學術論文


Academic papers

抗癌

論文出處:Cancers (Basel). 2018 Dec 31;11(1). pii: E34. doi: 10.3390/cancers11010034.

論文名稱:Antrocin Sensitizes Prostate Cancer Cells to Radiotherapy through Inhibiting PI3K/AKT and MAPK Signaling Pathways.

作  者:Chen YA, Tzeng DTW, Huang YP, Lin CJ, Lo UG, Wu CL, Lin H, Hsieh JT, Tang CH, Lai CH.

出 版 年:2018

分  類:抗癌

論文結論:Antrocin, a sesquiterpene lactone isolated from Antrodia cinnamomea, ensitizes prostate cancer (PCa) to radiation through constitutive suppression of IGF-1R downstream signaling. Antrocin downregulated PI3K/AKT and MAPK signaling pathways as well as suppressed type 1 insulin-like growth factor 1 receptor (IGF-1R)-mediated induction of β-catenin to regulate cell cycle and apoptosis.

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論文出處:Chin J Nat Med. 2019 Jan;17(1):33-42. doi: 10.1016/S1875-5364(19)30007-X.

論文名稱:Secondary metabolites of petri-dish cultured Antrodia camphorata and their hepatoprotective activities against alcohol-induced liver injury in mice.

作  者:Wu Y, Tian WJ, Gao S, Liao ZJ, Wang GH, Lo JM, Lin PH, Zeng DQ, Qiu DR, Liu XZ, Zhou M, Lin T, Chen HF.

出 版 年:2019

分  類:抗癌

論文結論:Nineteen triterpenes were isolated from the petri-dish cultured Antrodia camphorata (PDCA), and thirteen of them were the unique anthroic acids in Antrodia camphorata, including the main content antcin K. In mice alcohol-induced liver injury model, triglyceride (TG), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and malondialdehyde (MDA) had been reduced by the PDCA powder as well as the main content antcin K, which indicated that the PDCA could protect alcoholic liver injury in mice model and antcin K could be the effective component responsible for the hepatoprotective activities of PDCA against alcoholic liver diseases. triterpenes

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論文出處:Biomed Pharmacother. 2019 Jan;109:2262-2269. doi: 10.1016/j.biopha.2018.11.101. Epub 2018 Nov 28.

論文名稱:4-Acetylantroquinonol B from antrodia cinnamomea enhances immune function of dendritic cells against liver cancer stem cells.

作  者:Li TY, Chiang BH.

出 版 年:2019

分  類:抗癌

論文結論:

4-acetylantroquinonol B (4-AAQB), a ubiquinone derivative isolated from the mycelium of Antrodia cinnamomea, could inhibit liver cancer stem cell related manifestations and activate the antitumor ability of dendritic cells, and used for liver cancer prevention and immunotherapy.
1. 4-AAQB can inhibit EpCAM, AFP and related pathways of HepG2 cells. Significantly decreases the expression of β-catenin, inhibits the tumorigenicity and decreases the secretion of immune escape related cytokines. 
2. 4-AAQB can stimulate the proliferation of immune cells and promote the endocytosis of immature dendritic cells. 
3. When co-cultured immature dendritic cells with EpCAM+ HepG2 cells, 4-AAQB enhanced the expression of MHC class I and II on the surface of liver cancer stem cells and dendritic cells, increased the expression of costimulatory molecules CD80 of dendritic cells and cytokines related to immune activation. 

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論文出處:Carbohydr Polym. 2019 Apr 15;210:175-184. doi: 10.1016/j.carbpol.2019.01.078. Epub 2019 Jan 23.

論文名稱:A sulfated glucan from Antrodia cinnamomea reduces Slug expression through regulation of TGFβ/AKT/GSK3β axis in lung cancer.

作  者:Lin TY, Tseng AJ, Qiu WL, Chao CH, Lu MK.

出 版 年:2019

分  類:抗癌

論文結論:SGA, a sulfated glucan from Antrodia cinnamomea, suppressed tumor growth in vitro and in vivo. TGFβ signaling and overexpression of Slug are regarded as the critical events in lung tumor malignancy. SGA inhibited the TGFβ/FAK/AKT axis by inducing lipid-raft-mediated lysosome-dependent TGFβ receptor degradation, resulting in suppressing cancer cell viability and migration. 

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論文出處:Sci Rep. 2019 Mar 26;9(1):5145. doi: 10.1038/s41598-019-41653-9.

論文名稱:Antrodia cinnamomea induces anti-tumor activity by inhibiting the STAT3 signaling pathway in lung cancer cells.

作  者:Huang TT, Lan YW, Chen CM, Ko YF, Ojcius DM, Martel J, Young JD, Chong KY.

出 版 年:2019

分  類:抗癌

論文結論:

Antrodia cinnamomea ethanol extract (ACEE) inhibits lung tumor growth and metastasis by inducing apoptosis and by inhibiting the STAT3 signaling pathway in cancer cells.
1. ACEE treatment increased expression of p53 and Bax, as well as cleavage of caspase-3 and PARP, while reducing expression of survivin and Bcl-2. 
2. ACEE reduced the levels of JAK2 and phosphorylated STAT3 in LLC cells. 
3. In a murine allograft tumor model, oral administration of ACEE significantly inhibited LLC tumor growth and metastasis without affecting serum biological parameters or body weight. ACEE increased cleavage of caspase-3 in murine tumors, while decreasing STAT3 phosphorylation. ACEE reduced the growth of human tumor xenografts in nude mice. 

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論文出處:J Cell Physiol. 2019 Apr;234(4):4125-4139. doi: 10.1002/jcp.27222. Epub 2018 Aug 26.

論文名稱:Antrodia camphorata inhibits epithelial-to-mesenchymal transition by targeting multiple pathways in triple-negative breast cancers.

作  者:Hseu YC, Chang GR, Pan JY, Rajendran P, Mathew DC, Li ML, Liao JW, Chen WT, Yang HL

出 版 年:2019

分  類:抗癌

論文結論:

The fermented Antrodia camphorata (AC) exhibits potential for engendering cell-cycle arrest as well as prompting apoptosis and metastasis inhibition in triple-negative breast cancer (TNBC) cells.
1. Rversed the morphological changes (fibroblastic-to-epithelial phenotype) as well as the EMT by upregulating the observed E-cadherin expression.
2. Decrease the observed Wnt/β-catenin nuclear translocation through a pathway determined to be dependent on GSK3β. 
3. Inhibited the EMT by downregulating mesenchymal marker proteins like N-cadherin, vimentin, Snail, ZEB-1, and fibronectin; at that same time upregulating epithelial marker proteins like occludin and ZO-1.

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論文出處:Phytomedicine. 2019 Jan;52:70-78. doi: 10.1016/j.phymed.2018.09.213. Epub 2018 Sep 27.

論文名稱:Antrocin, a bioactive component from Antrodia cinnamomea, suppresses breast carcinogenesis and stemness via downregulation of β-catenin/Notch1/Akt signaling.

作  者:Chen JH, T H Wu A, T W Tzeng D, Huang CC, Tzeng YM, Chao TY.

出 版 年:2019

分  類:抗癌

論文結論:Antrocin, an active component of Antrodia cinnamomea, treatment suppressed the viability, migration colony formation and mammosphere generation. Antrocin-mediated anti-cancer effects were associated with the decreased expression of oncogenic and stemness markers such as β-catenin, Akt and Notch1.

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論文出處:Int J Mol Sci. 2019 Feb 15;20(4). pii: E833. doi: 10.3390/ijms20040833.

論文名稱:Antrodia cinnamomea, a Treasured Medicinal Mushroom, Induces Growth Arrest in Breast Cancer Cells, T47D Cells: New Mechanisms Emerge.

作  者:Chen YC, Liu YC, El-Shazly M, Wu TY, Chang JG, Wu YC.

出 版 年:2019

分  類:抗癌

論文結論:Ethanol extract of artificially cultured Antrodia cinnamomea (EEAC) inhibited breast cancer cells (T47D cells) proliferation mediated by cell cycle arrest at G1 phase as well induced autophagy. EEAC not only decreased the expression of the cell-cycle-related proteins but also increased the expression of transcription factor FOXO1, autophagic marker LC3 II, and p62. EEAC mediated endoplasmic reticulum stress by promoting the expression of IRE1 (inositol-requiring enzyme 1α), GRP78/Bip (glucose regulating protein 78), and CHOP (C/EBP homologous protein).

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