學術論文


Academic papers

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論文出處:J Food Sci. 2008 Sep;73(7):H179-85. doi: 10.1111/j.1750-3841.2008.00884.x. Epub 2008 Aug 18.

論文名稱:Ethanolic extracts of Antrodia cinnamomea mycelia fermented at varied times and scales have differential effects on hepatoma cells and normal primary hepatocytes.

作  者:Chen YS, Pan JH, Chiang BH, Lu FJ, Sheen LY.

出 版 年:2008

分  類:抗癌

論文結論:Ethanolic extracts from mycelia of Antrodia cinnamomea (AC) possessed high antihepatoma activity against Hep3B and HepG2 cells in rat.

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論文出處:Biosci Biotechnol Biochem. 2008 Jul;72(7):1704-13. Epub 2008 Jul 7.

論文名稱:Taiwanofungus camphoratus activates peroxisome proliferator-activated receptors and induces hypotriglyceride in hypercholesterolemic rats.

作  者:Suk FM, Lin SY, Chen CH, Yen SJ, Su CH, Liu DZ, Hou WC, Hung LF, Lin PJ, Liang YC.

出 版 年:2008

分  類:抗癌

論文結論:Taiwanofungus camphoratus might contain PPARgamma ligands and result in a hypotriglyceridemic effect, and that it also exhibits a liver protective activity in SD rats.

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論文出處:J Ethnopharmacol. 2008 Aug 13;118(3):387-95. doi: 10.1016/j.jep.2008.05.001. Epub 2008 May 7.

論文名稱:The adjuvant effects of Antrodia Camphorata extracts combined with anti-tumor agents on multidrug resistant human hepatoma cells.

作  者:Chang CY, Huang ZN, Yu HH, Chang LH, Li SL, Chen YP, Lee KY, Chuu JJ.

出 版 年:2008

分  類:抗癌

論文結論:Antrodia camphorata extract, when combined with anti-tumor agents, showed adjuvant antiproliferative effects on hepatoma cells (in vitro) and on xenografted cells in tumor-implanted nude mice (in vivo).

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論文出處:Food Chem Toxicol. 2008 Aug;46(8):2680-8. doi: 10.1016/j.fct.2008.04.036. Epub 2008 May 4.

論文名稱:Antrodia camphorata inhibits proliferation of human breast cancer cells in vitro and in vivo.

作  者:Hseu YC, Chen SC, Chen HC, Liao JW, Yang HL.

出 版 年:2008

分  類:抗癌

論文結論:Antrodia camphorata treatment induced cell cycle arrest and apoptosis of human breast cancer cells both in vitro and in vivo.

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論文出處:Chin J Physiol. 2008 Apr 30;51(2):78-84.

論文名稱:Effects of antrodia camphorata on viability, apoptosis, and [Ca2+]i in PC3 human prostate cancer cells.

作  者:Ho CM, Huang CC, Huang CJ, Cheng JS, Chen IS, Tsai JY, Jiann BP, Tseng PL, Kuo SJ, Jan CR.

出 版 年:2008

分  類:抗癌

論文結論:In human prostate cancer cells (PC3), Antrodia camphorata exerted multiple effects on viability and [Ca2+]i, caused apoptosis via pathways unrelated to [Ca2+]i signal and phosphorylation of ERK, JNK and p38 MAPKs.

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論文出處:Toxicol In Vitro. 2009 Apr;23(3):418-24. doi: 10.1016/j.tiv.2009.01.011. Epub 2009 Jan 22.

論文名稱:Compound MMH01 possesses toxicity against human leukemia and pancreatic cancer cells.

作  者:Chen YJ, Chou CJ, Chang TT.

出 版 年:2009

分  類:抗癌

論文結論:MMH01, isolated from Antrodia cinnamomea, markedly inhibited growth of human leukemia U937 and pancreatic cancer BxPC3 cells.

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論文出處:Arch Toxicol. 2009 Feb;83(2):121-9. doi: 10.1007/s00204-008-0337-3. Epub 2008 Aug 16.

論文名稱:Active extracts of wild fruiting bodies of Antrodia camphorata (EEAC) induce leukemia HL 60 cells apoptosis partially through histone hypoacetylation and synergistically promote anticancer effect of trichostatin A.

作  者:Lu MC, Du YC, Chuu JJ, Hwang SL, Hsieh PC, Hung CS, Chang FR, Wu YC

出 版 年:2009

分  類:抗癌

論文結論:Ethanol extract from wild fruiting bodies of Antrodia camphorata (EEAC) could induce HL 60 cells apoptosis via histone hypoacetylation, up-regulation of histone deacetyltransferase 1 (HDAC 1), and down-regulation of histone acetyltransferase activities including GCN 5, CBP and PCAF. Combined treatment with histone deacetylase inhibitor, trichostatin A (TSA) caused synergistic inhibition of cell growth and increase of apoptotic induction. EEAC may be a potential chemotherapeutic adjuvant.

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論文出處:Am J Chin Med. 2009;37(4):771-83.

論文名稱:The augmented anti-tumor effects of Antrodia camphorata co-fermented with Chinese medicinal herb in human hepatoma cells.

作  者:Li SL, Huang ZN, Hsieh HH, Yu WC, Tzeng WY, Lee GY, Chen YP, Chang CY, Chuu JJ.

出 版 年:2009

分  類:抗癌

論文結論:A novel strategy of fermenting Antrodia camphorata with Chinese medicinal herb (AC-CF), which augmented their anti-tumor effects in human hepatoma HepG2 cells as compared with two other traditional ones. (Extracts from fruiting bodies , AC-FB, or solid-state culture, AC-SS, of Antrodia camphorata.)

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論文出處:J Ethnopharmacol. 2009 Jan 21;121(2):194-212. doi: 10.1016/j.jep.2008.10.039. Epub 2008 Nov 17.

論文名稱:Niuchangchih (Antrodia camphorata) and its potential in treating liver diseases.

作  者:Ao ZH1, Xu ZH, Lu ZM, Xu HY, Zhang XM, Dou WF

出 版 年:2009

分  類:抗癌

論文結論:This review will address the protective effects of Niuchangchih on the pathological development of liver diseases, and the underlying mechanisms of action are also discussed.

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論文出處:Cancer Lett. 2009 Nov 18;285(1):73-9. doi: 10.1016/j.canlet.2009.05.002. Epub 2009 May 23.

論文名稱:Cytotoxic triterpenes from Antrodia camphorata and their mode of action in HT-29 human colon cancer cells.

作  者:Yeh CT, Rao YK, Yao CJ, Yeh CF, Li CH, Chuang SE, Luong JH, Lai GM, Tzeng YM

出 版 年:2009

分  類:抗癌

論文結論:Five lanostane (2, 3, 4, 6 and 8) and three ergostane-type (1, 5 and 7) triterpenes isolated from the fruiting bodies of Antrodia camphorata. The three zhankuic acids, 1, 5 and 7 displayed the most potent cytotoxic effect. Induce apoptosis in HT-29 and SW-480 cells, as confirmed by sub-G1 cell cycle arrest. (The expression of apoptosis-associated proteins poly-(ADP-ribose) polymerase cleavage, Bcl-2 and procaspase-3 were suppressed.)

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論文出處:Chin J Physiol. 2009 Jun 30;52(3):128-35.

論文名稱:Effects of Antrodia camphorata extracts on the viability, apoptosis, [Ca2+]i, and MAPKs phosphorylation of OC2 human oral cancer cells.

作  者:Huang CC, Cheng HH, Wang JL, Cheng JS, Chai KL, Fang YC, Kuo CC, Chu ST, Ho CM, Lin KL, Tsai JY, Jan CR

出 版 年:2009

分  類:抗癌

論文結論:Antrodia camphorata exerted multiple effects on their viability and [Ca2+]i, induced their ERK and JNK MAPK phosphorylation, and probably evoked their apoptosis.

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論文出處:J Sci Food Agric. 2010 Aug 15;90(10):1739-44. doi: 10.1002/jsfa.4010.

論文名稱:The 4-acetylantroquinonol B isolated from mycelium of Antrodia cinnamomea inhibits proliferation of hepatoma cells.

作  者:Lin YW, Pan JH, Liu RH, Kuo YH, Sheen LY, Chiang BH.

出 版 年:2010

分  類:抗癌

論文結論:4-Acetylantroquinonol B, a major antihepatoma compound in HepG2 cells, was isolate from the submerged fermentation mycelium of Antrodia cinnamomea.

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論文出處:Biochem Pharmacol. 2010 Jan 15;79(2):162-71. doi: 10.1016/j.bcp.2009.08.022. Epub 2009 Aug 31.

論文名稱:Antroquinonol displays anticancer potential against human hepatocellular carcinoma cells: a crucial role of AMPK and mTOR pathways.

作  者:Chiang PC, Lin SC, Pan SL, Kuo CH, Tsai IL, Kuo MT, Wen WC, Chen P, Guh JH

出 版 年:2010

分  類:抗癌

論文結論:Antroquinonol (isolated from Antrodia camphorate) displays anticancer activity against HCCs through AMPK activation and inhibition of mTOR translational pathway, leading to G1 arrest of the cell-cycle and subsequent cell apoptosis.

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論文出處:Chem Res Toxicol. 2010 Jul 19;23(7):1256-67. doi: 10.1021/tx100116a.

論文名稱:Methyl antcinate A from Antrodia camphorata induces apoptosis in human liver cancer cells through oxidant-mediated cofilin- and Bax-triggered mitochondrial pathway.

作  者:Hsieh YC, Rao YK, Wu CC, Huang CY, Geethangili M, Hsu SL, Tzeng YM.

出 版 年:2010

分  類:抗癌

論文結論:Antcin A, antcin C, and methyl antcinate A (MAA) were isolated from Antrodia camphorata. That inhibit the proliferation of human liver cancer cell lines Huh7, HepG2, and Hep3B. The compound MAA was a more potent cytotoxic agent than antcins A and C.

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論文出處:J Ethnopharmacol. 2010 Feb 17;127(3):652-61. doi: 10.1016/j.jep.2009.12.008. Epub 2009 Dec 6.

論文名稱:Apoptotic effects of a high performance liquid chromatography (HPLC) fraction of Antrodia camphorata mycelia are mediated by down-regulation of the expressions of four tumor-related genes in human non-small cell lung carcinoma A549 cell.

作  者:Chan YY, Chang CS, Chien LH, Wu TF

出 版 年:2010

分  類:抗癌

論文結論:The anti-cancer activity of Antrodia camphorata might be due to multiple active metabolites, which work together to induce cell apoptosis via various pathways.

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