學術論文


Academic papers

抗發炎

論文出處:J Agric Food Chem. 2011 Apr 27;59(8):4248-54. doi: 10.1021/jf104561h. Epub 2011 Mar 14.

論文名稱:Effects of Antrodia camphorata on alcohol clearance and antifibrosis in livers of rats continuously fed alcohol.

作  者:Wu MT, Tzang BS, Chang YY, Chiu CH, Kang WY, Huang CH, Chen YC.

出 版 年:2011

分  類:抗發炎

論文結論:Antrodia camphorata could lower liver damage in rats chronically fed alcohol.

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論文出處:ree Radic Biol Med. 2011 Jun 1;50(11):1503-16. doi: 10.1016/j.freeradbiomed.2011.02.029. Epub 2011 Mar 2.

論文名稱:Antroquinonol reduces oxidative stress by enhancing the Nrf2 signaling pathway and inhibits inflammation and sclerosis in focal segmental glomerulosclerosis mice.

作  者:Tsai PY, Ka SM, Chao TK, Chang JM, Lin SH, Li CY, Kuo MT, Chen P, Chen A.

出 版 年:2011

分  類:抗發炎

論文結論:Antroquinonol is an active component by Antrodia camphorata, that might a therapeutic agent for focal segmental glomerulosclerosis (FSGS), acting by boosting Nrf2 activation and suppressing NF-κB-dependent inflammatory and TGF-β1-mediated fibrosis pathways in the kidney in a mice model.

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論文出處:Nat Prod Res. 2011 Apr;25(7):684-95. doi: 10.1080/14786410802525487. Epub 2010 Jul 9.

論文名稱:Further studies on the hepatoprotective effect of Antrodia camphorata in submerged culture on ethanol-induced acute liver injury in rats.

作  者:Lu ZM, Tao WY, Xu HY, Ao ZH, Zhang XM, Xu ZH.

出 版 年:2011

分  類:抗發炎

論文結論:The ethanolic extract (Fr-I) of Antrodia camphorata was the most effective in the prevention of ethanol-induced acute liver injury and free radical generation in rats.

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論文出處:Phytomedicine. 2012 Mar 15;19(5):424-35. doi: 10.1016/j.phymed.2011.11.003. Epub 2012 Jan 30.

論文名稱:Methanol extract of Antrodia cinnamomea mycelia induces phenotypic and functional differentiation of HL60 into monocyte-like cells via an ERK/CEBP-β signaling pathway.

作  者:Wen CL, Teng CL, Chiang CH, Chang CC, Hwang WL, Kuo CL, Hsu SL.

出 版 年:2012

分  類:抗發炎

論文結論:Methanol extract of liquid cultured mycelia of Antrodia cinnamomea (MEMAC) inhibited proliferation and induced G1-phase cell cycle arrest in HL60 cells, and their monocytic differentiation is via the activating ERK signaling pathway, and downstream upregulating the transcription factor C/EBPβ and differentiation marker CD14 gene.

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論文出處:J Tradit Complement Med. 2012 Apr;2(2):84-95.

論文名稱:Recent progress of research on medicinal mushrooms, foods, and other herbal products used in traditional Chinese medicine.

作  者:Lee KH, Morris-Natschke SL, Yang X, Huang R, Zhou T, Wu SF, Shi Q, Itokawa H

出 版 年:2012

分  類:抗發炎

論文結論:This review focus on the active constituents of the herbs (Taiwanofungus camphoratus) and their bioactivities, with emphasis on the most recent progress in research for the period of 2003 to 2011.

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論文出處:Am J Chin Med. 2012;40(5):953-65. doi: 10.1142/S0192415X1250070X.

論文名稱:Inhibition of Na(+)/K(+) -ATPase by antcins, unique steroid-like compounds in Antrodia camphorate.

作  者:Chung TY, Li FY, Chang CI, Jinn TR, Tzen JT.

出 版 年:2012

分  類:抗發炎

論文結論:Five steroid compounds, antcin A, B, C, H, and K were isolated from Antrodia camphorata, and all inhibited Na(+)/K(+) -ATPase. Antcin A exhibited significantly higher inhibitory potency than the other four antcins, is a bi-functional compound that exerts anti-inflammatory effects and that enhances blood circulation.

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論文出處:Int J Med Mushrooms. 2012;14(3):241-56.

論文名稱:Review of biological and pharmacological activities of the endemic Taiwanese bitter medicinal mushroom, Antrodia camphorata (M. Zang et C. H. Su) Sh. H. Wu et al. (higher Basidiomycetes).

作  者:Yue PY, Wong YY, Chan TY, Law CK, Tsoi YK, Leung KS

出 版 年:2012

分  類:抗發炎

論文結論:Summarizes the latest published results from Antrodia camphorata research, focusing on the biological and pharmacological activities of the crude extract compounds (Including polysaccharides, terpenoids, steroids, lignans, benzoquinone derivatives, benzenoids, and maleic and succinic acid derivatives) and their functions  (such as anti-hypertensive, anti-hyperlipidemic, anti-inflammatory, anti-oxidant, anti-tumor, and immuno-modulatory activities).

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論文出處:Nutrition. 2012 Sep;28(9):942-9. doi: 10.1016/j.nut.2012.01.006. Epub 2012 Apr 26.

論文名稱:Polysaccharides from extracts of Antrodia camphorata mycelia and fruiting bodies modulate inflammatory mediator expression in mice with polymicrobial sepsis.

作  者:Meng LM, Pai MH, Liu JJ, Yeh SL.

出 版 年:2012

分  類:抗發炎

論文結論:The polysaccharides contained within Antrodia camphorata (AC-PSs) from mycelia or fruiting bodies decreased the inflammatory mediator expressions at the location of injury and in the circulation, especially in the late stage of sepsis. From fruiting bodies seemed to be more effective in decreasing the inflammatory response than those from mycelia.

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論文出處:J Pharm Biomed Anal. 2012 Jan 25;58:182-92. doi: 10.1016/j.jpba.2011.09.007. Epub 2011 Sep 16.

論文名稱:Chemical profiling of the cytotoxic triterpenoid-concentrating fraction and characterization of ergostane stereo-isomer ingredients from Antrodia camphorata.

作  者:Du YC, Wu TY, Chang FR, Lin WY, Hsu YM, Cheng FT, Lu CY, Yen MH, Tsui YT, Chen HL, Hou MF, Lu MC, Wu YC.

出 版 年:2012

分  類:抗發炎

論文結論:A method for concentrating the antiproliferative active triterpenoid-rich fraction (FEA), from ethanolic extract of AC (EEAC). Eight ergostanes and two lanostanes were characterised by high-performance liquid chromatography-photodiode array detection/mass spectrometry (HPLC-PDA/MS).Eight ergostanes and their pair mixture forms (antcin K, antcin C, zhankuic acid C, and zhankuic acid A) were subjected to anti-proliferative assay against three human leukemia cell lines (CCRF-CEM, Molt 4 and HL 60).

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論文出處:Arthritis Rheum. 2012 Jan;64(1):232-42. doi: 10.1002/art.33328.

論文名稱:Antroquinonol differentially modulates T cell activity and reduces interleukin-18 production, but enhances Nrf2 activation, in murine accelerated severe lupus nephritis.
 

作  者:Tsai PY, Ka SM, Chang JM, Lai JH, Dai MS, Jheng HL, Kuo MT, Chen P, Chen A.

出 版 年:2012

分  類:抗發炎

論文結論:Antroquinonol, a purified compound of Antrodia camphorata, may have therapeutic potential for the early treatment of accelerated severe lupus nephritis (ASLN) via its differential regulation of T cell function and lowering of IL-18 production, but also via the promotion of Nrf2 activation.

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論文出處:Molecules. 2013 Dec 19;19(1):22-40. doi: 10.3390/molecules19010022.

論文名稱:Physicochemical characteristics and anti-inflammatory activities of antrodan, a novel glycoprotein isolated from Antrodia cinnamomea mycelia.

作  者:Chiu CH, Peng CC, Ker YB, Chen CC, Lee A, Chang WL, Chyau CC, Peng RY

出 版 年:2013

分  類:抗發炎

論文結論:Antrodan, a novel polysaccharide obtained from mycelia of Antrodia cinnamomea, was characterized as a glycoprotein. It showed potent suppressing effect on the lipopolysaccharide-induced inflammatory responses in RAW 264.7 cell line. And reduced the nitrogen oxide production.

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論文出處:J Agric Food Chem. 2013 Sep 11;61(36):8556-64. doi: 10.1021/jf402849b. Epub 2013 Aug 30.

論文名稱:Establishment of the metabolite profile for an Antrodia cinnamomea health food product and investigation of its chemoprevention activity.

作  者:Wang HC, Chu FH, Chien SC, Liao JW, Hsieh HW, Li WH, Lin CC, Shaw JF, Kuo YH, Wang SY.

出 版 年:2013

分  類:抗發炎

論文結論:4-Acetylantroquinonol B obtained from ethanolic extract ofAntrodia cinnamomea mycelium (EMAC), was able to not only inhibit LPS-induced nitric oxide formation in macrophages but also protect against ethanol-induced oxidative stress in liver cells. And significantly reduced liver inflammation and serum oxidative stress in vivo.

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論文出處:Phytomedicine. 2013 Jul 15;20(10):874-82. doi: 10.1016/j.phymed.2013.03.008. Epub 2013 Apr 20.

論文名稱:Elucidating the inhibitory mechanisms of the ethanolic extract of the fruiting body of the mushroom Antrodia cinnamomea on the proliferation and migration of murine leukemia WEHI-3 cells and their tumorigenicity in a BALB/c allograft tumor model.

作  者:Liu FC, Lai MT, Chen YY, Lin WH, Chang SJ, Sheu MJ, Wu CH.

出 版 年:2013

分  類:抗發炎

論文結論:Ethanolic extract of Antrodia cinnamomea (EEAC) inhibited the proliferation and reduced the migration of WEHI-3 cells, resulting in the accumulation of cell in G0/G1 and G2/M phases in vitro. And the ability of EEAC to reduced infiltration of WEHI-3 cells into the liver and spleen in vivo.

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論文出處:Chem Biodivers. 2013 Mar;10(3):434-41. doi: 10.1002/cbdv.201200258.

論文名稱:Inhibitory effects of maleimide derivatives from the mycelia of the fungus Antrodia cinnamomea BCRC 36799 on nitric oxide production in lipopolysaccharide (LPS)-activated RAW264.7 macrophages.

作  者:Wu MD, Cheng MJ, Yech YJ, Yuan GF, Chen JJ.

出 版 年:2013

分  類:抗發炎

論文結論:Four new maleimide derivatives, antrocinnamomins E-H, with (3S,4R)-1-hydroxy-3-(4-hydroxyphenyl)-4-(2-methylpropyl)pyrrolidine-2,5-dione and ergosterol were isolated from the mycelia of Antrodia cinnamomea BCRC 36799. Antrocinnamomins F and H showed stronger inhibition of NO production.

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論文出處:Appl Microbiol Biotechnol. 2013 Dec;97(23):9955-67. doi: 10.1007/s00253-013-5214-1. Epub 2013 Sep 24.

論文名稱:Antrodia camphorata-fermented product cultured in deep ocean water has more liver protection against thioacetamide-induced fibrosis.

作  者:Wang LC, Kuo IU, Tsai TY, Lee CL.

出 版 年:2013

分  類:抗發炎

論文結論:Antrodia camphorata-fermented product cultured in Deep ocean water (DOW-AC) prevented from thioacetamide (TAA)-induced weight loss and had more effect on inhibiting lipid peroxidation, reactive oxygen species, iNOS, and TNF-α expression. DOW-AC increased the production of Antrodia camphorata-fermented functional metabolites (triterpenoids, polysaccharides, flavonoids, and polyphenols) and had more potent effect on protection against TAA-induced liver damage and fibrosis.

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