學術論文


Academic papers

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論文出處:Int J Biol Macromol. 2015 Mar;74:476-82. doi: 10.1016/j.ijbiomac.2015.01.004. Epub 2015 Jan 10.

論文名稱:Anti-metastatic effects of antrodan, the Antrodia cinnamomea mycelia glycoprotein, in lung carcinoma cells.

作  者:Fa KN, Yang CM, Chen PC, Lee YY, Chyau CC, Hu ML

出 版 年:2015

分  類:抗癌

論文結論:Antrodan was isolated from Antrodia cinnamomea mycelia, significantly inhibit invasion and migration of Lewis lung carcinoma (LLC) cells.

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論文出處:Mol Clin Oncol. 2015 Nov;3(6):1375-1380. Epub 2015 Sep 15.

論文名稱:A phase I multicenter study of antroquinonol in patients with metastatic non-small-cell lung cancer who have received at least two prior systemic treatment regimens, including one platinum-based chemotherapy regimen.

作  者:Lee YC, Ho CL, Kao WY, Chen YM

出 版 年:2015

分  類:抗癌

論文結論:This first in-human phase I study of antroquinonol included patients with metastatic non-small-cell lung cancer. An open-label, dose escalation, pharmacokinetic (PK) study was conducted to determine the maximum tolerable dose (MTD), dose-limiting toxicities (DLTs), and safety/tolerability and preliminary efficacy profiles of antroquinonol. Treatment with antroquinonol was generally safe and well tolerated, without DLTs. And the recommended dose level for a phase II study is ≥600 mg daily.

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論文出處:Biomed Res Int. 2015;2015:604385. doi: 10.1155/2015/604385. Epub 2015 Jun 17.

論文名稱:Mushroom β-Glucan May Immunomodulate the Tumor-Associated Macrophages in the Lewis Lung Carcinoma.

作  者:Wang WJ, Wu YS, Chen S, Liu CF, Chen SN

出 版 年:2015

分  類:抗癌

論文結論:The efficacious effect of Antrodia camphorata polysaccharides for ameliorating the immune suppression in the tumor microenvironment. Increased M1 phenotype of tumor-associated macrophages and attenuated M2 phenotype of tumor-associated macrophages. And IL-12 and IFN-γ mRNA expression were significantly increased, but IL-6, IL-10, COX-2, and TGF-β mRNA expression were reduced.

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論文出處:Nat Prod Bioprospect. 2015 Oct;5(5):237-46. doi: 10.1007/s13659-015-0072-4. Epub 2015 Sep 28.

論文名稱:Intestinal Absorption of Ergostane and Lanostane Triterpenoids from Antrodia cinnamomea Using Caco-2 Cell Monolayer Model.

作  者:Wang Q, Qiao X, Qian Y, Li ZW, Tzeng YM, Zhou DM, Guo DA, Ye M

出 版 年:2015

分  類:抗癌

論文結論:Used intestinal Caco-2 cell monolayer model to reveal the intestinal absorption property of 14 representative triterpenoids from Antrodia cinnamomea.

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論文出處:Int J Nanomedicine. 2015 Dec 2;10:7265-74. doi: 10.2147/IJN.S95194. eCollection 2015.

論文名稱:Physical characterization and in vivo pharmacokinetic study of self-assembling amphotericin B-loaded lecithin-based mixed polymeric micelles.

作  者:Chen YC, Su CY, Jhan HJ, Ho HO, Sheu MT

出 版 年:2015

分  類:抗癌

論文結論:Pretreatment of ethanolic extract of Taiwanofungus camphoratus followed by AmB to HT29 colon cancer cells, the 50% inhibitory concentration of AmB solution was 12 μg/mL, whereas that of Ambicelles was 1 μg/mL, indicating that Ambicelles exerted a greater synergistic anticancer effect. (AmB, amphotericin B; Ambicelles, composed of AmB:lecithin:DSPE-PEG2K in a 1:1:10 weight ratio)

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論文出處:Toxicol Appl Pharmacol. 2015 Oct 15;288(2):258-68. doi: 10.1016/j.taap.2015.07.025. Epub 2015 Jul 30.

論文名稱:4-Acetylantroquinonol B inhibits colorectal cancer tumorigenesis and suppresses cancer stem-like phenotype.

作  者:Chang TC, Yeh CT, Adebayo BO, Lin YC, Deng L, Rao YK, Huang CC, Lee WH, Wu AT, Hsiao M, Wu CH, Wang LS, Tzeng YM

出 版 年:2015

分  類:抗癌

論文結論:4-Acetylantroquinonol B (4-AAQB), closely related to the better known antroquinonol, is a bioactive isolate of the mycelia of Antrodia camphorata, have anti-inflammatory, hypoglycemic, vasorelaxative, antiproliferative activity and attenuating stemness-related chemoresistance.

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論文出處:PLoS One. 2015 Feb 6;10(2):e0117111. doi: 10.1371/journal.pone.0117111. eCollection 2015.

論文名稱:Antrodin C inhibits epithelial-to-mesenchymal transition and metastasis of breast cancer cells via suppression of Smad2/3 and β-catenin signaling pathways.

作  者:Kumar KJ, Vani MG, Chueh PJ, Mau JL, Wang SY

出 版 年:2015

分  類:抗癌

論文結論:Antrodin C (ADC), a maleimide derivative isolated from Antrodia cinnamomea, attenuates the TGF-β1-induced Epithelial-to-mesenchymal transition (EMT), migration and invasion of human breast carcinoma through the suppression of Smad2/3 and β-catenin signaling pathways.

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論文出處:Integr Cancer Ther. 2015 Mar;14(2):184-95. doi: 10.1177/1534735414564425. Epub 2014 Dec 25.

論文名稱:Efficacy of antioxidants as a Complementary and Alternative Medicine (CAM) in combination with the chemotherapeutic agent doxorubicin.

作  者:Sheu MT, Jhan HJ, Hsieh CM, Wang CJ, Ho HO

出 版 年:2015

分  類:抗癌

論文結論:Ethanolic extract of Antrodia cinnamomea (EEAC) have the potential to be clinically applied to prevent cardiac toxicity and hand-foot syndrome (HFS) and enhance the anticancer efficiency of doxorubicin (Dox).

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論文出處:Food Chem Toxicol. 2015 Apr;78:33-41. doi: 10.1016/j.fct.2015.01.012. Epub 2015 Feb 2.

論文名稱:Antroquinonol from Antrodia Camphorata suppresses breast tumor migration/invasion through inhibiting ERK-AP-1- and AKT-NF-κB-dependent MMP-9 and epithelial-mesenchymal transition expressions.

作  者:Lee WT, Lee TH, Cheng CH, Chen KC, Chen YC, Lin CW

出 版 年:2015

分  類:抗癌

論文結論:Antroquinonol suppressed the migration and invasion of breast cancer MDA-MB-231 cells by suppressing ERK-AP-1- and AKT-NF-κB-dependent MMP-9 and EMT expressions. And inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced invasiveness by MCF7 cells.

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論文出處:Int J Mol Sci. 2016 Jun 7;17(6). pii: E893. doi: 10.3390/ijms17060893.

論文名稱:Cancer Stem Cells: The Potential Targets of Chinese Medicines and Their Active Compounds.

作  者:Hong M, Tan HY, Li S, Cheung F, Wang N, Nagamatsu T, Feng Y

出 版 年:2016

分  類:抗癌

論文結論:Use Chinese medicines (CMs) (such as Antrodia camphorate, berberine) and their active compounds may be a promising therapeutic strategy to eradicate cancer by targeting cancer stem cells (CSCs). The underlying molecular mechanisms and related signaling pathways involved in these processes were also discussed and concluded in this paper review.

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論文出處:Integr Cancer Ther. 2016 Nov 7. pii: 1534735416673907. [Epub ahead of print]

論文名稱:Coenzyme Q0 Enhances Ultraviolet B-Induced Apoptosis in Human Estrogen Receptor-Positive Breast (MCF-7) Cancer Cells.

作  者:Wang HM, Yang HL, Thiyagarajan V, Huang TH, Huang PJ, Chen SC, Liu JY, Hsu LS, Chang HW, Hseu YC

出 版 年:2017

分  類:抗癌

論文結論:Coenzyme Q0 (CoQ0; 2,3-dimethoxy-5-methyl-1,4-benzoquinone), a major active constituent of Antrodia camphorata, treatment inhibits the growth of breast cancer MCF-7 cells, and the cell viability was significantly decreased when the cells were pretreated with UVB irradiation.

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論文出處:Cancer Lett. 2016 Apr 10;373(2):174-84. doi: 10.1016/j.canlet.2015.11.046. Epub 2015 Dec 8.

論文名稱:Inhibition of growth, migration and invasion of human bladder cancer cells by antrocin, a sesquiterpene lactone isolated from Antrodia cinnamomea, and its molecular mechanisms.

作  者:Chiu KY, Wu CC, Chia CH, Hsu SL, Tzeng YM

出 版 年:2016

分  類:抗癌

論文結論:Antrocin, a sesquiterpene lactone isolated from Antrodia cinnamomea, induced both intrinsic and extrinsic apoptotic pathways in human bladder cancer 5637 cells, evidenced by increase of Fas, DR5, Bax expression and caspase-3, -8 and -9 activation.

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論文出處:Onco Targets Ther. 2016 Oct 27;9:6651-6661. eCollection 2016.

論文名稱:The medicinal fungus Antrodia cinnamomea regulates DNA repair and enhances the radiosensitivity of human esophageal cancer cells.

作  者:Liu YM, Liu YK, Wang LW, Huang YC, Huang PI, Tsai TH, Chen YJ

出 版 年:2016

分  類:抗癌

論文結論:Pretreatment with Antrodia cinnamomea mycelial fermentation broth (AC-MFB) decreased the survival of irradiated esophageal cancer cells, enhanced cell cycle arrest at the G2/M phase, the most radiosensitive phase.

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論文出處:J Ethnopharmacol. 2017 Jun 8. pii: S0378-8741(16)31038-8. doi: 10.1016/j.jep.2017.06.004. [Epub ahead of print]

論文名稱:Antrodia cinnamomea sensitizes radio-/chemo-therapy of cancer stem-like cells by modulating microRNA expression.

作  者:Su YK, Shih PH, Lee WH, Bamodu OA, Wu ATH, Huang CC, Tzeng YM, Hsiao M, Yeh CT, Lin CM

出 版 年:2017

分  類:抗癌

論文結論:Antrodia cinnamomea mycelium and its ethyl acetate extracts showed anti-proliferation effects against all types of CSCs, especially the lung, breast, and head and neck squamous cell carcinoma CSCs. An association between the CSC-inhibitory effect of Antrodia cinnamomea and significant downregulation of several microRNAs and cancer stemness expression levels in brain and breast CSCs. Higher CD133 expression is associated with poor prognosis in glioblastoma and breast cancer patients.

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論文出處:Molecules. 2017 May 6;22(5). pii: E747. doi: 10.3390/molecules22050747.

論文名稱:In Vitro Anticancer Activity and Structural Characterization of Ubiquinones from Antrodia cinnamomea Mycelium.

作  者:Yen IC, Lee SY, Lin KT, Lai FY, Kuo MT, Chang WL

出 版 年:2017

分  類:抗癌

論文結論:Two new ubiquinones, named antrocinnamone and 4-acetylantrocamol LT3, were isolated along with six known ubiquinones from Antrodia cinnamomea (Polyporaceae) mycelium, exhibited potential and selective cytotoxic activity against three human cancer cell lines. The suppression by 4-acetylantrocamol LT3 stopped the cell cycle at the beginning of the G2-M phase.

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