學術論文


Academic papers

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論文出處:J Nat Prod. 2012 Nov 26;75(11):2016-44. doi: 10.1021/np300412h. Epub 2012 Oct 23.

論文名稱:Lanostanoids from fungi: a group of potential anticancer compounds.

作  者:Ríos JL, Andújar I, Recio MC, Giner RM.

出 版 年:2012

分  類:抗癌

論文結論:This review showed that lanostanes are a group of tetracyclic triterpenoids derived from lanosterol. They have great potential as anticancer agents because of their cytotoxic or apoptotic effects. To arrest the cell cycle in the G1 phase, increase levels of p53 and Bax, or inhibit the phosphorylation of Erk1/2 or the activation of NF-κB and AP-1. Have inhibitory effects on the growth of androgen prostate carcinoma through increasing the expression of p21, which activates the tumor suppressor protein p53.

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論文出處:Phytochemistry. 2012 Dec;84:177-83. doi: 10.1016/j.phytochem.2012.08.011. Epub 2012 Sep 18.

論文名稱:Lanostane triterpenoids and sterols from Antrodia camphorata.

作  者:Huang HC, Liaw CC, Yang HL, Hseu YC, Kuo HT, Tsai YC, Chien SC, Amagaya S, Chen YC, Kuo YH.

出 版 年:2012

分  類:抗癌

論文結論:Four lanostane triterpenes (3,7,11-trioxo-5α-lanosta-8,24(E)-dien-26-oic acid, methyl 11α-3,7-dioxo-5α-lanosta-8,24(E)-dien-26-oate, methyl 3,7,11,12,15,23-hexaoxo-5α-lanost-8-en-26-oate, and ethyl 3,7,11,12,15,23-hexaoxo-5α-lanost-8-en-26-oate) and two sterols (camphosterol A and (14α,22E)-14-hydroxyergosta-7,22-diene-3,6-dione) were isolated from a mixture of fruiting bodies and mycelia of Antrodia camphorata. Six compounds were have activity for cytotoxicity against human tumor cell lines.

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論文出處:Anticancer Res. 2012 Jul;32(7):2727-34.

論文名稱:Anticancer effects of eleven triterpenoids derived from Antrodia camphorata.

作  者:Lee YP, Tsai WC, Ko CJ, Rao YK, Yang CR, Chen DR, Yang MH, Yang CC, Tzeng YM.

出 版 年:2012

分  類:抗癌

論文結論:These triterpenoids (methyl antcinate A, methyl antcinate B, dehydroeburicoic acid, and 15α-acetyl-dehydrosulfurenic acid) may lead to the development of more potent anticancer drugs.

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論文出處:Phytomedicine. 2012 Jun 15;19(8-9):788-96. doi: 10.1016/j.phymed.2012.03.014. Epub 2012 Apr 18.

論文名稱:Antileukemia component, dehydroeburicoic acid from Antrodia camphorata induces DNA damage and apoptosis in vitro and in vivo models.

作  者:Du YC, Chang FR, Wu TY, Hsu YM, El-Shazly M, Chen CF, Sung PJ, Lin YY, Lin YH, Wu YC, Lu MC.

出 版 年:2012

分  類:抗癌

論文結論:Five triterpenoids, antcin K, antcin C, zhankuic acid C, zhankuic acid A, and dehydroeburicoic acid (DeEA) were isolated from triterpenoid-rich fraction (FEA) of ethanolic extract of Antrodia camphorata and characterized by high performance liquid chromatography (HPLC). The dehydroeburicoic acid (DeEA) was the most potent cytotoxic component. Activated DNA damage and apoptosis biomarkers similar to FEA.

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論文出處:J Tradit Complement Med. 2012 Oct;2(4):312-22.

論文名稱:Eburicoic Acid, an Active Triterpenoid from the Fruiting Bodies of Basswood Cultivated Antrodia cinnamomea, Induces ER Stress-Mediated Autophagy in Human Hepatoma Cells.

作  者:Su YC, Liu CT, Chu YL, Raghu R, Kuo YH, Sheen LY

出 版 年:2012

分  類:抗癌

論文結論:Eburicoic acid, the second most abundant triterpenoid from the fruiting bodies of basswood cultivated Antrodia cinnamomea, has significant anti-liver cancer effects and more distinctive mechanisms.

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論文出處:J Tradit Complement Med. 2012 Oct;2(4):284-94.

論文名稱:Protective effects of Antrodia cinnamomea against liver injury.

作  者:Liu YW, Lu KH, Ho CT, Sheen LY

出 版 年:2012

分  類:抗癌

論文結論:The potential application of Antrodia cinnamomea in preventing and treating liver diseases and its potential to be developed into health foods or new drugs.

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論文出處:Phytomedicine. 2012 Jun 15;19(8-9):768-78. doi: 10.1016/j.phymed.2012.02.016. Epub 2012 Mar 29.

論文名稱:Ethanol extracts of fruiting bodies of Antrodia cinnamomea exhibit anti-migration action in human adenocarcinoma CL1-0 cells through the MAPK and PI3K/AKT signaling pathways.

作  者:Chen YY, Chou PY, Chien YC, Wu CH, Wu TS, Sheu MJ.

出 版 年:2012

分  類:抗癌

論文結論:Ethanol extract of fruiting bodies of Antrodia cinnamomea (EEAC) exerted inhibitory effect on migration and motility in CL1-0 cells.

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論文出處:Evid Based Complement Alternat Med. 2012;2012:378415. doi: 10.1155/2012/378415. Epub 2012 Feb 21.

論文名稱:Ethanol extracts of fruiting bodies of Antrodia cinnamomea suppress CL1-5 human lung adenocarcinoma cells migration by inhibiting matrix metalloproteinase-2/9 through ERK, JNK, p38, and PI3K/Akt signaling pathways.

作  者:Chen YY, Liu FC, Chou PY, Chien YC, Chang WS, Huang GJ, Wu CH, Sheu MJ.

出 版 年:2012

分  類:抗癌

論文結論:Ethanol extract of fruiting bodies of Antrodia cinnamomea (EEAC) induced FAK phosphorylation and exhibited its antimigration activities via the PI3K/AKT and MAPK signalings in CL1-5 cells.

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論文出處:J Cancer Res Ther. 2012 Oct-Dec;8(4):532-6. doi: 10.4103/0973-1482.106529.

論文名稱:The in vivo antitumor effects on human COLO 205 cancer cells of the 4,7-dimethoxy-5-(2-propen-1-yl)-1,3-benzodioxole (apiole) derivative of 5-substituted 4,7-dimethoxy-5-methyl-l,3-benzodioxole (SY-1) isolated from the fruiting body of Antrodia camphorate.

作  者:Wei PL, Tu SH, Lien HM, Chen LC, Chen CS, Wu CH, Huang CS, Chang HW, Chang CH, Tseng H, Ho YS.

出 版 年:2012

分  類:抗癌

論文結論:4,7-dimethoxy-5-(2-propen-1-yl)-1,3-benzodioxole (apiole)  is a chemical derivative of 4,7-dimethoxy-5-methyl-l,3-benzodioxole (SY-1), SY-1 has been isolated from dried Antrodia camphorata fruiting bodies. The antitumor effects of apiole against colon tumors in an in vivo xenograft model.

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論文出處:J Agric Food Chem. 2012 Apr 11;60(14):3612-8. doi: 10.1021/jf300221g. Epub 2012 Mar 29.

論文名稱:In vivo antitumor effects of 4,7-dimethoxy-5-methyl-1,3-benzodioxole isolated from the fruiting body of Antrodia camphorata through activation of the p53-mediated p27/Kip1 signaling pathway.

作  者:Tu SH, Wu CH, Chen LC, Huang CS, Chang HW, Chang CH, Lien HM, Ho YS.

出 版 年:2012

分  類:抗癌

論文結論:4,7-dimethoxy-5-methyl-1,3-benzodioxole (SY-1) was isolated from Antrodia camphorata (AC) fruiting bodies. That SY-1 profoundly decreased the growth of COLO-205 human colon cancer cell tumor xenografts in an athymic nude mouse model.

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論文出處:Eur J Pharmacol. 2012 Apr 5;680(1-3):8-15. doi: 10.1016/j.ejphar.2012.01.032. Epub 2012 Feb 10.

論文名稱:Inhibition of cell survival, cell cycle progression, tumor growth and cyclooxygenase-2 activity in MDA-MB-231 breast cancer cells by camphorataimide B.

作  者:Lin WL, Lee YJ, Wang SM, Huang PY, Tseng TH.

出 版 年:2012

分  類:抗癌

論文結論:Camphorataimide B (isolated from mycelium of Antrodia camphorate) decreased the cell viability, triggered apoptosis and blocked cell cycle progression of MDA-MB-231 breast cancer cells.

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論文出處:Evid Based Complement Alternat Med. 2012;2012:702857. doi: 10.1155/2012/702857. Epub 2012 Jun 3.

論文名稱:Inhibition of Cell Growth and Induction of Apoptosis by Antrodia camphorata in HER-2/neu-Overexpressing Breast Cancer Cells through the Induction of ROS, Depletion of HER-2/neu, and Disruption of the PI3K/Akt Signaling Pathway.

作  者:Lee CC, Yang HL, Way TD, Kumar KJ, Juan YC, Cho HJ, Lin KY, Hsu LS, Chen SC, Hseu YC.

出 版 年:2012

分  類:抗癌

論文結論:The anticancer activity of Antrodia camphorata (AC) against human HER-2/neu-overexpressing breast cancers.

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論文出處:J Nutr Biochem. 2012 Aug;23(8):900-7. doi: 10.1016/j.jnutbio.2011.04.015. Epub 2011 Aug 12.

論文名稱:Antroquinonol, a natural ubiquinone derivative, induces a cross talk between apoptosis, autophagy and senescence in human pancreatic carcinoma cells.

作  者:Yu CC, Chiang PC, Lu PH, Kuo MT, Wen WC, Chen P, Guh JH.

出 版 年:2012

分  類:抗癌

論文結論:Antroquinonol, a ubiquinone derivative isolated from Antrodia camphorata, induced the inhibition of cell proliferation in pancreatic cancer PANC-1 and AsPC-1 cells. Induced G1 arrest of the cell cycle and a subsequent apoptosis.

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論文出處:Am J Chin Med. 2013;41(5):1169-80. doi: 10.1142/S0192415X13500791.

論文名稱:Cytotoxic effect and induction of apoptosis in human cervical cancer cells by Antrodia camphorata.

作  者:Yang PY, Hu DN, Liu FS.

出 版 年:2013

分  類:抗癌

論文結論:The crude extract of Antrodia camphorata is cytotoxic to cervical cancer cells (HeLa and C-33A) through apoptotic mechanisms.

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論文出處:Curr Top Med Chem. 2013;13(21):2791-806.

論文名稱:Mycotherapy of cancer: an update on cytotoxic and antitumor activities of mushrooms, bioactive principles and molecular mechanisms of their action.

作  者:Popović V, Živković J, Davidović S, Stevanović M, Stojković D.

出 版 年:2013

分  類:抗癌

論文結論:The Antrodia camphorata and Ganoderma lucidium extracts and isolated bioactive compounds reporting the heteropolysaccharides, β-glucans, α-glucans, proteins, complexes of polysaccharides with proteins, fatty acids, nucleoside antagonists, terpenoids, sesquiterpenes, lanostanoids, sterols and phenolic acids as antitumor agents. Also, molecular mechanisms of cytotoxicity against different cancer cell lines are discussed in this review.

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