學術論文


Academic papers

抗發炎

論文出處:嘉南藥理大學 生物科技系

論文名稱:牛樟芝化妝品原料開發之研究

作  者:吳慶煌

出 版 年:2015

分  類:抗發炎

論文結論:牛樟芝菌膜和牛樟芝子實體經75% EtOH萃取,在沙門氏菌安全性試驗皆無致突變性。以脂多糖 (Lipopolysaccharide, LPS) 剌激巨噬細胞RAW264.7後,給予75% EtOH萃取牛樟芝子實體,一氧化氮濃度明顯下降。且牛樟芝菌膜和牛樟芝子實體經75% EtOH萃取皆具有良好的抗自由基能力。具有成為優質化妝品原料的潛力

『原文』超連結

『全文下載』超連結


論文出處:Nat Prod Res. 2017 Aug 2:1-4. doi: 10.1080/14786419.2017.1320785. [Epub ahead of print]

論文名稱:Constituents from solid-cultured Antrodia camphorata.

作  者:Tong ZB, Cui XH, Wang J, Zhang CL, Zhang YY, Ren ZJ

出 版 年:2017

分  類:抗癌

論文結論:A new naphthalenecarboxaldehyde, named as 1-Naphthalenecarboxaldehyde,3,4,4a,5,6,7,8,8a-octahydro-2-(hydroxymethyl)-5,5,8a-trimethyl. With seven other known compounds of nerolidol, cadinol, herbarulide, 3β-Hydroxy-5a,8a-epidioxyergosta-6,22-diene, ergosta-7,22-diene-3,6-dione, 2,3-dimethoxy-5-methyl-p-benzoquinone and β-sitosterol were obtained from Antrodia camphorata. 2,3-dimethoxy-5-methyl-p-benzoquinone and β-sitosterol exhibited significant toxicity to hepG2 cell.

『原文』超連結

『全文下載』超連結


論文出處:Cytokine. 2018 Mar 29;108:136-144. doi: 10.1016/j.cyto.2018.03.035. [Epub ahead of print]

論文名稱:Analogous corticosteroids, 9A and EK100, derived from solid-state-cultured mycelium of Antrodia camphorata inhibit proinflammatory cytokine expression in macrophages.

作  者:Kao ST, Kuo YH, Wang SD, Hong HJ, Lin LJ

出 版 年:2018

分  類:抗發炎

論文結論:The pharmacologically active compounds in a crude solid-state-cultured mycelium of Antrodia camphorata (SCMAC) extract exert synergistic effects on multiple targets to relieve asthma symptoms.

『原文』超連結

『全文下載』超連結


論文出處:美和科技大學 生技科技系健康產業碩士班

論文名稱:牛樟芝成份分析、生物活性及其 對人類肝癌細胞Hep G2抑制之研究

作  者:温峰昌

出 版 年:2017

分  類:抗癌

論文結論:皿培牛樟芝確可得到相當量的三萜類;多醣體含量是自製培養基之紅白牛樟均高於市售培養基;總多酚類含量與抗氧化力為皿培牛樟芝高於椴木白牛樟。另外研究發現皿培培養基添加重要元素P1可增加牛樟芝指標成份如Antcin A、B、H、DeSA和DeEA等含量。另外抗肝癌細胞試驗顯示牛樟芝有不錯抑癌效果。

『原文』超連結

『全文下載』超連結


論文出處:實踐大學 食品營養與保健生技學系

論文名稱:樟芝對於倉鼠肝臟蛋白質體的影響

作  者:林秀娟

出 版 年:2015

分  類:抗發炎

論文結論:餵飼倉鼠樟芝,能降低血清三酸甘油酯及總膽固醇濃度、增加糞便膽酸排除。樟芝降低發炎標記物膜聯蛋白(annexin A3, ANXA3)、促發炎蛋白環氧化酶(cyclooxygenase-2, COX-2)和載脂蛋白(apolipotein E, apoE)的表現。此外,樟芝增加參與糖解的甘油-3-磷酸脫氫酶(glycerol-3-phosphate dehydrogenase, GPDH)和參與β-oxidation的hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase的α-subunit (HADHA) 的表現

『原文』超連結

『全文下載』超連結


論文出處:J Dermatol Sci. 2018 Nov;92(2):188-196. doi: 10.1016/j.jdermsci.2018.09.002. Epub 2018 Sep 7.

論文名稱:The atopic dermatitis-like lesion and the associated MRSA infection and barrier dysfunction can be alleviated by 2,4-dimethoxy-6-methylbenzene-1,3-diol from Antrodia camphorata.

作  者:Yang SC, Huang TH, Chiu CH, Chou WL, Alalaiwe A, Yeh YC, Su KW, Fang JY.

出 版 年:2018

分  類:抗發炎

論文結論:

2,4-Dimethoxy-6-methylbenzene-1,3-diol (DMD), is a benzenoid isolated from Antrodia camphorata, exhibited a comparative minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) against methicillin-resistant S. aureus (MRSA) with nalidixic acid, a conventional antibiotic. Demonstrated an advanced concept of Atopic dermatitis (AD, an inflammatory skin disease) treatment by combined barrier repair and bacterial eradication with a sole agent for ameliorating the overall complications.

『原文』超連結

『全文下載』超連結


論文出處:J Nat Prod. 2017 Sep 12. doi: 10.1021/acs.jnatprod.7b00223. [Epub ahead of print]

論文名稱:Meroterpenoids from a Medicinal Fungus Antrodia cinnamomea.

作  者:Chen MC, Cho TY, Kuo YH, Lee TH

出 版 年:2017

分  類:抗癌

論文結論:Twenty antroquinonols isolated from Antrodia cinnamomea IFS006. Antroquinonol A exhibited the most potent activity in human A549 and PC-3 cancer cell lines, with GI50 values of 5.7 ± 0.2 and 13.5 ± 0.2 μM, respectively. Antroquinonols V (9) and W (10) also showed growth inhibitory activity against A549 cells with GI50 values of 8.2 ± 0.8 and 7.1 ± 2.1 μM, respectively.

『原文』超連結

『全文下載』超連結


論文出處:國立清華大學 生物資訊與結構生物研究所

論文名稱:藉由蛋白質體學分析牛樟芝對肝癌的醫療效益

作  者:林芷君

出 版 年:2017

分  類:抗癌

論文結論:

『原文』超連結

『全文下載』超連結


論文出處:屏東科技大學 食品科學系所

論文名稱:牛樟芝多醣體(ACP-1)對於小鼠巨噬細胞NF-kappaB發炎信號反應之調節

作  者:蘇俊仁

出 版 年:2015

分  類:抗發炎

論文結論:牛樟芝菌絲體固態發酵產物中分離純化出一種多醣體物質(ACP-1)能抑制小鼠巨噬細胞RAW264.7藉由脂多醣(LPS)所引發之NF-κB 訊號傳遞,並且能抑制如RANTES, IFN-β1, lncRNA-ch1a, 以及lncRNA-ch1b; chr2 等脂多醣所誘發的特定發炎作用相關之基因,進而減少與其相關之發炎反應。

『原文』超連結

『全文下載』超連結


論文出處:Polymers (Basel). 2017 Jun 16;9(6). pii: E228. doi: 10.3390/polym9060228.

論文名稱:A Novel Heterogalactan from Antrodia camphorata and Anti-Angiogenic Activity of Its Sulfated Derivative.

作  者:Liu Y, Ding Y, Ye M, Zhu T, Tian D, Ding K.

出 版 年:2017

分  類:抗發炎

論文結論:

A heterogalactan, named ACW0, was extracted from Antrodia camphorata and purified by anion exchange and gel permeation chromatography. A sulfated polysaccharide, ACW0-Sul was achieved by the chlorosulfonic acid-pyridine method. ACW0-Sul could be a potent candidate for anti-angiogenic agent development. human microvascular endothelial cells (HMEC-1) "1. ACW0-Sul could disrupt tube formation and migration as well as cell growth of human microvascular endothelial cells (HMEC-1) dose-dependently. 
2. Phosphorylation of Extracellular Regulated Protein Kinases (Erk) and Focal Adhesion Kinase (FAK) were significantly inhibited by ACW0-Sul.

『原文』超連結

『全文下載』超連結


論文出處:Molecules. 2017 May 6;22(5). pii: E747. doi: 10.3390/molecules22050747.

論文名稱:In Vitro Anticancer Activity and Structural Characterization of Ubiquinones from Antrodia cinnamomea Mycelium.

作  者:Yen IC, Lee SY, Lin KT, Lai FY, Kuo MT, Chang WL

出 版 年:2017

分  類:抗癌

論文結論:Two new ubiquinones, named antrocinnamone and 4-acetylantrocamol LT3, were isolated along with six known ubiquinones from Antrodia cinnamomea (Polyporaceae) mycelium, exhibited potential and selective cytotoxic activity against three human cancer cell lines. The suppression by 4-acetylantrocamol LT3 stopped the cell cycle at the beginning of the G2-M phase.

『原文』超連結

『全文下載』超連結


論文出處:國防醫學院 醫學科學研究所

論文名稱:固態培養牛樟芝化學成分及藥理活性之研究

作  者:嚴逸釗

出 版 年:2017

分  類:抗癌

論文結論:從固態培養的牛樟芝(Antrodia cinnamomea)菌絲體中分離出十三個化合物,其中十個為泛醌類(ubiquinones)化合物:antrocamol LT1 (1)、antrocamol LT2 (2)、antrocamol LT3 (3)、4-acetylantrocamol LT3 (4)、antroquinonol (5)、4-acetylantroquinonol (6)、antroquinonol B (7)、4-acetylantroquinonol B (8)、quinone Q3 (9)、antrocinnamone (10),兩個為苯類(benzenoids)化合物:4,7-dimethoxy-5-methyl-1,3-benzodioxole (11)、2,4-dimethoxy-6-methyl-benzene-1,3-diol (12),ㄧ個為丁烯二酸類(maleic acid)化合物:antrodin A (13)。泛醌類化合物(特別是具有4-hydroxy-cyclohex-2-enone及侧鏈具羥基的化合物)對於癌細胞的毒殺效果較佳。另外,4-acetylantrocamol LT3 (4)對HepG2肝癌細胞之細胞週期 sub G1期阻滯,可能會導致細胞凋亡。

『原文』超連結

『全文下載』超連結


論文出處:國立彰化師範大學 生物技術研究所

論文名稱:小腸專一性啟動子表現鮭魚delta5和6去飽和脂肪酶轉基因斑馬魚抑制Streptococcus iniae生長以及對免疫調節的影響

作  者:賴力瑋

出 版 年:2015

分  類:抗發炎

論文結論:樟芝蟲草萃取液在10-3倍率的稀釋下,可以看到對於斑馬魚模式試驗上能減緩NNV所造成的發炎病徵,並具抗氧化能力

『原文』超連結

『全文下載』超連結


論文出處:J Ethnopharmacol. 2017 Jun 8. pii: S0378-8741(16)31038-8. doi: 10.1016/j.jep.2017.06.004. [Epub ahead of print]

論文名稱:Antrodia cinnamomea sensitizes radio-/chemo-therapy of cancer stem-like cells by modulating microRNA expression.

作  者:Su YK, Shih PH, Lee WH, Bamodu OA, Wu ATH, Huang CC, Tzeng YM, Hsiao M, Yeh CT, Lin CM

出 版 年:2017

分  類:抗癌

論文結論:Antrodia cinnamomea mycelium and its ethyl acetate extracts showed anti-proliferation effects against all types of CSCs, especially the lung, breast, and head and neck squamous cell carcinoma CSCs. An association between the CSC-inhibitory effect of Antrodia cinnamomea and significant downregulation of several microRNAs and cancer stemness expression levels in brain and breast CSCs. Higher CD133 expression is associated with poor prognosis in glioblastoma and breast cancer patients.

『原文』超連結

『全文下載』超連結


論文出處:Molecules. 2017 Dec 26;23(1). pii: E51. doi: 10.3390/molecules23010051.

論文名稱:Antrodia cinnamomea Oligosaccharides Suppress Lipopolysaccharide-Induced Inflammation through Promoting O-GlcNAcylation and Repressing p38/Akt Phosphorylation.

作  者:Zheng J, Jiao S, Li Q, Jia P, Yin H, Zhao X, Du Y, Liu H

出 版 年:2017

分  類:抗發炎

論文結論:Two oligosaccharide products were prepared from Antrodia cinnamomea (AC) polysaccharides at 90 °C (ACHO) or 25 °C (ACCO), which displayed inhibitory effects on LPS-induced mRNA expression of pro-inflammatory cytokines including IL-6, IL-8, IL-1β, TNF-α and MCP-1 in macrophage cells in mice. The potential anti-inflammatory molecular mechanism may be associated with the promotion of protein O-GlcNAcylation, which further skewed toward the marked suppression of p38 and Akt phosphorylation.

『原文』超連結

『全文下載』超連結


 < 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 >  Last ›
top