學術論文


Academic papers

抗發炎

論文出處:Acta Pharmacol Sin. 2011 Jul;32(7):904-11. doi: 10.1038/aps.2011.36. Epub 2011 May 23.

論文名稱:Antcin A, a steroid-like compound from Antrodia camphorata, exerts anti-inflammatory effect via mimicking glucocorticoids.

作  者:Chen YC, Liu YL, Li FY, Chang CI, Wang SY, Lee KY, Li SL, Chen YP, Jinn TR, Tzen JT.

出 版 年:2011

分  類:抗發炎

論文結論:Five major antcins (A, B, C, H, and K) were isolated from fruiting bodies of Antrodia camphorata. The anti-inflammatory effect of Antrodia camphorata is, at least, partly attributed to antcin A that mimics glucocorticoids and triggers translocation of glucocorticoid receptor into nucleus to initiate the suppressing inflammation.

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論文出處:Acta Pharmacol Sin. 2011 Aug; 32(8): 981–982. Published online 2011 Aug 5. doi: 10.1038/aps.2011.104

論文名稱:Antcin A contributs to anti-inflammatory effect of Niuchangchih (Antrodia camphorata).
 

作  者:Lu ZM, Xu ZH.

出 版 年:2011

分  類:抗發炎

論文結論:

Chen et al demonstrated in human lung cancer cell A549 that antcin A was the active ingredient responsible for the anti-inflammatory effect of Antrodia camphorata, which mechanism triggered by glucocorticoids4. Hsien et al recently showed another anti-inflammatory activity compound, antrocamphin A, from Antrodia camphorata, resulted from suppressing pro-inflammatory molecule release via down-regulation of iNOS and COX-2 expression through NF-κB pathway5. Both the studies provide the potential of Antrodia camphorata to treat inflammation.

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論文出處:Bioorg Med Chem. 2011 Jan 1;19(1):677-83. doi: 10.1016/j.bmc.2010.10.032. Epub 2010 Oct 20.

論文名稱:Biologically active constituents from the fruiting body of Taiwanofungus camphoratus.

作  者:Shi LS, Chao CH, Shen DY, Chan HH, Chen CH, Liao YR, Wu SJ, Leu YL, Shen YC, Kuo YH, Lee EJ, Qian K, Wu TS, Lee KH.

出 版 年:2011

分  類:抗發炎

論文結論:Five new benzenoids, benzocamphorins A-E, and 10 recently isolated triterpenoids, camphoratins A-J, with 23 known compounds were isolated from the fruiting body of Taiwanofungus camphoratus. These compounds may use in traditional Chinese medicine (TCM) for the treatment of inflammation and cancer-related diseases.

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論文出處:Nat Prod Res. 2011 Sep;25(16):1488-96. doi: 10.1080/14786410903132563. Epub 2011 Jul 8.

論文名稱:Antioxidant activities of extracts and metabolites isolated from the fungus Antrodia cinnamomea.

作  者:Wu MD, Cheng MJ, Wang WY, Huang HC, Yuan GF, Chen JJ, Chen IS, Wang BC.

出 版 年:2011

分  類:抗發炎

論文結論:N-hexane, ethyl acetate [EtOAc] and n-BuOH of the culture broth from Antrodia cinnamomea were assayed with 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging and superoxide radical scavenging (SOD) assay. In EtOAc layer exhibited the best antioxidant activity, and isolated major antioxidant metabolites.

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論文出處:J Ethnopharmacol. 2011 Sep 1;137(1):575-84. doi: 10.1016/j.jep.2011.06.009. Epub 2011 Jun 16.

論文名稱:Anti-inflammatory effects of methanol extract of Antrodia cinnamomea mycelia both in vitro and in vivo.

作  者:Wen CL, Chang CC, Huang SS, Kuo CL, Hsu SL, Deng JS, Huang GJ.

出 版 年:2011

分  類:抗發炎

論文結論:Methanol extract of liquid cultured mycelia of Antrodia cinnamomea (MEMAC) has the anti-inflammatory property both in vitro and in vivo.

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論文出處: Immunology. 2010 Mar;129(3):351-62. doi: 10.1111/j.1365-2567.2009.03175.x. Epub 2009 Nov 11.

論文名稱:Administration of polysaccharides from Antrodia camphorata modulates dendritic cell function and alleviates allergen-induced T helper type 2 responses in a mouse model of asthma.

作  者:Liu KJ, Leu SJ, Su CH, Chiang BL, Chen YL, Lee YL

出 版 年:2010

分  類:抗發炎

論文結論:A. camphorata polysaccharides (GF2) may have therapeutic potential when used as an adjuvant for the immunomodulatory treatment of allergic asthma.

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論文出處:J Agric Food Chem. 2010 Mar 24;58(6):3859-66. doi: 10.1021/jf100530c.

論文名稱:Fruiting body of Niuchangchih (Antrodia camphorata) protects livers against chronic alcohol consumption damage.

作  者:Huang CH, Chang YY, Liu CW, Kang WY, Lin YL, Chang HC, Chen YC

出 版 年:2010

分  類:抗發炎

論文結論:High dosage Antrodia camphorata showed a hypercholesterolemic effect and reduced hepatic lipids in alcohol-fed rats.

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論文出處:Cancer Immunol Immunother. 2010 Aug;59(8):1259-72. doi: 10.1007/s00262-010-0852-y.

論文名稱:Promoting effect of Antrodia camphorata as an immunomodulating adjuvant on the antitumor efficacy of HER-2/neu DNA vaccine.

作  者:Huang CH, Chang CC, Lin CM, Wang ST, Wu MT, Li EI, Chang HC, Lin CC.

出 版 年:2010

分  類:抗發炎

論文結論:Antrodia camphorata represents a promising immunomodulatory adjuvant. Compared with the mice that received the HER-2/neu DNA vaccine alone, co-treatment with AC suppressed tumor growth and extended the survival rate.

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論文出處:J Agric Food Chem. 2010 Jun 23;58(12):7445-52. doi: 10.1021/jf1013764.

論文名稱:Analgesic effects and the mechanisms of anti-inflammation of ergostatrien-3beta-ol from Antrodia camphorata submerged whole broth in mice.

作  者:Huang GJ, Huang SS, Lin SS, Shao YY, Chen CC, Hou WC, Kuo YH.

出 版 年:2010

分  類:抗發炎

論文結論:An active ingredient from Antrodia camphorata (AC), Ergostatrien-3beta-ol (ST1), that anti-inflammatory mechanisms might be related to the decrease in the level of MDA, iNOS, and COX-2 in the edema paw via increasing the activities of CAT, SOD, and GPx in the liver through the suppression of TNF-alpha and NO.

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論文出處:Food Chem Toxicol. 2010 Aug-Sep;48(8-9):2319-25. doi: 10.1016/j.fct.2010.05.066. Epub 2010 Jun 1.

論文名稱:Antrodia camphorata suppresses lipopolysaccharide-induced nuclear factor-kappaB activation in transgenic mice evaluated by bioluminescence imaging.

作  者:Hseu YC, Huang HC, Hsiang CY.

出 版 年:2010

分  類:抗發炎

論文結論:The anti-inflammatory action in vivo of fermented culture broth of Antrodia camphorata in terms of LPS-induced NF-kappaB activation in transgenic mice.

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論文出處:Bioorg Med Chem. 2010 Sep 15;18(18):6896-904. doi: 10.1016/j.bmc.2010.07.024. Epub 2010 Jul 16.

論文名稱:Structure and functions of gamma-dodecalactone isolated from Antrodia camphorata for NK cell activation.

作  者:Chen CJ, Vijaya Krishna R, Tsai CC, Wu WH, Chao LK, Hwang KH, Chien CM, Chang HY, Chen ST.

出 版 年:2010

分  類:抗發炎

論文結論:A volatile compound, gamma-dodecalactone (gamma-DDL), was isolated from the culture medium of Antrodia camphorata. The gamma-DDL not only can induce NK cells to express CD69 but also stimulate NK cells to secrete cytotoxic molecules (FasL and granzyme B) and Th1 cytokines (TNF-alpha and INF-gamma).

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論文出處:Nutr Cancer. 2010;62(5):593-600. doi: 10.1080/01635580903532341.

論文名稱:Dietary effect of Antrodia Camphorate extracts on immune responses in WEHI-3 leukemia BALB/c mice.

作  者:Lin SY, Sheen LY, Chiang BH, Yang JS, Pan JH, Chang YH, Hsu YM, Chiang JH, Lu CC, Wu CL, Chung JG.

出 版 年:2010

分  類:抗發炎

論文結論:Antrodia camphorata has ability to promote immune responses and to exhibited antileukemia activity in WEHI-3 leukemia BALB/c mice. And prolonged the survival rate and prevented the body weight loss.

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論文出處:J Agric Food Chem. 2010 Mar 10;58(5):3153-8. doi: 10.1021/jf903638p.

論文名稱:Antrocamphin A, an anti-inflammatory principal from the fruiting body of Taiwanofungus camphoratus , and its mechanisms.

作  者:Hsieh YH, Chu FH, Wang YS, Chien SC, Chang ST, Shaw JF, Chen CY, Hsiao WW, Kuo YH, Wang SY.

出 版 年:2010

分  類:抗發炎

論文結論:The bioactive compound of Taiwanofungus camphoratus and illustrates the mechanism by which it confers its anti-inflammatory activity.

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論文出處:J Nat Prod. 2010 Nov 29;73(11):1756-62. doi: 10.1021/np1002143. Epub 2010 Oct 28.

論文名稱:Camphoratins A-J, potent cytotoxic and anti-inflammatory triterpenoids from the fruiting body of Taiwanofungus camphoratus.

作  者:Wu SJ, Leu YL, Chen CH, Chao CH, Shen DY, Chan HH, Lee EJ, Wu TS, Wang YH, Shen YC, Qian K, Bastow KF, Lee KH.

出 版 年:2010

分  類:抗發炎

論文結論:Ten new triterpenoids, camphoratins A-J, with 12 known compounds were isolated from the fruiting body of Taiwanofungus camphoratus. Have cytotoxicity against KB and KB-VIN human cancer cell lines. And exhibited anti-inflammatory NO-production inhibition activity.

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論文出處:Planta Med. 2009 Apr;75(5):512-6. doi: 10.1055/s-0029-1185305. Epub 2009 Feb 2.

論文名稱:New constituents with iNOS inhibitory activity from mycelium of Antrodia camphorata.

作  者:Yang SS, Wang GJ, Wang SY, Lin YY, Kuo YH, Lee TH.

出 版 年:2009

分  類:抗發炎

論文結論:

Five compounds from mycelium of Antrodia camphorata were isolated by the guidance of an inducible nitric oxide synthase (iNOS) inhibitory assay analysis. 
1. 2,4-dimethoxy-6-methylbenzene-1,3-diol and antrodin D significantly inhibited NO production without any cytotoxicity. 
2. Antroquinonol B and 4-acetyl-antroquinonol B possessed greater effects on NO inhibition, but displayed cytotoxicity at considerably higher concentrations. 
3. 2,3-(methylenedioxy)-6-methylbenzene-1,4-diol showed the lowest cell viability in treated cells.

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