen-resistant breast cancer cells through apoptosis and skp2/microRNAs pathway.

作  者:Lin YS, Lin YY, Yang YH, Lin CL, Kuan FC, Lu CN, Chang GH, Tsai MS, Hsu CM, Yeh RA, Yang PR, Lee IY, Shu LH, Cheng YC, Liu HT, Lee KD, Chang DC, Wu CY

出 版 年:2018

分  類:抗癌

論文結論:The ethanol extract of antrodia cinnamomea can inhibit the growth of breast cancer cells and induce apoptosis in these breast cancer cells, including MCF-7 cell and tamoxifen-resistant MCF-7 cell lines. It could be a novel anticancer agent in the armamentarium of tamoxifen-resistant breast cancer management.

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論文出處:Food Chem Toxicol. 2018 Feb 21. pii: S0278-6915(18)30028-0. doi: 10.1016/j.fct.2018.01.028. [Epub ahead of print]

論文名稱:Antrodia cinnamomea mycelial fermentation broth inhibits the epithelial-mesenchymal transition of human esophageal adenocarcinoma cancer cells.

作  者:Liu YM, Liu YK, Huang PI, Tsai TH, Chen YJ

出 版 年:2018

分  類:抗癌

論文結論:Antrodia cinnamomea mycelial fermentation broth (AC-MFB) was not only able to upregulate the expression of Ecadherin and attenuate the TGF-β-induced overexpression of vimentin and N-cadherin, but it also reversed the TGF-β-induced changes in cell morphology from polygonal to spindle-shaped and delayed the migration potential of human esophageal cancer cells (BE3). And AC-MFB was able to inhibit the epithelial mesenchymal transition (EMT) of esophageal cancer BE3 cells, which was accompanied by Twist and Twist1 downregulation.

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論文出處:Int J Mol Sci. 2018 Oct 10;19(10). pii: E3096. doi: 10.3390/ijms19103096.

論文名稱:Hypermethylation of CCND2 in Lung and Breast Cancer Is a Potential Biomarker and Drug Target.

作  者:Hung CS, Wang SC, Yen YT, Lee TH, Wen WC, Lin RK.

出 版 年:2018

分  類:抗癌

論文結論:

CCND2 is a common target in lung and breast cancer. As compared with paired normal tissues and healthy individuals, CCND2 promoter hypermethylation was detected in 40.9% of breast tumors and 44.4% of plasma circulating cell-free DNA of patients. Hypermethylation of CCND2 is a potential diagnostic, prognostic marker and drug target, and it is induced by antroquinonol D.
1. CCND2 expression inhibited cancer cell growth and migration ability. 
2. Antroquinonol D upregulated CCND2 expression, caused cell cycle arrest, and inhibited cancer cell growth and migration ability. 

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論文出處:Int J Biol Macromol. 2018 Dec;120(Pt B):1551-1560. doi: 10.1016/j.ijbiomac.2018.09.162. Epub 2018 Sep 26.

論文名稱:A polysaccharide from Antrodia cinnamomea mycelia exerts antitumor activity through blocking of TOP1/TDP1-mediated DNA repair pathway.

作  者:Zhang Y, Wang Z, Li D, Zang W, Zhu H, Wu P, Mei Y, Liang Y.

出 版 年:2018

分  類:抗癌

論文結論:A polysaccharide (termed ACPS-1) from mycelia of Antrodia cinnamomea under submerged culture was purified by hot water extraction and successive DEAE-52 cellulose and Sephadex G-100 column chromatography. ACPS-1 induced cancer cell lines (HeLa, A431, H22 and S180) apoptosis and cell cycle arrest (cells remained in G2/M phase) through blocking of topoisomerase I/tyrosyl-DNA phosphodiesterase I (TOP1/TDP1)-mediated DNA repair pathway.

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論文出處:Leuk Lymphoma. 2018 Oct 2:1-11. doi: 10.1080/10428194.2018.1512709. [Epub ahead of print]

論文名稱:The JAK inhibitor antcin H exhibits direct anticancer activity while enhancing chemotherapy against LMP1-expressed lymphoma.

作  者:Chen YF, Chang CH, Huang ZN, Su YC, Chang SJ, Jan JS.

出 版 年:2018

分  類:抗癌

論文結論:The latent membrane protein 1 (LMP-1) of EBV constitutively activates the JAK/STAT signaling pathway and contributes to the proliferation of EBV-infected primary human B lymphocytes. Antcin H, an analog of the JAK2 inhibitor zhankuic acid A (ZAA), inhibits LMP-1-induced JAK/STAT related signaling and induces lymphoma cell line apoptosis. Moreover, antcin H enhances low-dose methotrexate (MTX) cytotoxicity against lymphoma cells. Treatment of antcin H with low-dose MTX significantly suppressed tumor growth and prolonged the survival of tumor-bearing mice.

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論文出處:Food Funct. 2018 Dec 13;9(12):6517-6525. doi: 10.1039/c8fo02079e.

論文名稱:Alpha-terpineol affects synthesis and antitumor activity of triterpenoids from Antrodia cinnamomea mycelia in solid-state culture.

作  者:Zhang Y, Li D , Wang Z , Zang W , Rao P , Liang Y , Mei Y .

出 版 年:2018

分  類:抗癌

論文結論:To enhance production of Antrodia cinnamomea triterpenoids (ACTs) from mycelia in solid-state culture, α-terpineol was added to the medium as an elicitor at an optimal concentration of 0.05 mL L-1. In assays of in vitro antitumor activity, ACTs-E (from culture with elicitor) produced stronger viability reduction in several tumor cell lines and stronger apoptosis induction in HeLa in a dose-dependent manner. ACTs-E strongly inhibited synthesis of topoisomerase I (TOP1) and tyrosyl-DNA phosphodiesterase I (TDP1), which are involved in DNA repair, at both transcriptional and protein levels.

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論文出處:Cancers (Basel). 2018 Dec 5;10(12). pii: E491. doi: 10.3390/cancers10120491.

論文名稱:The Disruption of the β-Catenin/TCF-1/STAT3 Signaling Axis by 4-Acetylantroquinonol B Inhibits the Tumorigenesis and Cancer Stem-Cell-Like Properties of Glioblastoma Cells, In Vitro and In Vivo.

作  者:Liu HW, Su YK, Bamodu OA, Hueng DY, Lee WH, Huang CC, Deng L, Hsiao M, Chien MH, Yeh CT, Lin CM.

出 版 年:2018

分  類:抗癌

論文結論:

4-Acetylantroquinonol B (4-AAQB), a bioactive isolate of Antrodia cinnamomea, suppresses the tumor-promoting catenin/LEF1/Stat3 signaling, and inhibited stem cells (CSCs)-induced oncogenic activities in Glioblastoma (GBM) in vitro, with in vivo validation; thus projecting 4-AAQB as a potent therapeutic agent for anti-GBM target therapy. human glioblastoma cell lines (U87MG, DBTRG-05MG). 
1. 4-AAQB significantly downregulated β-catenin and dysregulated the catenin/LEF1/Stat3 signaling axis in U87MG and DBTRG-05MG cells, dose-dependently. 4-AAQB⁻induced downregulation of catenin positively correlated with reduced Sox2 and Oct4 nuclear expression in the cells. 
2. 4-AAQB markedly reduced the viability of U87MG and DBTRG-05MG cells, effectively inhibited the nuclear catenin, limited the migration and invasion of GBM cells, with concurrent downregulation of catenin, vimentin, and slug; similarly, colony and tumorsphere formation was significantly attenuated with reduced expression of c-Myc and KLF4 proteins.

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論文出處:Front Pharmacol. 2018 Dec 17;9:1449. doi: 10.3389/fphar.2018.01449. eCollection 2018.

論文名稱:Antrodia camphorata Mycelia Exert Anti-liver Cancer Effects and Inhibit STAT3 Signaling in vitro and in vivo.

作  者:Zhu PL, Fu XQ, Li JK, Tse AK, Guo H, Yin CL, Chou JY, Wang YP, Liu YX, Chen YJ, Hossen MJ, Zhang Y, Pan SY, Zhao ZJ, Yu ZL.

出 版 年:2018

分  類:抗癌

論文結論:

The ethyl acetate fraction of an ethanolic extract of Antrodia camphorata mycelia (EEAC) reduced cell viability, induced apoptosis, and retarded migration and invasion in cultured hepatocellular carcinoma cells (HCC),  HepG2 and SMMC-7721. hepatocellular carcinoma cell lines (HepG2 and SMMC-7721).
1. EEAC downregulated protein levels of phosphorylated and total STAT3 and JAK2 (an upstream kinase of STAT3) in HCC cells. STAT3, but not JAK2, mRNA levels were decreased by EEAC. 
2. EEAC also lowered the protein level of nuclear STAT3, decreased the transcriptional activity of STAT3, and downregulated protein levels of STAT3-targeted molecules, including anti-apoptotic proteins Bcl-xL and Bcl-2, and invasion-related proteins MMP-2 and MMP-9. 
3. In SMMC-7721 cell-bearing mice, EEAC (100 mg/kg, i.g. for 18 days) significantly inhibited tumor growth. EEAC induced apoptosis and suppressed JAK2/STAT3 activation/phosphorylation in the tumors.

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論文出處:Front Pharmacol. 2018 Jul 18;9:780. doi: 10.3389/fphar.2018.00780. eCollection 2018.

論文名稱:Enhancing the Anticancer Activity of Antrodia cinnamomea in Hepatocellular Carcinoma Cells via Cocultivation With Ginger: The Impact on Cancer Cell Survival Pathways.

作  者:Chen SY, Lee YR, Hsieh MC, Omar HA, Teng YN, Lin CY, Hung JH

出 版 年:2018

分  類:抗癌

論文結論:

The cocultivation of Antrodia cinnamomea (AC) with ginger significantly induced the production of important triterpenoids and EACG was significantly more potent than EAC in targeting HCC cell lines.
1. Inhibited cancer cells growth via the induction of cell cycle arrest at G2/M phase and induction of apoptosis in Huh-7 and HepG2 cells and the activation of caspase-3. 
2. EACG modulated cyclin proteins expression and mitogen-activated protein kinase (MAPK) signaling pathways in favor of the inhibition of cancer cell survival. 

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論文出處:Sci Rep. 2018 Aug 27;8(1):12914. doi: 10.1038/s41598-018-31209-8.

論文名稱:Antrodia cinnamomea boosts the anti-tumor activity of sorafenib in xenograft models of human hepatocellular carcinoma.

作  者:Wu WD, Chen PS, Omar HA, Arafa EA, Pan HW, Jeng J, Hung JH

出 版 年:2018

分  類:抗癌

論文結論:

The ethanolic extracts of Antrodia cinnamomea (EAC) could effectively sensitize HCC cells to low doses of sorafenib, which was perceived via the ability of the combination to repress cell viability and to induce cell cycle arrest and apoptosis in HCC cells.
1. Enhanced sorafenib activity was mediated through targeting mitogen-activated protein (MAP) kinases, modulating cyclin proteins expression and inhibiting cancer cell invasion. 
2. The proposed combination significantly suppressed ectopic tumor growth in mice with high safety margins compared to single-agent treatment.

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論文出處:Int J Med Mushrooms. 2018;20(4):321-335. doi: 10.1615/IntJMedMushrooms.2018025836.

論文名稱:Autophagy Inhibition Enhances SPCA-1 Cell Proliferation Inhibition Induced by By-1 from the Stout Camphor Medicinal Mushroom, Taiwanofungus camphoratus (Agaricomycetes).

作  者:Yang H, Sun W, Zhang J, Zhang Y, Zhang H, Yang Y, Wu D, Liu Y, Qiankun Z, Min L, Wang WH, Jia W

出 版 年:2018

分  類:抗癌

論文結論:

By-1 (3-isobutyl-l-methoxy-4-[4'-(3-methylbut-2-enyloxy)phenyl]-1H-pyrrole-2,5-dione), a compound from submerged cultures of Taiwanofungus camphoratus, inhibited the growth of SPCA-1 cells by inducing cell cycle arrest and apoptosis.
1. suppress DNA synthesis, cause cell cycle arrest at the S phase, and induce apoptosis in a reactive oxygen species-dependent manner. 
2. The expression of caspase-3 and P53 was 4 times higher than that in untreated cells, and the antiapoptotic protein Bcl-2 was decreased 2 times compared with the protein in untreated cells. 

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論文出處:Int J Med Mushrooms. 2018;20(8):727-738. doi: 10.1615/IntJMedMushrooms.2018026983.

論文名稱:Compound of Stout Camphor Medicinal Mushroom, Taiwanofungus camphoratus (Agaricomycetes), Induces Protective Autophagy in SPCA-1 Cells through AMPK Inhibition-Independent Blockade of the Akt/mTOR Pathway.

作  者:Yang H, Zhang J, Zhang H, Yang Y, Liu Y, Sun W, Wang W, Jia W.

出 版 年:2018

分  類:抗癌

論文結論:By-1, a maleimide derivative isolated from Taiwanofungus camphoratus, treatment activated autophagy flux in human lung cancer SPCA-1 cells, which confirmed that autophagy was induced by By-1 treatment. By-1 treatment suppressed the Akt-mammalian target of rapamycin (mTOR) pathway and the AMP-activated protein kinase (AMPK) pathway.

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論文出處:Int J Biol Macromol. 2018 Aug 22. pii: S0141-8130(18)32863-0. doi: 10.1016/j.ijbiomac.2018.08.112. [Epub ahead of print]

論文名稱:Microelements induce changes in characterization of sulfated polysaccharides from Antrodia cinnamomea.

作  者:Lin TY, Tseng AJ, Chao CH, Lu MK

出 版 年:2018

分  類:抗癌

論文結論:Microelements play pivotal roles for fungal/plant development and end-use properties. CuSO4 and ZnSO4 increased the mycelium yields and promoted sulfated polysaccharides (SPS) production. Anticancer function studies showed that those SPSs inhibit the cell viability of lung cancer A549 cells via downregulation of EGFR signaling.

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論文出處:Carbohydr Polym. 2018 Dec 15;202:536-544. doi: 10.1016/j.carbpol.2018.09.009. Epub 2018 Sep 6.

論文名稱:Chemical identification of a sulfated glucan from Antrodia cinnamomea and its anti-cancer functions via inhibition of EGFR and mTOR activity.

作  者:Lu MK, Lin TY, Chang CC.

出 版 年:2018

分  類:抗癌

論文結論:AC-SPS-F3, a sulfated glucan from Antrodia cinnamomea, reduced lung cancer cell viability via inhibition of EGFR and mTOR activity.

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論文出處:Sci Rep. 2018 Nov 27;8(1):17424. doi: 10.1038/s41598-018-35780-y.

論文名稱:Antrodia cinnamomea induces autophagic cell death via the CHOP/TRB3/Akt/mTOR pathway in colorectal cancer cells.

作  者:Tsai DH, Chung CH, Lee KT.

出 版 年:2018

分  類:抗癌

論文結論:

Antrodia cinnamomea extracts showed cytotoxicity in HCT116, HT29, SW480, Caco-2 and, Colo205 colorectal cancer cells. Whole-genome expression profiling of Antrodia cinnamomea extracts in HCT116 cells was performed. Autophagic cell death via the CHOP/TRB3/Akt/mTOR pathway may represent a new mechanism of anti-colorectal cancer action by Antrodia cinnamomea.
1. Upregulated the expression of the endoplasmic reticulum stress marker CHOP and its downstream gene TRB3. 
2. Dephosphorylation of Akt and mTOR as well as autophagic cell death were observed. 
3. Demonstrated that Antrodia cinnamomea extracts significantly suppressed HCT116 tumour growth in nude mice.

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