學術論文
Academic papers
論文出處:中臺科技大學 醫學檢驗生物技術系所
論文名稱:樟芝萃取液對腦缺血大鼠大腦皮質脂質過氧化作用、抗氧化酵素活性與微量元素濃度的影響
作 者:簡仲陽
出 版 年:2013
分 類:抗發炎
論文結論:
論文出處:Mol Clin Oncol. 2015 Nov;3(6):1375-1380. Epub 2015 Sep 15.
論文名稱:A phase I multicenter study of antroquinonol in patients with metastatic non-small-cell lung cancer who have received at least two prior systemic treatment regimens, including one platinum-based chemotherapy regimen.
作 者:Lee YC, Ho CL, Kao WY, Chen YM
出 版 年:2015
分 類:抗癌
論文結論:This first in-human phase I study of antroquinonol included patients with metastatic non-small-cell lung cancer. An open-label, dose escalation, pharmacokinetic (PK) study was conducted to determine the maximum tolerable dose (MTD), dose-limiting toxicities (DLTs), and safety/tolerability and preliminary efficacy profiles of antroquinonol. Treatment with antroquinonol was generally safe and well tolerated, without DLTs. And the recommended dose level for a phase II study is ≥600 mg daily.
論文出處:Oxid Med Cell Longev. 2017;2017:7841823. doi: 10.1155/2017/7841823. Epub 2017 Feb 27.
論文名稱:Hepatoprotective Effects of Antrodia cinnamomea: The Modulation of Oxidative Stress Signaling in a Mouse Model of Alcohol-Induced Acute Liver Injury.
作 者:Liu Y, Wang J, Li L, Hu W, Qu Y, Ding Y, Meng L, Teng L, Wang D
出 版 年:2017
分 類:抗發炎
論文結論:Antrodia cinnamomea (AC) reduced the incidence rate of necrosis, inflammatory infiltration, fatty droplets formation, and cell apoptosis. Reduced the expression of cleaved caspase-3, -8, and -9 and the levels of phosphor-protein kinase B (Akt) and phosphor-nuclear factor-κB (NF-κB) in liver of the mouse model.
論文出處:中國醫藥大學 營養學系
論文名稱:樟芝萃取物(AC-0)抑制頭頸部細胞癌(FaDu-twist)的生長及轉移作用與降低裸鼠移植腫瘤的生長
作 者:邱立雯
出 版 年:2015
分 類:抗癌
論文結論:
論文出處:中國醫藥大學 藥物化學研究所
論文名稱:牛樟芝萃取物對四氯化碳引發大鼠肝纖維化的保護作用
作 者:謝杰儒
出 版 年:2013
分 類:抗發炎
論文結論:椴木栽培的牛樟芝(Taiwanofungus camphoratus)子實體超臨界萃取物(TCSE)能抑制四氯化碳誘導的肝纖維化,經由抑制肝星狀細胞(hepatic stellate cell;HSC)的活化來達到保肝作用。(TCSE對於alanine transaminase、aspartate transaminase均有顯著下降,白蛋白則是顯著回升。能抑制膠原蛋白的產生。顯著提升抗氧化能力。有效降低alpha smooth muscle actin (α-SMA)的產生。)
論文出處:Int J Biol Macromol. 2015 Mar;74:476-82. doi: 10.1016/j.ijbiomac.2015.01.004. Epub 2015 Jan 10.
論文名稱:Anti-metastatic effects of antrodan, the Antrodia cinnamomea mycelia glycoprotein, in lung carcinoma cells.
作 者:Fa KN, Yang CM, Chen PC, Lee YY, Chyau CC, Hu ML
出 版 年:2015
分 類:抗癌
論文結論:Antrodan was isolated from Antrodia cinnamomea mycelia, significantly inhibit invasion and migration of Lewis lung carcinoma (LLC) cells.
論文出處:Biomed Res Int. 2017;2017:9374026. doi: 10.1155/2017/9374026. Epub 2017 Mar 23.
論文名稱:Antifatigue Effects of Antrodia cinnamomea Cultured Mycelium via Modulation of Oxidative Stress Signaling in a Mouse Model.
作 者:Liu Y, Li L, An S, Zhang Y, Feng S, Zhao L, Teng L, Wang D
出 版 年:2017
分 類:抗發炎
論文結論:The antifatigue properties of Antrodia cinnamomea may be one such modulation mechanism via oxidative stress-related signaling in mice.
論文出處:中國醫藥大學 藥學系
論文名稱:牛樟芝乙醇萃取物抑制人類非小細胞肺癌以及人類肝癌細胞遷移相關分子機制
作 者:陳穎儀
出 版 年:2015
分 類:抗癌
論文結論:
論文出處:長庚大學 醫學生物技術暨檢驗學系
論文名稱:牛樟芝酒精萃取液藉由抑制NLRP3發炎小體路徑活化進而減緩發炎細胞激素IL-1β與IL-18的分泌
作 者:吳弦璞
出 版 年:2013
分 類:抗發炎
論文結論:牛樟芝酒萃液可明顯地抑制受LPS及ATP刺激後的人類THP-1巨噬細胞中前發炎細胞激素IL-1β和IL-18的生成,也能抑制caspase-1的活化以及參與在NLRP3發炎小體活化路徑中的成分蛋白NLRP3的生成,此外也抑制P2X7受器的表現及活性氧(ROS)的生成,來達到抑制發炎反應發生的功效
論文出處:J Nat Med. 2015 Oct;69(4):513-21. doi: 10.1007/s11418-015-0916-6. Epub 2015 May 8.
論文名稱:2,3,5-Trimethoxy-4-cresol, an anti-metastatic constituent from the solid-state cultured mycelium of Antrodia cinnamomea and its mechanism.
作 者:Lin CC, Chen CC, Kuo YH, Kuo JT, Senthil Kumar KJ, Wang SY.
出 版 年:2015
分 類:抗癌
論文結論:An anti-metastatic compound, 2,3,5-trimethoxy-4-cresol (TMC), was isolated from the solid-state cultured mycelium of Antrodia cinnamomea. TMC effectively suppressed movement, migration and invasion of lung cancer cells. Reduced protein expression of Akt, MMP-2 and MMP-9 and enhanced E-cadherin and TIMP-1 protein expression.
論文出處:Org Lett. 2017 Jun 13. doi: 10.1021/acs.orglett.7b01468. [Epub ahead of print]
論文名稱:Galactomannan from Antrodia cinnamomea Enhances the Phagocytic Activity of Macrophages.
作 者:Perera N, Yang FL, Chang CM, Lu YT, Zhan SH, Tsai YT, Hsieh JF, Li LH, Hua KF, Wu SH
出 版 年:2017
分 類:抗發炎
論文結論:Galactomannan with an octasaccharide-repeating unit (ACP) was isolated from Antrodia cinnamomea. ACP enhanced the phagocytosis and bactericidal activity of J774A.1 murine macrophages against Escherichia coli, with prospects for developing a new immunomodulatory compound or adjuvant in immunotherapy and vaccination.
論文出處:中華醫事科技大學 醫學檢驗生物技術系
論文名稱:牛樟芝甲醇萃取物誘發A549 肺腺 癌細胞自我凋亡機制之探討
作 者:許筌翔
出 版 年:2014
分 類:抗癌
論文結論:牛樟芝萃取物誘發肺癌細胞A549自我凋亡,發現cytochrome C、Caspase-9、Caspase-3、Caspase-7、PARP蛋白質的表現量增加,BCL-XL的protein表現量會減少
論文出處:國立臺灣海洋大學 食品科學系
論文名稱:牛樟芝減緩小鼠由順鉑誘導肝毒性及增加抗腫瘤反應
作 者:許文邁
出 版 年:2013
分 類:抗發炎
論文結論:牛樟芝可藉由抗發炎以及抗氧化導致減緩化療藥物(順鉑)對於HepG2的毒殺作用。進一步證明牛樟芝可以減緩化療小鼠體重流失及減少血清中GOT和GPT的含量可能是藉由減少發炎細胞激素(IL-6、TNF-α及iNOS)及抑制肝細胞凋亡。此外,牛樟芝可以向下調節NF-κB增加促細胞凋亡蛋白(Bax)的表現量並減少抗細胞凋亡蛋白(Bcl-2)的表現量
論文出處:PLoS One. 2015 Sep 1;10(9):e0136782. doi: 10.1371/journal.pone.0136782. eCollection 2015.
論文名稱:Apoptosis of Hepatocellular Carcinoma Cells Induced by Nanoencapsulated Polysaccharides Extracted from Antrodia Camphorata.
作 者:Chang JS, Kuo HP, Chang KL, Kong ZL
出 版 年:2015
分 類:抗癌
論文結論:ACE polysaccharides, ACE/CS and ACE/S all could damage the Hep G2 cell membrane and cause cell death, especially in the ACE/CS group. The encapsulation of ACE polysaccharides by chitosan-silica nanoparticles may provide a viable approach for enhancing anti-tumor efficacy in liver cancer cells.
論文出處:Hepatol Res. 2016 Mar;46(3):E15-25. doi: 10.1111/hepr.12516. Epub 2015 Apr 7.
論文名稱:Identification of antrodin B from Antrodia camphorata as a new anti-hepatofibrotic compound using a rapid cell screening method and biological evaluation.
作 者:Geng Y, Wang J, Sun Q, Xie M, Lu ZM, Xu HY, Shi JS, Xu ZH
出 版 年:2016
分 類:抗發炎
論文結論: