論文出處：Molecules. 2017 Dec 26;23(1). pii: E51. doi: 10.3390/molecules23010051.

論文名稱：Antrodia cinnamomea Oligosaccharides Suppress Lipopolysaccharide-Induced Inflammation through Promoting O-GlcNAcylation and Repressing p38/Akt Phosphorylation.

作　　者：Zheng J, Jiao S, Li Q, Jia P, Yin H, Zhao X, Du Y, Liu H

出 版 年：2017

分　　類：抗發炎

論文結論：Two oligosaccharide products were prepared from Antrodia cinnamomea (AC) polysaccharides at 90 °C (ACHO) or 25 °C (ACCO), which displayed inhibitory effects on LPS-induced mRNA expression of pro-inflammatory cytokines including IL-6, IL-8, IL-1β, TNF-α and MCP-1 in macrophage cells in mice. The potential anti-inflammatory molecular mechanism may be associated with the promotion of protein O-GlcNAcylation, which further skewed toward the marked suppression of p38 and Akt phosphorylation.

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論文出處：Oncotarget. 2017 Aug 4;8(57):96568-96587. doi: 10.18632/oncotarget.19951. eCollection 2017 Nov 14.

論文名稱：Activation of Nrf2-mediated anti-oxidant genes by antrodin C prevents hyperglycemia-induced senescence and apoptosis in human endothelial cells

作　　者：Senthil KKJ, Gokila VM, Wang SY

出 版 年：2017

分　　類：抗發炎

論文結論：Antrodin C (ADC), a maleimide derivative isolated from mycelia of Antrodia cinnamomea, may represent a promising intervention in diabetic-associated cardiovascular diseases by activating the Nrf2-dependent cellular anti-oxidant defense system.

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論文出處：J Immunol Res. 2017;2017:7807313. doi: 10.1155/2017/7807313. Epub 2017 Aug 13.

論文名稱：Natural Modulators of Endosomal Toll-Like Receptor-Mediated Psoriatic Skin Inflammation.

作　　者：Lai CY, Su YW, Lin KI, Hsu LC, Chuang TH

出 版 年：2017

分　　類：抗發炎

論文結論：Natural compounds derived from plants, fungi, and bacteria, including mustard seed, Antrodia cinnamomea extract, curcumin, resveratrol, thiostrepton, azithromycin, and andrographolide, inhibited psoriasis-like inflammation induced by the TLR7 agonist imiquimod in animal models. These natural modulators employ different mechanisms to inhibit endosomal TLR activation and are administered via different routes.

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論文出處：In Vivo. 2017 Sep-Oct;31(5):877-884.

論文名稱：Antrodia Cinnamomea Reduces Carbon Tetrachloride-induced Hepatotoxicity In Male Wister Rats.

作　　者：Shih YL, Wu MF, Lee CH, Yeh MY, Chou J, Liu JY, Lu HF, Huang YP, Liao NC, Chung JG

出 版 年：2017

分　　類：抗發炎

論文結論：Antrodia cinnamomea can either enhance liver recovering from CCl4 damage or attenuate CCl4 toxicity in rats.

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論文出處：Sci Rep. 2017 Jul 7;7(1):4862. doi: 10.1038/s41598-017-05072-y.

論文名稱：CCM111, the water extract of Antrodia cinnamomea, regulates immune-related activity through STAT3 and NF-κB pathways.

作　　者：Lin IY, Pan MH, Lai CS, Lin TT, Chen CT, Chung TS, Chen CL, Lin CH, Chuang WC, Lee MC, Lin CC, Ma N

出 版 年：2017

分　　類：抗發炎

論文結論：CCM111, the water extract of Antrodia cinnamomea, significantly inhibited the IL-6-stimulated STAT3 pathway and the LPS-stimulated NF-κB pathway in macrophages. Also decreased the phosphorylation of STAT3, Tyk2 and the nuclear translocation of p65. Moreover, CCM111 and F4, a fraction of CCM111, down-regulated nitric oxide (NO) production, the protein levels of iNOS and COX-2, and inflammatory cytokines in macrophage cells.

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論文出處：J Ethnopharmacol. 2017 Apr 18;202:200-207. doi: 10.1016/j.jep.2017.03.003. Epub 2017 Mar 6.

論文名稱：Effects of antrosterol from Antrodia camphorata submerged whole broth on lipid homeostasis, antioxidation, alcohol clearance, and anti-inflammation in livers of chronic-alcohol fed mice.

作　　者：Chang YY, Liu YC, Kuo YH, Lin YL, Wu YS, Chen JW, Chen YC

出 版 年：2017

分　　類：抗發炎

論文結論：Hepatoprotection of antrosterol (a bioactive constitute of sterols from Antrodia camphorata) is mostly attributed to its regulations of lipid homeostasis, antioxidant capability, alcohol metabolism, and anti-inflammation.

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論文出處：Environ Toxicol. 2017 Apr 3. doi: 10.1002/tox.22422. [Epub ahead of print]

論文名稱：Antrodia camphorata attenuates cigarette smoke-induced ROS production, DNA damage, apoptosis, and inflammation in vascular smooth muscle cells, and atherosclerosis in ApoE-deficient mice.

作　　者：Yang HL, Korivi M, Chen CH, Peng WJ, Chen CS, Li ML, Hsu LS, Liao JW, Hseu YC

出 版 年：2017

分　　類：抗發炎

論文結論：Fermented culture broth of Antrodia camphorata possesses effective antioxidant activity and decreased total cholesterol and triacylglycerol levels, against cigarette smoke extracts (CSE)-induced ROS production. In AC-treated A7r5 cells, improved CSE-induced morphological aberrations and cell death, upregulated SOD and catalase expressions. Suppressed ROS levels and inhibition of CSE-induced DNA damage and apoptosis.

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論文出處：PLoS One. 2017 Apr 6;12(4):e0174008. doi: 10.1371/journal.pone.0174008. eCollection 2017.

論文名稱：Prevention of TGF-β-induced early liver fibrosis by a maleic acid derivative anti-oxidant through suppression of ROS, inflammation and hepatic stellate cells activation.

作　　者：Yang KL, Chang WT, Hong MY, Hung KC, Chuang CC

出 版 年：2017

分　　類：抗發炎

論文結論：A maleic acid derivative, isolated from Antrodia camphorata mycelium, prevents liver fibrosis at an early phase both in vitro and in vivo through the inhibition of ROS, inflammation and the activation of HSC. Decreases ROS production, promoter activity of Cox-2 and Col 1A2, intracellular calcium, expression of alpha-smooth muscle actin (α-SMA), Smad4-p-Smad2/3 co-localization in cell nucleus and the DNA binding activity of Sp1.

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論文出處：J Ethnopharmacol. 2017 May 12. pii: S0378-8741(17)30084-3. doi: 10.1016/j.jep.2017.05.020. [Epub ahead of print]

論文名稱：Hepatoprotective activities of Antrodia camphorata and its triterpenoid compounds against CCl4-induced liver injury in mice.

作　　者：Li ZW, Kuang Y, Tang SN, Li K, Huang Y, Qiao X, Yu SW, Tzeng YM, Lo JY, Ye M

出 版 年：2017

分　　類：抗發炎

論文結論：Cultivation techniques remarkably affect the hepatoprotective activities of Antrodia camphorata. Antcin K and antcin B are the major hepatoprotective compounds of Antrodia camphorata, and the mechanism is related with anti-inflammation. Given its high natural abundance and good oral absorption, antcin K could be a promising drug candidate for liver injury.

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論文出處：Int J Biol Macromol. 2017 Jun 19. pii: S0141-8130(17)30558-5. doi: 10.1016/j.ijbiomac.2017.05.191. [Epub ahead of print]

論文名稱：β-D-glucan from Antrodia Camphorata ameliorates LPS-induced inflammation and ROS production in human hepatocytes.

作　　者：Chen Q, Tang H, Zha Z, Yin H, Wang Y, Wang Y, Li H, Yue L

出 版 年：2017

分　　類：抗發炎

論文結論：A water soluble Antrodia Camphorata polysaccharide was composed of β-D-glucan, coded as ACP1. Which consisted of →1,3)-linked-β-D-Glcp-(6→, →3)-linked-β-D-Glcp-(1→, and →6)-linked-α-D-Galp-(1→, with terminal β-D-Glcp and β-D-Galp. And ACP1 was very likely to alleviate oxidation and inflammation.

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論文出處：Antioxid Redox Signal. 2017 Feb 10;26(5):207-220. doi: 10.1089/ars.2016.6833. Epub 2016 Oct 11.

論文名稱：Antcin H Protects Against Acute Liver Injury Through Disruption of the Interaction of c-Jun-N-Terminal Kinase with Mitochondria.

作　　者：Huo Y, Win S, Than TA, Yin S, Ye M, Hu H, Kaplowitz N

出 版 年：2017

分　　類：抗發炎

論文結論：Antcin H (a triterpenoid isolated from Antrodia Camphorate) contributes to the hepatoprotective effect, and protects against liver injury through disruption of the binding of p-JNK to Sab, which interferes with the ROS-dependent self-sustaining activation of MAPK cascade.

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論文出處：Am J Chin Med. 2017;45(1):173-198. doi: 10.1142/S0192415X17500124. Epub 2017 Jan 13.

論文名稱：Fruiting Bodies of Antrodia cinnamomea and Its Active Triterpenoid, Antcin K, Ameliorates N-Nitrosodiethylamine-Induced Hepatic Inflammation, Fibrosis and Carcinogenesis in Rats.

作　　者：Tien AJ, Chien CY, Chen YH, Lin LC, Chien CT

出 版 年：2017

分　　類：抗發炎

論文結論：Antrodia cinnamomea water extract (ACW) and its active component, Antcin K, counteract N-nitrosodiethylamine (DEN)-induced hepatic injury and inflammation by the protective and therapeutic mechanisms of a direct scavenging reactive oxygen species (ROS) activity and an upregulation of anti-oxidant defense mechanisms.

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論文出處：Oxid Med Cell Longev. 2017;2017:7841823. doi: 10.1155/2017/7841823. Epub 2017 Feb 27.

論文名稱：Hepatoprotective Effects of Antrodia cinnamomea: The Modulation of Oxidative Stress Signaling in a Mouse Model of Alcohol-Induced Acute Liver Injury.

作　　者：Liu Y, Wang J, Li L, Hu W, Qu Y, Ding Y, Meng L, Teng L, Wang D

出 版 年：2017

分　　類：抗發炎

論文結論：Antrodia cinnamomea (AC) reduced the incidence rate of necrosis, inflammatory infiltration, fatty droplets formation, and cell apoptosis. Reduced the expression of cleaved caspase-3, -8, and -9 and the levels of phosphor-protein kinase B (Akt) and phosphor-nuclear factor-κB (NF-κB) in liver of the mouse model.

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論文出處：Biomed Res Int. 2017;2017:9374026. doi: 10.1155/2017/9374026. Epub 2017 Mar 23.

論文名稱：Antifatigue Effects of Antrodia cinnamomea Cultured Mycelium via Modulation of Oxidative Stress Signaling in a Mouse Model.

作　　者：Liu Y, Li L, An S, Zhang Y, Feng S, Zhao L, Teng L, Wang D

出 版 年：2017

分　　類：抗發炎

論文結論：The antifatigue properties of Antrodia cinnamomea may be one such modulation mechanism via oxidative stress-related signaling in mice.

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論文出處：Org Lett. 2017 Jun 13. doi: 10.1021/acs.orglett.7b01468. [Epub ahead of print]

論文名稱：Galactomannan from Antrodia cinnamomea Enhances the Phagocytic Activity of Macrophages.

作　　者：Perera N, Yang FL, Chang CM, Lu YT, Zhan SH, Tsai YT, Hsieh JF, Li LH, Hua KF, Wu SH

出 版 年：2017

分　　類：抗發炎

論文結論：Galactomannan with an octasaccharide-repeating unit (ACP) was isolated from Antrodia cinnamomea. ACP enhanced the phagocytosis and bactericidal activity of J774A.1 murine macrophages against Escherichia coli, with prospects for developing a new immunomodulatory compound or adjuvant in immunotherapy and vaccination.

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