學術論文


Academic papers

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論文出處:J Med Food. 2013 Aug;16(8):681-91. doi: 10.1089/jmf.2012.2605.

論文名稱:Antrodia camphorata grown on germinated brown rice inhibits HT-29 human colon carcinoma proliferation through inducing G0/G1 phase arrest and apoptosis by targeting the β-catenin signaling.

作  者:Park DK, Lim YH, Park HJ.

出 版 年:2013

分  類:抗癌

論文結論:Antrodia camphorata grown on germinated brown rice (CBR) EtOAc fraction showed the strongest inhibitory activity against HT-29 human colon cancer cell and CT-26 human rectum cancer cell proliferation.

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論文出處:Integr Cancer Ther. 2013 Mar;12(2):153-64. doi: 10.1177/1534735412442379. Epub 2012 Jul 12.

論文名稱:Taiwanofungus camphoratus (Syn Antrodia camphorata) extract and amphotericin B exert adjuvant effects via mitochondrial apoptotic pathway.

作  者:Chen LY, Sheu MT, Liao CK, Tsai FC, Kao WY, Su CH.

出 版 年:2013

分  類:抗癌

論文結論:Ethanol extract of solid-state cultivated Taiwanofungus camphoratus (TCEE) and Amphotericin B (AmB) enhanced cell cycle arrest and apoptosis. The antitumor efficacy may be mediated by alterations in the levels of key proteins that regulate the cell cycle and apoptosis. Our results indicate the novel possibility that the drug combination of a conventional antifungal agent and a traditional Chinese medicine may serve as an alternative medicine for patients suffering from malignancies.

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論文出處:Evid Based Complement Alternat Med. 2013;2013:296082. doi: 10.1155/2013/296082. Epub 2013 Dec 11.

論文名稱:Antcin C from Antrodia cinnamomea Protects Liver Cells Against Free Radical-Induced Oxidative Stress and Apoptosis In Vitro and In Vivo through Nrf2-Dependent Mechanism.

作  者:Gokila Vani M, Kumar KJ, Liao JW, Chien SC, Mau JL, Chiang SS, Lin CC, Kuo YH, Wang SY.

出 版 年:2013

分  類:抗癌

論文結論:Antcin C, a steroid-like compound isolated from Antrodia cinnamomea, could protect liver cells from oxidative stress and cell death via Nrf2/ARE activation.

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論文出處:PLoS One. 2013 Dec 17;8(12):e82751. doi: 10.1371/journal.pone.0082751. eCollection 2013.

論文名稱:Global assessment of Antrodia cinnamomea-induced microRNA alterations in hepatocarcinoma cells.

作  者:Chen YJ, Thang MW, Chan YT, Huang YF, Ma N, Yu AL, Wu CY, Hu ML, Chiu KP

出 版 年:2013

分  類:抗癌

論文結論:Antrodia cinnamomea indiscriminately induced a global downregulation of miRNAs by simultaneously inhibiting the key enzymes involved in miRNA maturation and activating XRN2 protein involved in miRNA degradation in SK-Hep-1 cells. Collapsing of the miRNA system together with downregulation of cell growth and survival pathways and activation of JNK signaling unleash the extrinsic and intrinsic apoptosis pathways, leading to the cancer cell death.

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論文出處:Chin Med. 2013 Nov 1;8(1):21. doi: 10.1186/1749-8546-8-21.

論文名稱:Current evidence for the hepatoprotective activities of the medicinal mushroom Antrodia cinnamomea.

作  者:Yue PY, Wong YY, Wong KY, Tsoi YK, Leung KS.

出 版 年:2013

分  類:抗癌

論文結論:This review focuses on the inhibitory effects of Antrodia cinnamomea (AC) on hepatitis, hepatocarcinoma, and alcohol-induced liver diseases (e.g., fatty liver, fibrosis). The relevant biochemical and molecular mechanisms in vitro and in vivo are addressed.

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論文出處:J Agric Food Chem. 2013 Sep 25;61(38):9160-5. doi: 10.1021/jf402187q. Epub 2013 Sep 10.

論文名稱:Enhancement of 4-acetylantroquinonol B production by supplementation of its precursor during submerged fermentation of Antrodia cinnamomea.

作  者:Chiang CC, Huang TN, Lin YW, Chen KH, Chiang BH.

出 版 年:2013

分  類:抗癌

論文結論:Oct-1-en-3-ol, linalool, methyl phenylacetate, nerolidol, γ-cadinene and 2,4,5-trimethoxybenzaldehyde (TMBA) are  major volatile compounds of Antrodia cinnamomea. Used TMBA and nerolidol during fermentation, could increase the production of 4-acetylantroquinonol B and enhance the antiproliferation activity on hepatocellular cancer cells HepG2.

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論文出處:Evid Based Complement Alternat Med. 2013;2013:569737. doi: 10.1155/2013/569737. Epub 2013 Mar 6.

論文名稱:Medicinal Fungus Antrodia cinnamomea Inhibits Growth and Cancer Stem Cell Characteristics of Hepatocellular Carcinoma.

作  者:Liu YM, Liu YK, Lan KL, Lee YW, Tsai TH, Chen YJ.

出 版 年:2013

分  類:抗癌

論文結論:Mycelial fermentation broth of Antrodia cinnamomea (AC-MFB) could inhibit the growth of hepatocellular carcinoma (HCC) in murine 1MEA.7R.1 cells and human HA22T/VGH HCC cells. And inhibited the cellular viability, migration, and tube formation activity in cancer stem cells (EA. hy926 and SVEC4-10 endothelial cells).

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論文出處:Carcinogenesis. 2013 Dec;34(12):2918-28. doi: 10.1093/carcin/bgt255. Epub 2013 Jul 23.

論文名稱:A sesquiterpene lactone antrocin from Antrodia camphorata negatively modulates JAK2/STAT3 signaling via microRNA let-7c and induces apoptosis in lung cancer cells.

作  者:Yeh CT, Huang WC, Rao YK, Ye M, Lee WH, Wang LS, Tzeng DT, Wu CH, Shieh YS, Huang CY, Chen YJ, Hsiao M, Wu AT, Yang Z, Tzeng YM.

出 版 年:2013

分  類:抗癌

論文結論:Antrocin may be a potential therapeutic agent for human lung cancer cells (H441 and H1975) through constitutive inhibition of JAK2/STAT3 pathway.

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論文出處:Molecules. 2013 Feb 26;18(3):2539-48. doi: 10.3390/molecules18032539.

論文名稱:Methyl Antcinate A suppresses the population of cancer stem-like cells in MCF7 human breast cancer cell line.

作  者:Peng CY, Fong PC, Yu CC, Tsai WC, Tzeng YM, Chang WW.

出 版 年:2013

分  類:抗癌

論文結論:Methyl antcinate A (MAA) has anti-CSCs (Cancer stem cells) activity and is worthy of future development of potent anticancer agents.

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論文出處:J Ethnopharmacol. 2013 Jun 21;148(1):254-65. doi: 10.1016/j.jep.2013.04.023. Epub 2013 Apr 22.

論文名稱:The anti-cancer activity of Antrodia camphorata against human ovarian carcinoma (SKOV-3) cells via modulation of HER-2/neu signaling pathway.

作  者:Yang HL, Lin KY, Juan YC, Kumar KJ, Way TD, Shen PC, Chen SC, Hseu YC.

出 版 年:2013

分  類:抗癌

論文結論:Antrodia camphorata may exert anti-tumor activity against human ovarian carcinoma by suppressing HER-2/neu signaling pathways.

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論文出處:Evid Based Complement Alternat Med. 2014;2014:246748. doi: 10.1155/2014/246748. Epub 2014 Nov 6.

論文名稱:Coenzyme Q0 from Antrodia cinnamomea in Submerged Cultures Induces Reactive Oxygen Species-Mediated Apoptosis in A549 Human Lung Cancer Cells.

作  者:Chung CH, Yeh SC, Chen CJ, Lee KT

出 版 年:2014

分  類:抗癌

論文結論:2,3-dimethoxy-5-methyl-1,4-benzoquinone (coenzyme Q0; CoQ0) derived from Antrodia cinnamomea submerged culture filtrates exerts its anticancer effect through the induction of ROS-mediated apoptosis in A549 human lung cancer cells.

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論文出處:Molecules. 2014 Feb 21;19(2):2546-56. doi: 10.3390/molecules19022546.

論文名稱:In vivo and in vitro anti-tumor effects of fungal extracts.

作  者:Wu HT, Lu FH, Su YC, Ou HY, Hung HC, Wu JS, Yang YC, Chang CJ

出 版 年:2014

分  類:抗癌

論文結論:Ethanol extracts of Taiwanofungus camphorates exert anti-cancer activities, and water extracts show lower inhibitory activities in vitro. Ethanol extract also decreased tumor size and increased the lifespan in mice bearing sarcoma-180 tumors.

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論文出處:Molecules. 2014 Dec 19;19(12):21378-85. doi: 10.3390/molecules191221378.

論文名稱:New and Cytotoxic Components from Antrodia camphorata.

作  者:Lee TH, Chen CC, Chen JJ, Liao HF, Chang HS, Sung PJ, Tseng MH, Wang SY, Ko HH, Kuo YH

出 版 年:2014

分  類:抗癌

論文結論:The solid-state cultured products of Antrodia camphorata, 1(10→6)abeo-ergosta-5,7,9,22-tetraen-3α-ol, citreoanthrasteroid B, dankasterones A and dankasterone B  were purified by a series of column chromatography. They showed significant cytotoxicity toward murine colorectal CT26 and human leukemia K562 cancer cell lines.

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論文出處:Biomed Pharmacother. 2014 Oct;68(8):1007-14. doi: 10.1016/j.biopha.2014.09.008. Epub 2014 Sep 26.

論文名稱:Antroquinonol blocks Ras and Rho signaling via the inhibition of protein isoprenyltransferase activity in cancer cells.

作  者:Ho CL, Wang JL, Lee CC, Cheng HY, Wen WC, Cheng HH, Chen MC

出 版 年:2014

分  類:抗癌

論文結論:Antroquinonol inhibited Ras and Ras-related GTP-binding protein activation through inhibition of protein isoprenyl transferase activity, leading to activation of autophagy and associated mode of cell death in cancer cells.

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論文出處:J Nat Prod. 2014 Jan 24;77(1):118-24. doi: 10.1021/np400741s. Epub 2014 Jan 3.

論文名稱:Antcamphins A-L, ergostanoids from Antrodia camphorata.

作  者:Huang Y, Lin X, Qiao X, Ji S, Liu K, Yeh CT, Tzeng YM, Guo D, Ye M.

出 版 年:2014

分  類:抗癌

論文結論:Twelve ergostanoids, antcamphins A-L (1-12), together with 20 known triterpenoids, were isolated from fruiting bodies of Antrodia camphorata. Compounds 1 and 2 represent the first examples of norergostanes, and compounds 3 and 4 are the first pair of cis-trans isomers of ergostane-type triterpenoids containing an aldehyde group. Compounds 5-12 are four pairs of C-25 epimers. These triterpenoids exhibited weak cytotoxic activities against MDA-MB-231 breast cancer cells and A549 lung cancer cells.

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