學術論文


Academic papers

抗發炎

論文出處:Food Chem. 2013 Dec 1;141(3):3020-7. doi: 10.1016/j.foodchem.2013.03.061. Epub 2013 Apr 6.

論文名稱:Hepatoprotective effects of eburicoic acid and dehydroeburicoic acid from Antrodia camphorata in a mouse model of acute hepatic injury.

作  者:Huang GJ, Deng JS, Huang SS, Lee CY, Hou WC, Wang SY, Sung PJ, Kuo YH.

出 版 年:2013

分  類:抗發炎

論文結論:Eburicoic acid (TR1) and dehydroeburicoic acid (TR2) protect the liver from CCl4-induced hepatic damage via antioxidant and anti-inflammatory mechanisms.

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論文出處:Evid Based Complement Alternat Med. 2013;2013:914524. doi: 10.1155/2013/914524. Epub 2013 May 30.

論文名稱:Ethanol Extract of Antrodia camphorata Grown on Germinated Brown Rice Suppresses Inflammatory Responses in Mice with Acute DSS-Induced Colitis.

作  者:Park DK, Park HJ.

出 版 年:2013

分  類:抗發炎

論文結論:The anti-inflammatory activity of Antrodia camphorata (AC) grown on germinated brown rice (CBR) is a promising, potential agent for preventing acute colitis through the inhibition of NF-κB signaling and its upstream signaling molecules, including MAPKs. 

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論文出處:Free Radic Biol Med. 2013 Aug;61:285-97. doi: 10.1016/j.freeradbiomed.2013.03.024. Epub 2013 Apr 6.

論文名稱:Antroquinonol mitigates an accelerated and progressive IgA nephropathy model in mice by activating the Nrf2 pathway and inhibiting T cells and NLRP3 inflammasome.

作  者:Yang SM, Ka SM, Hua KF, Wu TH, Chuang YP, Lin YW, Yang FL, Wu SH, Yang SS, Lin SH, Chang JM, Chen A.

出 版 年:2013

分  類:抗發炎

論文結論:Antroquinonol administration substantially impeded the development of severe renal lesions (glomerular proliferation, crescents, sclerosis, and periglomerular interstitial inflammation), in mice with induced accelerated and progressive IgA nephropathy (AcP-IgAN).

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論文出處:J Nat Prod. 2013 Apr 26;76(4):489-94. doi: 10.1021/np300443p. Epub 2013 Mar 21.

論文名稱:Anti-inflammatory lanostanoids and lactone derivatives from Antrodia camphorata.

作  者:Liaw CC, Chen YC, Huang GJ, Tsai YC, Chien SC, Wu JH, Wang SY, Chao LK, Sung PJ, Huang HC, Kuo YH.

出 版 年:2013

分  類:抗發炎

論文結論:Four new lanostanoids and two new lactone derivatives, with four known compounds, were characterized from Antrodia camphorata. Ethyl lucidenate A, 15-O-acetylganolucidate A, 11α-hydroxy-3,7-dioxolanost-8,24(E)-dien-26- oic acid, 3,7,11-trioxo-5α-lanosta-8,24(E)-dien-26-oic acid, methyl 3,7,11,12,15,23-hexaoxo-5α-lanost-8-en-26-oate, and ethyl 3,7,11,12,15,23-hexaoxo-5α-lanost-8-en-26-oate significantly suppressed the NO concentration in LPS-treated RAW 264.7 cells.

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論文出處:J Agric Food Chem. 2013 May 29;61(21):5064-71. doi: 10.1021/jf303820k. Epub 2013 May 16.

論文名稱:Analgesic and anti-inflammatory bioactivities of eburicoic acid and dehydroeburicoic acid isolated from Antrodia camphorata on the inflammatory mediator expression in mice.

作  者:Deng JS, Huang SS, Lin TH, Lee MM, Kuo CC, Sung PJ, Hou WC, Huang GJ, Kuo YH.

出 版 年:2013

分  類:抗發炎

論文結論:The anti-inflammatory mechanisms of Eburicoic acid (TR1) and dehydroeburicoic acid (TR2) might be related to the decrease of inflammatory cytokines and an increase of antioxidant enzyme activity.

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論文出處:Int J Mol Sci. 2013 Feb 26;14(3):4629-39. doi: 10.3390/ijms14034629.

論文名稱:New Anti-Inflammatory Aromatic Components from Antrodia camphorata.

作  者:Chen YC, Chiu HL, Chao CY, Lin WH, Chao LK, Huang GJ, Kuo YH.

出 版 年:2013

分  類:抗發炎

論文結論:Five benzenoids were isolated from Antrodia camphorata. That potently inhibited LPS (lipopolysaccharide)-induced nitric oxide (NO) production.

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論文出處:China journal of Chinese materia medica. 2014 May;39(9):1670-4.

論文名稱:[Effect of Antrodia cinnamomea on gene expression related to aortal endothelial injury in rats with hyperlipidemia].
[Article in Chinese]

作  者:Qi J, Tao Y, Zhang J, Fu J.

出 版 年:2014

分  類:抗發炎

論文結論:Antrodia cinnamomea can alleviate endothelial lipid injury by inhibiting the expressions of LOX-1, P38MAPK and NF-kappaB in aorta and better protect aortal endothelial cells from oxidative lipid injury.

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論文出處:J Ethnopharmacol. 2014 Aug 8;155(1):154-64. doi: 10.1016/j.jep.2014.04.053. Epub 2014 May 20.

論文名稱:The medicinal fungus Antrodia cinnamomea suppresses inflammation by inhibiting the NLRP3 inflammasome.

作  者:Huang TT, Wu SP, Chong KY, Ojcius DM, Ko YF, Wu YH, Wu CY, Lu CC, Martel J, Young JD, Lai HC

出 版 年:2014

分  類:抗發炎

論文結論:Antrodia cinnamomea ethanol extract (ACEE) suppresses the secretion of IL-1β and IL-18 associated with inhibition of the NLRP3 inflammasome in macrophages, have therapeutic potential for the treatment of inflammatory diseases.

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論文出處:Food Chem Toxicol. 2014 Jul;69:150-62. doi: 10.1016/j.fct.2014.04.006. Epub 2014 Apr 18.

論文名稱:Antrodia cinnamomea profoundly exalted the reversion of activated hepatic stellate cells by the alteration of cellular proteins.

作  者:Chen YR, Chang KT, Tsai MJ, Lee CH, Huang KJ, Cheng H, Ho YP, Chen JC, Yang HH, Weng CF

出 版 年:2014

分  類:抗發炎

論文結論:Antrodia cinnamomea mycelial extract (ACME) could improve liver morphology and histological changes including collagen formation and GPT activity in the liver of thioacetamide (TAA)-injured rats.

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論文出處:Int J Radiat Biol. 2014 Oct;90(10):841-52. doi: 10.3109/09553002.2014.911989. Epub 2014 Aug 11.

論文名稱:Radioprotective effects of Antrodia cinnamomea are enhanced on immune cells and inhibited on cancer cells.

作  者:Cheng PC, Huang CC, Chiang PF, Lin CN, Li LL, Lee TW, Lin B, Chen IC, Chang KW, Fan CK, Luo TY.

出 版 年:2014

分  類:抗發炎

論文結論:Antrodia cinnamomea (AC) may inhibit important immunoregulatory signaling which could be vital in the avoidance of an over-activated cytotoxic and inflammatory response of the immune system caused by radiation-induced tissue damage. AC does not provide a radioprotective effect to tumor cells but instead enhances radiation-induced inflammation and cytotoxicity in cancer.

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論文出處:PLoS One. 2014 Apr 1;9(4):e93191. doi: 10.1371/journal.pone.0093191. eCollection 2014.

論文名稱:Hepatoprotective bioactivity of the glycoprotein, antrodan, isolated from Antrodia cinnamomea mycelia.

作  者:Ker YB, Peng CC, Chang WL, Chyau CC, Peng RY

出 版 年:2014

分  類:抗發炎

論文結論:Antrodan, a polysaccharide isolated from mycelia of Antrodia cinnamomea, can potentially ameliorate liver damage in vivo by suppressing oxidative stress induced by LPS.

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論文出處:Biochem Pharmacol. 2014 Sep 15;91(2):217-30. doi: 10.1016/j.bcp.2014.06.026. Epub 2014 Jul 27.

論文名稱:Zhankuic acid A as a novel JAK2 inhibitor for the treatment of concanavalin A-induced hepatitis.

作  者:Chen YF, Wang SH, Chang SJ, Shiau AL, Her LS, Shieh GS, Chen CF, Chang CC, Su YC, Wu CL, Wu TS

出 版 年:2014

分  類:抗發炎

論文結論:Zhankuic acid A (ZAA), a major pharmacologically active compound, can inhibit JAK2 phosphorylation and protect against liver injury during acute hepatitis in mice.

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論文出處:J Immunol. 2014 Mar 15;192(6):2778-86. doi: 10.4049/jimmunol.1301931. Epub 2014 Feb 14.

論文名稱:Zhankuic acid A isolated from Taiwanofungus camphoratus is a novel selective TLR4/MD-2 antagonist with anti-inflammatory properties.

作  者:Chen YF, Shiau AL, Wang SH, Yang JS, Chang SJ, Wu CL, Wu TS.

出 版 年:2014

分  類:抗發炎

論文結論:Zhankuic acid A (ZAA), a major pharmacologically active compound of Taiwanofungus camphoratus, which can compete with LPS for binding to MD-2 as a TLR4/MD-2 antagonist, may be a potential therapeutic agent for gram-negative bacterial infections.

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論文出處:ScientificWorldJournal. 2014;2014:745802. doi: 10.1155/2014/745802. Epub 2014 Oct 14.

論文名稱:Effect of Antrodia camphorata on inflammatory arterial thrombosis-mediated platelet activation: the pivotal role of protein kinase C.

作  者:Lu WJ, Lin SC, Lan CC, Lee TY, Hsia CH, Huang YK, Lee HC, Sheu JR

出 版 年:2014

分  類:抗發炎

論文結論:Antrodia camphorata may inhibit platelet activation by inhibiting of Ca2+ and PKC cascade and the Akt pathway. That may be a potential therapeutic agent for preventing or treating thromboembolic disorders.

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論文出處:Phytomedicine. 2014 Oct 15;21(12):1708-16. doi: 10.1016/j.phymed.2014.08.011. Epub 2014 Sep 16.

論文名稱:Comparison of solid-state-cultured and wood-cultured Antrodia camphorata in anti-inflammatory effects using NF-κB/luciferase inducible transgenic mice.

作  者:Tung YT, Tsai TC, Kuo YH, Yen CC, Sun JY, Chang WH, Chen HL, Chen CM

出 版 年:2014

分  類:抗發炎

論文結論:Methanolic extracts both of solid-state-cultured AC (S-AC) and wood-cultured AC (W-AC) have excellent anti-inflammatory activities.

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