學術論文
Academic papers
論文出處:J Pharm Biomed Anal. 2015;111:266-76. doi: 10.1016/j.jpba.2015.04.010. Epub 2015 Apr 10.
論文名稱:Metabolites identification and multi-component pharmacokinetics of ergostane and lanostane triterpenoids in the anticancer mushroom Antrodia cinnamomea.
作 者:Qiao X, Wang Q, Ji S, Huang Y, Liu KD, Zhang ZX, Bo T, Tzeng YM, Guo DA, Ye M
出 版 年:2015
分 類:抗癌
論文結論:The low-polarity ergostanes (antcins B and C) undertook hydrogenation (C-3 or C-7 carbonyl groups) or hydroxylation to produce polar metabolites. High-polarity ergostanes (antcins H and K) and Δ(7,9(11)) lanostanes were metabolically stable. The ergostanes were generally absorbed and eliminated rapidly, whereas the lanostanes remained in the plasma at a low concentration for a relatively long time. High-polarity ergostanes are the major plasma-exposed components of Antrodia cinnamomea, and may play an important role in its therapeutic effects.
論文出處:BMC Complement Altern Med. 2015 Jul 16;15:237. doi: 10.1186/s12906-015-0768-3.
論文名稱:Effects of Antrodia camphorata extracts on anti-oxidation, anti-mutagenesis and protection of DNA against hydroxyl radical damage.
作 者:Hsieh YL, Wu SP, Fang LW, Hwang TS
出 版 年:2015
分 類:抗發炎
論文結論:Antrodia camphorata is a non-toxic and novel material with antioxidant, antimutagenic and DNA-protective activities. That reducing and scavenging activities against superoxide anion radical and also exhibited protective effects on DNA against hydroxyl radical-induced damage.
論文出處:國立臺東大學 生命科學系
論文名稱:牛樟芝子實體純化物antcin A在肝癌異種移植模型中誘導腫瘤細胞凋亡機制探討
作 者:張力中
出 版 年:2014
分 類:抗癌
論文結論:
論文出處:輔仁大學 營養科學系
論文名稱:人工段木培養之牛樟芝子實體萃取物對半乳糖胺誘發大鼠 急性肝損傷之保護作用
作 者:劉家瑜
出 版 年:2012
分 類:抗發炎
論文結論:給予大鼠半乳糖胺 (D-GalN) 誘發其急性肝損傷,給予樟芝酒精萃取物可降低肝損傷大鼠血清中天門冬胺酸轉胺酶 (AST) 及丙胺酸轉胺酶 (ALT),並且降低血清中腫瘤壞死因子-α (TNF-α),提升肝臟超氧歧化酶 (SOD) 活性,降低血清脂質過氧化程度 (TBARS) ,達到減緩發炎、提升抗氧化能力及預防肝臟嚴重損傷
論文出處:Oncotarget. 2015 Sep 22;6(28):25741-54. doi: 10.18632/oncotarget.4348.
論文名稱:Antrodia cinnamomea alleviates cisplatin-induced hepatotoxicity and enhances chemo-sensitivity of line-1 lung carcinoma xenografted in BALB/cByJ mice.
作 者:Huang TH, Chiu YH, Chan YL, Wang H, Li TL, Liu CY, Yang CT, Lee TY, You JS, Hsu KH, Wu CJ
出 版 年:2015
分 類:抗癌
論文結論:Antrodia cinnamomea inhibited proliferation of line-1 lung carcinoma cells and rescued hepatic HepG2 cells from cisplatin-induced cell death in vitro.
論文出處:Bioorg Med Chem Lett. 2015 Oct 15;25(20):4637-41. doi: 10.1016/j.bmcl.2015.08.038. Epub 2015 Aug 20.
論文名稱:Immunosuppressive effect of zhankuic acid C from Taiwanofungus camphoratus on dendritic cell activation and the contact hypersensitivity response.
作 者:Lin MK, Lee MS, Chang WT, Chen HY, Chen JF, Li YR, Lin CC, Wu TS
出 版 年:2015
分 類:抗發炎
論文結論:Zhankuic acid C (ZAC), a ergostane triterpenoids from Taiwanofungus camphoratus, exhibits an immunosuppressive effect on dendritic cells (DC) activation and the contact hypersensitivity response in mice. That ZAC can potentially be used for treating chronic inflammation and autoimmune diseases.
論文出處:國立成功大學 生命科學系
論文名稱:牛樟芝子實體萃取化合物樟芝酸A在抗發炎作用的研究
作 者:陳宇楓
出 版 年:2014
分 類:抗癌
論文結論:樟芝酸A顯著改善小鼠體內脂多糖誘導的內毒素血症和沙門氏菌引起的腹瀉。另外,樟芝酸A在小鼠急性肝發炎時期是可以因抑制JAK2磷酸化而達到防止肝損傷
論文出處:國立嘉義大學 微生物免疫與生物藥學系所
論文名稱:樟芝菌絲體之定量分析與抗發炎活性成分
作 者:許恩翎
出 版 年:2012
分 類:抗發炎
論文結論:液態發酵之樟芝菌絲體及樟芝多醣體,以不同溶劑進行萃取,共分離純化出十七種成分。在LPS 誘導小鼠巨噬細胞RAW264.7 產生NO 試驗,antcin B,antrodin B,antrodin D,antrocinnamomin B 及 riboflavin 具有抗發炎活性
論文出處:Food Funct. 2014 Dec;5(12):3224-32. doi: 10.1039/c4fo00720d.
論文名稱:Anticancer effects on human pancreatic cancer cells of triterpenoids, polysaccharides and 1,3-β-D-glucan derived from the fruiting body of Antrodia camphorata.
作 者:Lee CI, Wu CC, Hsieh SL, Lee CL, Chang YP, Chang CC, Wang YZ, Wang JJ.
出 版 年:2014
分 類:抗癌
論文結論:Analyzed triterpenoids, polysaccharides and 1,3-β-D-glucan, three major effective components in Antrodia camphorata extracts (ACE). And shows great therapeutic potential due to its cytotoxic effects against BxPC-3 cells which include inhibiting cell migration and inducing mitochondria-mediated apoptosis.
論文出處:PLoS One. 2015 Feb 27;10(2):e0116191. doi: 10.1371/journal.pone.0116191. eCollection 2015.
論文名稱:The adjuvant effects of high-molecule-weight polysaccharides purified from Antrodia cinnamomea on dendritic cell function and DNA vaccines.
作 者:Lin CC, Pan IH, Li YR, Pan YG, Lin MK, Lu YH, Wu HC, Chu CL
出 版 年:2015
分 類:抗發炎
論文結論:The water extract of Antrodia cinnamomea high-molecular weight polysaccharides (AC hmwPSs) promoted pro-inflammatory cytokine production by dendritic cells (DCs) and the maturation of DCs. DC-induced antigen-specific T cell activation and Th1 differentiation were increased by AC hmwPSs.
論文出處:南台科技大學 生物科技系
論文名稱:固態培養紅樟芝與白樟芝菌絲體萃取物之抗氧化能力與抗前列腺癌細胞之活性探討
作 者:陳凱祥
出 版 年:2014
分 類:抗癌
論文結論:紅樟芝與白樟芝熱水萃取物酚類含量最高,乙醇萃取物粗三萜含量最高。紅樟芝與白樟芝熱水萃取物皆能夠給予卵巢癌細胞CHO-K1增加抗氧化能力,兩者保護能力明顯優於修復能力。樟芝抗前列腺癌細胞DU-145 活性,紅樟芝與白樟芝乙酸乙酯萃取物抑制增生能力最佳,白樟芝抑制轉移能力優於紅樟芝。且可使DU-145 細胞週期停滯在G2/M 期,抑制癌細胞增生
論文出處:國立中央大學 系統生物與生物資訊研究所
論文名稱:探討牛樟芝CCM111對細胞訊息傳遞之影響
作 者:林婷婷
出 版 年:2012
分 類:抗發炎
論文結論:牛樟芝萃取物CCM111對調控發炎反應的STAT3訊息傳導路徑具有顯著的抑制效果。在蛋白質層面也可以發現CCM111抑制了STAT3 蛋白質的磷酸化表現。除此之外,也降低STAT3蛋白質在Tyr705的磷酸化程度,抑制小鼠肝纖維化
論文出處:J Agric Food Chem. 2014 Jun 18;62(24):5625-35. doi: 10.1021/jf4056924. Epub 2014 Jun 6.
論文名稱:Antroquinonol D, isolated from Antrodia camphorata, with DNA demethylation and anticancer potential.
作 者:Wang SC, Lee TH, Hsu CH, Chang YJ, Chang MS, Wang YC, Ho YS, Wen WC, Lin RK.
出 版 年:2014
分 類:抗癌
論文結論:Antroquinonol D (3-demethoxyl antroquinonol), a new DNA methyltransferase 1 (DNMT1) inhibitor, was isolated from Antrodia camphorata. Inhibited the growth of breast cancer cells (MCF7, T47D, and MDA-MB-231) and the migratory potential.
論文出處:Am J Chin Med. 2015;43(7):1401-17. doi: 10.1142/S0192415X15500792. Epub 2015 Oct 18.
論文名稱:Antrodia cinnamomea Extract Inhibits Th17 Cell Differentiation and Ameliorates Imiquimod-Induced Psoriasiform Skin Inflammation.
作 者:Li MH, Wu HC, Yao HJ, Lin CC, Wen SF, Pan IH
出 版 年:2015
分 類:抗發炎
論文結論:Antrodia cinnamomea extract (AC) inhibited the differentiation of Th17 cells as well as the production of IL-17A, IL-21, and IL-22 from these cells. This effect was associated with the inhibition of STAT3 phosphorylation and RORγt expression.
論文出處:中華醫事科技大學 醫學檢驗生物技術系
論文名稱:牛樟芝甲醇萃取液誘導MCF-7乳癌細胞凋亡與生長抑制之研究
作 者:吳欣哲
出 版 年:2013
分 類:抗癌
論文結論:牛樟芝萃取物透過誘導細胞凋亡,抑制MCF-7乳癌的細胞生長