學術論文


Academic papers

抗發炎

論文出處:J Agric Food Chem. 2007 Jun 27;55(13):5007-12. Epub 2007 May 31.

論文名稱:Chemical characterization and anti-inflammatory effect of polysaccharides fractionated from submerge-cultured Antrodia camphorata mycelia.

作  者:Chen CC, Liu YW, Ker YB, Wu YY, Lai EY, Chyau CC, Hseu TH, Peng RY

出 版 年:2007

分  類:抗發炎

論文結論:

Five polysaccharide fractions (AC-1, AC-2, AC-3, AC-4, and AC-5) were obtained from Antrodia camphorata mycelia. 
In the evaluation of the DPPH* radical scavenging capability, fraction AC-1 and AC-2 polysaccharides showed the better capabilities. 
In testing with macrophage RAW264.7 cells, fraction AC-2 demonstrated a rather potent anti-inflammatory capability. 
And the lipopolysaccharide-induced NO production and the protein expression by the inducible nitric oxide synthase (iNOS) gene were inhibited by fraction AC-2 polysaccharide.

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論文出處:Acta Pharmacol Sin. 2007 Feb;28(2):258-67.

論文名稱:Modulation of inflammation-related genes of polysaccharides fractionated from mycelia of medicinal basidiomycete Antrodia camphorata.

作  者:Wu YY, Chen CC, Chyau CC, Chung SY, Liu YW

出 版 年:2007

分  類:抗發炎

論文結論:Alkaline extraction-isoelectric precipitated the polysaccharide fraction (AC-2) of Antrodia camphorata and had the ability to inhibit LPS-induced iNOS, IL-6, IL-10, MCP-5, and RANTES expression in mouse macrophages.

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論文出處:Biosci Biotechnol Biochem. 2007 Jan;71(1):23-30. Epub 2007 Jan 7.

論文名稱:Antihypertensive activities of a solid-state culture of Taiwanofungus camphoratus (Chang-chih) in spontaneously hypertensive rats.

作  者:Liu DZ, Liang YC, Lin SY, Lin YS, Wu WC, Hou WC, Su CH.

出 版 年:2007

分  類:抗發炎

論文結論:Methanol-soluble (MS) extracted of wild and solid-state cultures (SSC) of Antrodia camphorata exhibited angiotensin-converting enzyme (ACE) inhibitory activities and the antihypertensive effects. And was able to effectively lower the systolic blood pressure (SBP) and diastolic blood pressure (DBP) of spontaneously hypertensive rats.

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論文出處:J Ethnopharmacol. 2007 Mar 1;110(1):160-4. Epub 2006 Oct 4.

論文名稱:Protective effects of mycelia of Antrodia camphorata and Armillariella tabescens in submerged culture against ethanol-induced hepatic toxicity in rats.

作  者:Lu ZM, Tao WY, Zou XL, Fu HZ, Ao ZH

出 版 年:2007

分  類:抗發炎

論文結論:Administration of Antrodia camphorata markedly prevented ethanol-induced elevation of levels of serum AST, ALT, ALP, and bilirubin comparable with standard drug silymarin in rats.

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論文出處:J Nat Prod. 2008 Jul;71(7):1258-61. doi: 10.1021/np070634k. Epub 2008 Jun 4.

論文名稱:Maleimide and maleic anhydride derivatives from the mycelia of Antrodia cinnamomea and their nitric oxide inhibitory activities in macrophages.

作  者:Wu MD, Cheng MJ, Wang BC, Yech YJ, Lai JT, Kuo YH, Yuan GF, Chen IS.

出 版 年:2008

分  類:抗發炎

論文結論:Two new maleimide derivatives, antrocinnamomins A and B, and two new maleic anhydride derivatives, antrocinnamomins C and D, with three known compounds, 3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]furan-2,5-dione, 3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]-1H-pyrrole-2,5-dione, and 3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]-1H-pyrrol-1-ol-2,5-dione, were isolated from mycelium of Antrodia cinnamomea. Antrocinnamomins A displayed significant inhibitory effect on nitric oxide (NO) production.

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論文出處:J Ethnopharmacol. 2008 Nov 20;120(2):196-203. doi: 10.1016/j.jep.2008.08.011. Epub 2008 Aug 19.

論文名稱:Immunomodulatory effect of Antrodia camphorata mycelia and culture filtrate.

作  者:Kuo MC, Chang CY, Cheng TL, Wu MJ

出 版 年:2008

分  類:抗發炎

論文結論:The mycelia fraction (Fr. M II) and culture filtrate fractions (Fr. E II and Fr. E III) were water extracts from Antrodia camphorata (AC), can modulate innate immunity and may serve as an adjuvant for tumor treatment.

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論文出處:J Agric Food Chem. 2008 Aug 27;56(16):7017-22. doi: 10.1021/jf801171x. Epub 2008 Jul 19.

論文名稱:Anti-inflammatory activities of new succinic and maleic derivatives from the fruiting body of Antrodia camphorata.

作  者:Chien SC, Chen ML, Kuo HT, Tsai YC, Lin BF, Kuo YH

出 版 年:2008

分  類:抗發炎

論文結論:New compound, trans-3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]pyrrolidine-2,5-dione, increased spontaneous TNF-alpha secretion from unstimulated RAW264.7 cells but suppressed IL-6 production in LPS-stimulated cells. New compounds, cis-3-(4-hydroxyphenyl)-4-isobutyldihydrofuran-2,5-dione, 3-(4-hydroxyphenyl)-4-isobutyl-1H-pyrrole-2,5-dione, and dimethyl 2-(4-hydroxyphenyl)-3-isobutylmaleate, also suppressed IL-6 production, have an anti-inflammatory effect on macrophage-mediated responses.

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論文出處:J Ethnopharmacol. 2008 Jul 23;118(2):237-45. doi: 10.1016/j.jep.2008.04.004. Epub 2008 Apr 12.

論文名稱:Antioxidant activity of Antrodia camphorata on free radical-induced endothelial cell damage.

作  者:Hseu YC, Chen SC, Yech YJ, Wang L, Yang HL

出 版 年:2008

分  類:抗發炎

論文結論:Antrodia camphorata possesses antioxidant properties and improves endothelial function, further offering effective protection from atherosclerosis.

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論文出處:Int Immunopharmacol. 2008 Mar;8(3):458-67. doi: 10.1016/j.intimp.2007.11.008. Epub 2007 Dec 28.

論文名稱:Polysaccharides from Antrodia camphorata mycelia extracts possess immunomodulatory activity and inhibits infection of Schistosoma mansoni.

作  者:hen YJ, Cheng PC, Lin CN, Liao HF, Chen YY, Chen CC, Lee KM

出 版 年:2008

分  類:抗發炎

論文結論:Antrodia camphorata polysaccharides (AC-PS) appears to modulate the immune system of mice and has potential for preventing Schistosoma mansoni infection.

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論文出處:Toxicol Appl Pharmacol. 2008 Mar 1;227(2):291-8. Epub 2007 Nov 7.

論文名稱:In vivo immunomodulatory effects of Antrodia camphorata polysaccharides in a T1/T2 doubly transgenic mouse model for inhibiting infection of Schistosoma mansoni.

作  者:Cheng PC, Hsu CY, Chen CC, Lee KM.

出 版 年:2008

分  類:抗發炎

論文結論:The polysaccharides derived from Antrodia camphorata (AC-PS) appears to influence the immune system of mice into developing Th1 responses and have potential for preventing infection with Schistosoma mansoni.

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論文出處:Eur J Immunol. 2009 Sep;39(9):2482-91. doi: 10.1002/eji.200839039.

論文名稱:A triterpenoid methyl antcinate K isolated from Antrodia cinnamomea promotes dendritic cell activation and Th2 differentiation.

作  者:Yu YL, Chen IH, Shen KY, Huang RY, Wang WR, Chou CJ, Chang TT, Chu CL.

出 版 年:2009

分  類:抗發炎

論文結論:Methyl antcinate K (me-AntK), A triterpenoid isolated from Antrodia cinnamomea,  promote the ability of Dendritic cells (DC) to prime Th2 responses. And enhance immune responses and modulate DC function in immunotherapy.

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論文出處:J Ethnopharmacol. 2009 Jun 25;123(3):407-12. doi: 10.1016/j.jep.2009.03.034. Epub 2009 Mar 31.

論文名稱:Anti-angiogenic effects and mechanisms of polysaccharides from Antrodia cinnamomea with different molecular weights.

作  者:Yang CM, Zhou YJ, Wang RJ, Hu ML.

出 版 年:2009

分  類:抗發炎

論文結論:Polysaccharides from mycelia of Antrodia cinnamomea (PMAC) are anti-angiogenic in vitro and ex vivo, and the effects are likely through immunomodulation.

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論文出處:Phytother Res. 2009 Apr;23(4):582-4. doi: 10.1002/ptr.2657.

論文名稱:Inhibitory effects of antrodins A-E from Antrodia cinnamomea and their metabolites on hepatitis C virus protease.

作  者:Phuong do T, Ma CM, Hattori M, Jin JS.

出 版 年:2009

分  類:抗發炎

論文結論:Antrodin A, a succinic acid constituents isolated from Antrodia cinnamomea, have inhibitory activity on hepatitis C virus (HCV) protease. And was also detected as an in vivo metabolite of the major constituent antrodin C.

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論文出處:Int Heart J. 2009 Mar;50(2):207-20.

論文名稱:A novel inhibitory effect of Antrodia camphorata extract on vascular smooth muscle cell migration and neointima formation in mice.

作  者:Li YH, Chung HC, Liu SL, Chao TH, Chen JC

出 版 年:2009

分  類:抗發炎

論文結論:Antrodia camphorata (AC)  is an effective inhibitor of platelet-derived growth factor (PDGF)-induced rat aortic smooth muscle cell (RASMC) proliferation and migration. AC treatment reduced neointima formation in this mouse carotid ligation model.

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論文出處:Planta Med. 2009 Apr;75(5):512-6. doi: 10.1055/s-0029-1185305. Epub 2009 Feb 2.

論文名稱:New constituents with iNOS inhibitory activity from mycelium of Antrodia camphorata.

作  者:Yang SS, Wang GJ, Wang SY, Lin YY, Kuo YH, Lee TH.

出 版 年:2009

分  類:抗發炎

論文結論:

Five compounds from mycelium of Antrodia camphorata were isolated by the guidance of an inducible nitric oxide synthase (iNOS) inhibitory assay analysis. 
1. 2,4-dimethoxy-6-methylbenzene-1,3-diol and antrodin D significantly inhibited NO production without any cytotoxicity. 
2. Antroquinonol B and 4-acetyl-antroquinonol B possessed greater effects on NO inhibition, but displayed cytotoxicity at considerably higher concentrations. 
3. 2,3-(methylenedioxy)-6-methylbenzene-1,4-diol showed the lowest cell viability in treated cells.

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