陳介甫
志英植物研究發展基金會
國家中醫藥研究所

目前主要人類的共同祖先，在七萬年到十萬年前約二千人，從南非先後移居到中
東，繼西向歐洲，東向亞洲，最慢三到一萬年前，越過白令海峽而到美洲或散布在南太平洋群島上。人類在不同地方困難的求生繁殖，至今已逾七十二億，龐大的人口讓我們更了解地球不同資源的不足。歷史上不同動物被獵殺或馴化，不同植物被採收，或種植而為最重要的食物。而菇類的食用、藥用或毒性也被廣泛的利用。
公元前五世紀的希臘詩人，歐里庇得斯(Euripides, 480 – 406 BC)的妻子及三個孩子
吃毒蕈去世。奧古斯都大帝，他指定的繼承人、姪兒 Marcellus 及其孫子 Gaius, Lucius
Caesar 先後被他的妻子莉薇雅(Livia Drusilla, 55BC-29AD)所毒殺，而使莉薇雅和她前夫的兒子 Tiberius 為皇帝。克勞狄(Claudius)皇帝在公元 54 年被其妻阿格里匹娜(Agrippina) 用毒蕈毒殺，而使阿格里匹娜與前夫所生的兒子尼祿(Nero Claudius Caesar)為皇帝。她們所用的毒藥應是瓢蕈(Amanita phalloids, 中毒症狀似飲酒過量，服用後六到二十四小
時引起嘔吐等嚴重胃腸道症狀，經過一段靜止期，繼之肝腎肺衰竭，低血糖、頭痛、神智不清而死亡)。至今吃有毒的蕈，仍時有報導。但是，印度最古老的吠陀經、梨俱吠(Rig
Veda)所述的 Soma 就是會引起幻覺的蠅蕈(A. muscaria)。而從蠅蕈，德國藥理學家 Schmieaeberg 在 1869 年分離到蠅蕈素(muscarine)，所生產的神經系統作用稱為類蠅蕈素作用(muscarinic effects)，這知識在神經藥理學上佔重要的作用。無毒的菇類是重要的食物，而其中所含不同成份的生理生化作用，使得菇類也是重要的健康食品，甚至新藥開發的對象。 台灣的牛樟芝，過去很多學者，包括這次參與研討會的專家都有貢獻及興趣。本人與同事周正仁、黃瑞齡、盧美光、汪貴珍等研究員、李一宏醫師、農業試驗所張東柱研究員及台大許瑞祥教授篩選出抗 B 型肝炎病毒的牛樟芝菌種，對其 DNA 加以定序，及做一些生物活性研究，而後續研究也在不同學術機構，學校進行中。野生牛樟芝是昂貴的，大多數人無法享用。細胞、組織培養或生物基因工程可以幫我們不依賴空間及時間，在嚴謹條件下，生產品質一致的產品，才可能被使用者信賴，進行臨床療效評估成為藥品。
目前有關牛樟芝培養方法、化學成分及生物活性的報導很多，並進入對發炎體影響的層次。本次研討會能在中研院由生化所的系統生物學專家陳水田博士召開研討會，獲不同單位協助，且有大陸學者參與，是牛樟芝研究向前的重要一步，讓我們共同努力。 敬祝健康               

-Contents- Day1 May, 27(Tuesday)
9:20-10:10 Keynote speaker吳永昌 Yang-Chang Wu ……………………………..1
10:30-11:00吳宗正Tzong-Zeng Wu…………..…………..…………..……………...5 11:00-11:30廖俊旺Liao, Jiunn-Wang……………………………………………….10
11:30-12:00 林志彬 Zhi-Bin Lin…………………………………………………....17 13:30-14:00王宮Gong Wang………………………………………………………..21 14:00-14:30陳福安 Fu-An Chen…………………………………………………....23 14:30-15:00葉敏 Min Ye……………………………………………………………29
15:00-15:30 Vikineswary Sabaratnam……………………………………………….33 16:00-16:30 Wen-Yuan Hu…………………………………………………………..37
16:30-17:00 曾耀銘 Yew-Min Tzeng……………………………………………….41 17:00-17:30吳世雄 Shih-Hsiung Wu……………………………………………….46
17:30-18:00盧美光 Mei-Kuang Lu…………………………………………………50
12:00-13:30 Poster

l	Whitening efficacy evaluation of extracts from submerged cultivation and solid-state fermentation of Antrodia cinnamomea……………………………...55
l	CCM111 regulates inflammation activity and affects immune-related signaling pathways………………………………………………………………………...56
l	Zhankuic Acid A Isolated from Taiwanofungus camphoratus Is a Novel Selective TLR4/MD-2 Antagonist with Anti-Inflammatory Properties…………………...57
l	Optimal synthesis and discovery of drug doses………………………………58
l	Genetic architecture and molecular phylogeny underlying fruiting body formation and meiotic system of Taiwanofungus camphoratus (syn. Antrodia cinnamomea)……………………………………………………………………59
l	The metabolites and anti-cancer activity analysis of different Antrodia cinnamomea samples…………………………………………………………....60
l	Xanthine oxidase inhibitory activity of Antrodia cinnamomea………………61
l	Micropropagation of Fast-growing Type Cinnamomum kanehirai Hay and Efficient Cuttage………………………………………………………………62
l	Assess The Development of Antrodia camphorata Sorghum Liquor. (Safety and long-term low-dose liver protection experiments)……………………………...63
l	Antrodia Cinnamomea alleviates Bleomycin-induced Pulmonary Fibrosis in Mice……………………………………………………………………………..64
l	The Medicinal Fungus Antrodia cinnamomea Suppresses Inflammation by Inhibiting the NLRP3 Inflammasome…………………………………………..65
l	YMGKI-2, an Active Component of Antrodia Cinnamomea Mycelia on

Targeting Cancer Initiating Cells by Promoting Cell Differentiation via Dual
Inhibition of STAT3 and Src Activity…………………………………………...66

l	Dehydroeburicoic acid, an antileukemic triterpene from the fruiting bodies of dish-cultured Antrodia cinnamomea…………………………………………………67
l	New Extraction and Separation Procedure of Anti-tumor Triterpenoids and Immunostimulatory Polysaccharides from Dish-Cultured Antrodia cinnamomea …………………………………………………………………………………..68
l	New Approach for Characterizing and Quantitating of Antrodia cinnamomea Benzenoid Components with NMR, HPLC-PDA and LC-Tandem MS: Comparing the Wild Fruiting Bodies and Its Artificial Cultivation Commercial Products…………………………………………………………...69
l	Immunological Effects and Chemical Structure of Antrodia cinnamomea Polysaccharides…………………………………………………………………70
l	Study on antioxidant activities of Antrodia cinnamomea ethanol extracts and their protective role against oxidative stress induced cell death in 3T3-L1 preadipocytes……………………………………………………………………71
l	Genomic analyses of the medicinal mushroom Antrodia cinnamomea for its

metabolite biosynthesis and sexual development……………………………….73 
 
Day2 May, 28(Wednesday)
9:10-10:00 Keynote speaker-2 鍾順昌 Shung-Chang Jong………………………74
10:00-10:30 袁國芳 Yuan-Gwo Fang…………………………………………….102 11:00-11:30 謝松源 Sung-Yuan Hsieh……………………………………………..106
11:30-12:00 張東柱 Tun-Tschu Chang……………………………………………..109
13:30-16:30梁茂昌Mao-Chang Liang(Workshop-1)……………………………..114
 
Day3 May, 29(Thursday)
9:00-12:00 陳水田 Shui-Tein Chen(Workshop-2)………………………………124
 
台灣牛樟菇菌產業聯盟總召集人 粘銘昌簡介………………………………126
 
 
 
 
 

吳宗正
 
 
 

1. 現職 國立東華大學 生命科學系/生物技術研究所 教授 (1997~ )

       2.學歷1987~ 1990 國立台灣大學 農業化學研究所生化組博士

3. 經歷1990~ 1996 財團法人生物技術開發中心 生物化學組研究員 

                  1996~ 1997 工研院電子工業研究所 前瞻計畫研究組正研究員
 

4. 研究興趣及專長 生物感測與生物電子/藥用真菌/天然物分離、純化、功能驗證與應用

 

5. 榮譽/學術榮譽 聯合國智慧財產組織(WIPO)傑出發明金牌得主(1992) – 多元陣列嗅覺生物感測器

 

6. 研究成果簡述 結合液固態培養及微生物誘導樟芝菇化之研究 牛樟芝子實體萃取物對於細胞抗發炎作用

牛樟芝子實體萃取物對於人類肝癌細胞株HepG2在動物實驗內分子機制之研究 牛樟芝子實體萃取物對於人類大腸癌細胞株Caco2在動物實驗內分子機制之研究
牛樟芝子實體萃取物對於人類前列腺癌細胞株LNCaP、PC-3在細胞及動物實驗
內分子機制之研討及研究
特定牛樟芝子實體純化物對人類卵巢癌細胞株PA-1、OVCAR-3之影響 牛樟芝子實體萃取物保護人類上皮細胞之研究 牛樟芝中抑制血管新生活性成分之研究 牛樟芝子實體純化物對人類胃癌細胞株 AGS 之細胞凋亡機制探討 牛樟芝子實體粗萃取及純化物抑制人類食道癌細胞株之研究 牛樟芝子實體萃取物誘導肺癌細胞進行細胞凋亡之研究
 
 
 
Tzong Zeng Wu Current Positions:
    Professor, Department of Life Science and Graduate Institute of Biotechnology, National Dong Hwa University (1997~ )
Education:
PhD in Agricultural Chemistry (1990), National Taiwan University 
 
Professional Experiences:
1996 - 2000     Associate Professor, Department of Life Science and Graduate
Institute of Biotechnology, National Dong Hwa University
1996/2~1996/7  Research Fellow, ERSO/ITRI (Industrial Technology Research Institute), Taiwan
1990~1996      Researcher Fellow, Biochemistry Division, Development Center for Biotechnology, Taiwan
Specialties:
 Biosensors and Bioelectronics
Medical fungus
Natural products isolation , purification, characterization and application
Awards and Honors:
Awards of WIPO (World Intellectual Property organization) gold medal for the outstanding invention – Multi-array piezoelectric olfactory biosensor (1992)
Selected publication

l	In vitro introduction of fruiting body in Antrodia cinnamomea – a medicinally improtant fungus. Botanical Buletin of Academia Sinica. 47: 267-272 (2006)
l	The apoptotic mechanism of Taiwanofungus camphoratus fruiting bodies’ extracts on human liver cancer HepG2 cell line
l	The apoptotic mechanism of Taiwanofungus camphoratus fruiting bodies’ extracts on human liver cancer Caco-2 cell line
l	Extract from Taiwanofungus camphoratus fruiting bodies induce apoptosis in human lung carcinoma cell lines
l	Effect of specific compound from Taiwanofungus camphoratus fruiting body’s

on ovarian carcinoma cell lines PA-1 and OVCAR-3

l	The Anti-tumor mechanism of bioactive components isolated from Taiwanofungus camphoratus fruiting body on Human Prostate Cancer Cells
l	Inhibitory effects of crude extract and purified components of Taiwanofungus camphoratus fruting bodies on human esophageal carcinoma cell lines
l	Anti-angiogenic activities of active components isolated from Antrodia

Camphorata fruiting body
 
 
 
實驗動物毒性病理判讀與量化評估
The qualitative and quantitative evaluations of toxicopathology in  the laboratory animal studies
廖俊旺 
 
摘要： 
實驗動物毒理學之研究數據，可提供食品、藥毒物及化學產品對人體、動物及環境生態安全性相關資訊，並探討對生物體傷害之作用機制，適時作為臨床應用及管理參考依據。國際上已建立各種短期及長期之動物試驗規範，經由檢測實驗動物之各項生理值及病理學的判讀評估，直接或間接的證實藥毒物使用之安全性。但毒理試驗之操作或毒性病理判讀方式不當，會影響試驗結果之正確性，不可忽視。毒性病理學為一結合毒理學及病理學之科學，除需具有獸醫病理學對各種疾病及病變描述等專業知識外，尚需熟悉不同實驗動物及各種毒理試驗規範。同時，毒性病理判讀需達到完整、精確及一致性，且能分辨自發性與毒性病變之不同，綜合試驗物質在整體試驗中造成病變與否，為判讀臨床前動物安全性試驗重要證據之一。肉眼及組織病理觀察與記錄，為動物毒理試驗之最後階段。促成精確的毒性病理判讀，需有完整的樣品採集、正確的組織臟器固定保存、良好的組織修片、切片製作品質及染色。一般例行性切片染色常使用蘇木素及伊紅染色，蘇木紫可染出細胞核及核仁等鹼性物質使呈藍色，伊紅則對酸性物質具親合性，可將細胞內蛋白質染成紅色。利用此二種染劑，可區分出正常細胞結構、形態、大小及組織排列。毒性病理判讀之半定量分析首先需使用共通病理診斷專有名詞描述，依組織病變不同加以區分等級，並列表進行組間積分比較。對於難以區分細胞性或細胞來源之病變，可用特殊化學染色法，標定具特殊性細胞，如結締組織或纖維化，利用Sirius red染色法可染出紅色區，藉此可偵測細胞內存在部位及量的變化。另外，細胞膜抗原容易受到福馬林溶液固定之破壞，常以新鮮標本冷凍切片處理，但因細胞形態固定不佳，病變不易判讀。經福馬林液固定後石臘標本染色，雖因抗原性遭破壞，但仍可用組織免疫化學染色法，利用加熱回復抗原特性，將特殊抗原於封臘之組織切片重新再表現。即利用初級抗體覆蓋組織切片一段反應時間後，以次級抗體處理，再利用呈色物質標識出抗原位置。如常用：增殖性細胞核表現抗原 (PCNA)輔助判定增生細胞。對於一般認為病理判讀常有主觀意識，可藉由影像處理系統定量分析並提供較客觀數據加以修正。因此，毒性病理之正確判讀，除可善用組織病變不同之半定量描述分析外，亦可應用影像處理系統之數位病理切片，可客觀加以輔助，兩者結合後可使病理報告內容更加準確，達到動物
毒理試驗最終目的，訂定「無毒害作用劑量值(NOAEL)」之參考依據。
 
 
 
 
廖俊旺 Liao, Jiunn-Wang 

教授
專長：基因毒理及動物毒理試驗研究 主要教授課程：  大學部：獸醫病理學、中毒學
研究所：動物毒物病理學
Tel：04-22840894 ext406
E-mail：jwliao@dragon.nchu.edu.tw
 
 
簡要學經歷及重要榮譽：
國立嘉義農專獸醫科畢 國立中興大學獸醫學學士  國立中興大學獸醫學碩士 
國立台灣大學獸醫學博士
1989-1991：台灣省農業藥物毒物試驗所助理 
1991-2002：行政院農業委員會農業藥物毒物試驗所助理研究員
2002-2004：行政院農業委員會農業藥物毒物試驗所副研究員
2005-2007：國立中興大學獸醫病理研究所 助理教授 
2007/2-：2009/7-國立中興大學獸醫病理生物學研究所 副教授
2010/8-：國立中興大學獸醫病理生物學研究所教授
 
研究成果簡述：(2013)

1. Chen, YT., Hsuan, SL., Jiann, BP., Chou, CC., Chang, SC., Lee, YF., Chien, MS., Lee, WC., Tsai, FJ., and Liao, JW.* 2013. Effects of sodium citrate on melamine– cyanuric acid mixture-induced urolithiasis in rats. Clinica Chimica Acta 424: 76–82. 
2. Lin, HT, Yen, GC, Huang, TT, Chan, LF, Cheng, YH, Wu, JH^|, Yeh, SD, Wang, SY, and Liao, JW.* 2013.Toxicity assessment of transgenic Papaya Ringspot Virus of 823-2210 line papaya fruits. Journal of Agricultural and Food Chemistry.  61: 1585−1596. 
3. Chen, YT., Wu, JH., Tsai, FJ., Chang YW., Hsu, SH., Lin, JJ., Su, HL., and Liao, JW.* Genotoxicity tests of poly (styrene-co-maleic anhydride)-coated silver nanoparticles by in vivo and in vitro. The Journal of Experimental Nanoscience - Decision on Manuscript ID TJEN-2012-0450.R1 2013. Accepted. 
4. Chang, S.C., Hsuan,  S.L. Lin, C.C. Lee, W.C., Chien, M.S. Chen, L.C. Wu, J.H. Cheng, S.J. Chen, C.L. and Liao, J.W.* 2013. Probable Blastomyces dermatitidis infection in a young rat. Vet. Pathol. 50: 343 - 346., Manuscript ID VET-11-CR-0266.)
5. Yang CC, Lin CC, Liao JW, Yen SK. 2013. Vancomycin-chitosan composite deposited on post porous hydroxyapatite coated Ti6Al4V implant for drug controlled release. Mater Sci Eng C Mater Biol Appl. 2013 May 1;33(4):2203-12. 
6. Chan ST, Yang NC, Huang CS, Liao JW, Yeh SL. 2013. Quercetin enhances the antitumor activity of trichostatin A through upregulation of p53 protein expression in vitro and in vivo. PLoS One. 2013;8(1):e54255.
7. Huang YT, Wen CC, Chen YH, Huang WC, Huang LT, Lin WC, Arulselvan P, Liao JW, Lin SH, Hsiao PW, Kuo SC, Yang NS. 2013. Dietary uptake of Wedelia chinensis extract attenuates dextran sulfate sodium-induced colitis in mice. 2013. PLoS One. 2013 May 29;8(5):e64152.
8. Chang NY, Chen ZW, Chen TH, Liao JW, Lin CC, Chien MS, Lee WC, Lin JH, Hsuan SL. 2013. Elucidating the role of ApxI in hemolysis and cellular damage by using a novel apxIA mutant of Actinobacillus pleuropneumoniae serotype 10. J Vet Sci. 2013 Jun 30.
9. Lee CC, Lai YT, Chang HT, Liao JW, Shyu WC, Li CY, Wang CN. 2013. Inhibition of high-mobility group box 1 in lung reduced airway inflammation and remodeling in a mouse model of chronic asthma. Biochem Pharmacol. 2013 Oct 1;86(7):940-9. 
10. Wu CT, Huang KS, Yang CH, Chen YC, Liao JW, Kuo CL, Chen CL, Lo SF, Hsieh CC, Tsay HS. 2013. Inhibitory effects of cultured Dendrobium tosaense on atopic dermatitis murine model. Int J Pharm. 2013 Aug 16. doi:pii:

S0378-5173(13)00737-0. 10.1016/j.ijpharm.2013.08.015. [Epub ahead of print]

11. Wang HC, Chu FH, Chien SC, Liao JW, Hsieh HW, Li WH, Lin CC, Shaw JF, Kuo YH, Wang SY. 2013. Establishment of the metabolite profile for an Antrodia cinnamomea Health Food Product and Investigation of its chemoprevention activity. J Agric Food Chem. 2013 Aug 30. [Epub ahead of print].
12. Li CH, Liao JW, Liao PL, Huang WK, Tse LS, Lin CH, Kang JJ, Cheng YW. 2013. Evaluation of acute 13-week subchronic toxicity and genotoxicity of the powdered root of Tongkat Ali (Eurycoma longifolia Jack). Evid Based Complement Alternat 2013:102987. 
13. Muthuraj, G.V., Kumar, K.J. S., Liao, J.W., Chien, S.C., Mau, J.L., Chiang, S.S., Kuo, Y.H., and Wang, S.Y.. 2013. Antcin C from Antrodia cinnamomea protects liver cells against free radical-induced oxidative stress and apoptosis in vitro and in vivo through Nrf2-dependent mechanism. Evidence-Based Complementary and Alternative Medicine. Accepted. 
14. Tseng, LP, Juan CY, Lin, SL, Doran, MR, Lin, JJ, Hsu, SH, Liao, JW, Shen, CI and Su, HL.* 2013 Nanohybrids of silver particles on clay platelets delaminate Pseudomonas biofilms. Nanomedicine (Lond) (accepted) 
15. Kumar, K.J.S., Vani, MG., Liao, JW, Wang, SY., Hsu, LS., Yang, HL., Hseu Y.C. ^*.2013. In Vitro and In Vivo studies disclosed the depigmenting effects of gallic acid: An emerging candidate for hyperpigmentary skin diseases. Biofactors (2013). Accepted. 
16. Chen, T.L., Liao ,J.W., Chan, W.H., Hsu, C.Y,. Yang, J.D., and Ueng, T.H.* 2013. Induction of cardiac fibrosis and transforming growth factor-β1 by motorcycle exhaust in rats. Inhal Toxicol. 25(9):525-35.
17. Chao, Jung, Liao, J.W., Peng, W.H., Lee, M.S., Pao, L.H., Cheng, H.Y. *. 2013. Antioxidant, analgesic, anti-inflammatory, and hepatoprotective effects of the ethanol extract of Mahonia Oiwakensis stem. International Journal of Molecular Sciences. 14: 2928-2945. 
18. Dai, MZ, Lin, YL, Lin, HC, Zan, HW, Chang, KT, Meng, HF, Liao, JW, Tsai,

MJ, Cheng, H. 2013. Highly sensitive ammonia sensor with organic vertical nanojunctions for non-invasive detection of hepatic injury. Analytical Chemistry. 85 (6), 3110–3117, Accepted 

19. Chen, YC, WL, Chiu, CY, Liao, JW, Chang, CC, Chang, SC. ^* 2013. Expression of MAGE-A restricted to testis and ovary or to various cancers in dogs. Veterinary Immunology and Immunopathology 153: 26– 34. 

 
 
 
 
Liao, Jiunn-Wang 

Professor, 

Graduate Institute of Veterinary
Pathobiology
Professional specialty:  Toxicology and pathology Courses Taught: 
Undergraduate: Vet. pathology, poisoning Graduate: Toxicologic pathology in animals
Tel：04-22840894 ext 406
       E-mail：jwliao@dragon.nchu.edu.tw
 
Educational Background
Ph.D., Department of Veterinary Medicine, National Taiwan University 
MS, Department of Veterinary Medicine, National Chung-Hsing University 
BS, Department of Veterinary Medicine, National Chung-Hsing University 
BS, Department of Veterinary Medicine, National Cha-Yi University
 
Current Position and Professional Career
Professor, Graduate Institute of Veterinary Pathobiology, National Chung Hsing University (2010/8-)
Associate Professor, Graduate Institute of Veterinary Pathobiology, National Chung Hsing University
(2007/2-2010/7)
Assistant Professor, Graduate Institute of Veterinary Pathology, National Chung Hsing University
(2005-2007)
Associate Researcher, Applied Toxicology Department, Taiwan Agricultural Chemicals and Toxic
Substances Research Institute (2002-2004)
Assistant Specialist, Applied Toxicology Department, Taiwan Agricultural Chemicals and Toxic
Substances Research Institute (1991-2002)
Research Assistant, Applied Toxicology Department, Taiwan Agricultural Chemicals and Toxic
Substances Research Institute(1989-1991)
 
Selected Publications (2013)

1. Chen, YT., Hsuan, SL., Jiann, BP., Chou, CC., Chang, SC., Lee, YF., Chien, MS., Lee, WC., Tsai, FJ., and Liao, JW.* 2013. Effects of sodium citrate on melamine– cyanuric acid mixture-induced urolithiasis in rats. Clinica Chimica Acta 424: 76–82. 
2. Lin, HT, Yen, GC, Huang, TT, Chan, LF, Cheng, YH, Wu, JH^|, Yeh, SD, Wang, SY, and Liao, JW.* 2013.Toxicity assessment of transgenic Papaya Ringspot Virus of 823-2210 line papaya fruits. Journal of Agricultural and Food Chemistry.  61: 1585−1596. 
3. Chen, YT., Wu, JH., Tsai, FJ., Chang YW., Hsu, SH., Lin, JJ., Su, HL., and Liao, JW.* Genotoxicity tests of poly (styrene-co-maleic anhydride)-coated silver nanoparticles by in vivo and in vitro. The Journal of Experimental Nanoscience - Decision on Manuscript ID TJEN-2012-0450.R1 2013. Accepted. 
4. Chang, S.C., Hsuan,  S.L. Lin, C.C. Lee, W.C., Chien, M.S. Chen, L.C. Wu, J.H. Cheng, S.J. Chen, C.L. and Liao, J.W.* 2013. Probable Blastomyces dermatitidis infection in a young rat. Vet. Pathol. 50: 343 - 346., Manuscript ID VET-11-CR-0266.)
5. Yang CC, Lin CC, Liao JW, Yen SK. 2013. Vancomycin-chitosan composite deposited on post porous hydroxyapatite coated Ti6Al4V implant for drug controlled release. Mater Sci Eng C Mater Biol Appl. 2013 May 1;33(4):2203-12. 
6. Chan ST, Yang NC, Huang CS, Liao JW, Yeh SL. 2013. Quercetin enhances the antitumor activity of trichostatin A through upregulation of p53 protein expression in vitro and in vivo. PLoS One. 2013;8(1):e54255.
7. Huang YT, Wen CC, Chen YH, Huang WC, Huang LT, Lin WC, Arulselvan P, Liao JW, Lin SH, Hsiao PW, Kuo SC, Yang NS. 2013. Dietary uptake of Wedelia chinensis extract attenuates dextran sulfate sodium-induced colitis in mice. 2013. PLoS One. 2013 May 29;8(5):e64152.
8. Chang NY, Chen ZW, Chen TH, Liao JW, Lin CC, Chien MS, Lee WC, Lin JH, Hsuan SL. 2013. Elucidating the role of ApxI in hemolysis and cellular damage by using a novel apxIA mutant of Actinobacillus pleuropneumoniae serotype 10. J Vet Sci. 2013 Jun 30.
9. Lee CC, Lai YT, Chang HT, Liao JW, Shyu WC, Li CY, Wang CN. 2013. Inhibition of high-mobility group box 1 in lung reduced airway inflammation and remodeling in a mouse model of chronic asthma. Biochem Pharmacol. 2013 Oct 1;86(7):940-9. 
10. Wu CT, Huang KS, Yang CH, Chen YC, Liao JW, Kuo CL, Chen CL, Lo SF, Hsieh CC, Tsay HS. 2013. Inhibitory effects of cultured Dendrobium tosaense on atopic dermatitis murine model. Int J Pharm. 2013 Aug 16. doi:pii:

S0378-5173(13)00737-0. 10.1016/j.ijpharm.2013.08.015. [Epub ahead of print]

11. Wang HC, Chu FH, Chien SC, Liao JW, Hsieh HW, Li WH, Lin CC, Shaw JF, Kuo YH, Wang SY. 2013. Establishment of the metabolite profile for an Antrodia cinnamomea Health Food Product and Investigation of its chemoprevention activity. J Agric Food Chem. 2013 Aug 30. [Epub ahead of print].
12. Li CH, Liao JW, Liao PL, Huang WK, Tse LS, Lin CH, Kang JJ, Cheng YW. 2013. Evaluation of acute 13-week subchronic toxicity and genotoxicity of the powdered root of Tongkat Ali (Eurycoma longifolia Jack). Evid Based Complement Alternat 2013:102987. 
13. Muthuraj, G.V., Kumar, K.J. S., Liao, J.W., Chien, S.C., Mau, J.L., Chiang, S.S., Kuo, Y.H., and Wang, S.Y.. 2013. Antcin C from Antrodia cinnamomea protects liver cells against free radical-induced oxidative stress and apoptosis in vitro and in vivo through Nrf2-dependent mechanism. Evidence-Based Complementary and Alternative Medicine. Accepted. 
14. Tseng, LP, Juan CY, Lin, SL, Doran, MR, Lin, JJ, Hsu, SH, Liao, JW, Shen, CI and Su, HL.* 2013 Nanohybrids of silver particles on clay platelets delaminate Pseudomonas biofilms. Nanomedicine (Lond) (accepted) 
15. Kumar, K.J.S., Vani, MG., Liao, JW, Wang, SY., Hsu, LS., Yang, HL., Hseu

Y.C. ^*.2013. In Vitro and In Vivo studies disclosed the depigmenting effects of gallic acid: An emerging candidate for hyperpigmentary skin diseases. Biofactors (2013). Accepted. 

16. Chen, T.L., Liao ,J.W., Chan, W.H., Hsu, C.Y,. Yang, J.D., and Ueng, T.H.* 2013. Induction of cardiac fibrosis and transforming growth factor-β1 by motorcycle exhaust in rats. Inhal Toxicol. 25(9):525-35.
17. Chao, Jung, Liao, J.W., Peng, W.H., Lee, M.S., Pao, L.H., Cheng, H.Y. *. 2013. Antioxidant, analgesic, anti-inflammatory, and hepatoprotective effects of the ethanol extract of Mahonia Oiwakensis stem. International Journal of Molecular Sciences. 14: 2928-2945. 
18. Dai, MZ, Lin, YL, Lin, HC, Zan, HW, Chang, KT, Meng, HF, Liao, JW, Tsai, MJ, Cheng, H. 2013. Highly sensitive ammonia sensor with organic vertical nanojunctions for non-invasive detection of hepatic injury. Analytical Chemistry. 85 (6), 3110–3117, Accepted 

Chen, YC, WL, Chiu, CY, Liao, JW, Chang, CC, Chang, SC. ^* 2013. Expression of MAGE-A restricted to testis and ovary or to various cancers in dogs. Veterinary Immunology and Immunopathology 153: 26– 34.    
 
 
 
 
中國大陸牛樟芝研究的概况 林志彬

截止 2014 年 3 月中國知網（CNKI）中國期刊全文數據庫收錄農業、醫藥
期刊的牛樟芝（包括牛樟芝）研究論文 140 篇。包括牛樟芝命名和中醫性味、歸經和功效的研究，牛樟芝的段木栽培技术和液體發酵培养技術的研究，化學成分和有效成分的提取研究，牛樟芝的藥理研究，包括其發酵液不同提取物在体外对人慢性粒细胞白血病细胞株 K562 细胞、人前列腺癌 LNCaP 细胞的抑制作用、促進巨噬细胞釋放 NO 的作用及對叠氮鈉(NaN3)損傷的 PC12 神經细胞的修復作用。牛樟芝對化學性肝损傷的保護作用、體内抗腫瘤作用、免疫增强作用以及大鼠 30 天和 90 天安全性評價的研究。
 
 
Overview on the study of Antrodia camphorata in mainland China
LIN Zhi-Bin
 
As of March 2014, total 140 articles of Antrodia camphorate(Zhang Zhi) from medical and agriculture journals listed by CNKI data-base. Nomenclative of Zhang Zhi, and the Xingwei, Guijing and efficacy of Zhangzhi by traditional Chinise medicine(TCM), Wood-cultured technology and liquid fermentation technology  chemical composition and active ingredients were investigated.  Pharmacological effects demonstrated that different extracts of Zhangzhi fermentation broth had  antitumor activity on human chronic myelogenous leukemia cells of K562 and human prostate cancer cell line LNCaP in vitro. Zhangzhi extracts also promoted NO release from macrophage and repaired nerve cell PC₁₂ injuried by sodium azide (NaN3). The protective effect of Zhangzhi on chemical liver injury, the immune-potentiating effect and the anti-tumor effect were observed in vivo. Safety evaluation of 30 days and 90 days was studied in rats.
 
 
 
 Lin Zhi-Bin Current Positions:
Professor, Department of Pharmacology, School of Basic Medical Sciences, Health Science Center, Peking University
 
Education: 1956~1961  
Beijing Medical College(graduated from Faculty of Medicine)
 
Professional Experiences: 
2006~      Honourary Professor, Perm Pharmaceutical Academy, Russia
2000~2002  Visiting Professor, The University of Hong Kong 
1993~1997  Vice President, Beijing Medical University
1993~1995  Professor, School of Medicine, Nan Kai University
1992~1993  Vice Dean, School of Basic Medical Sciences, Beijing Medical
University
1986~1995  Chairman, Department of Pharmacology, Beijing Medical University
1988~      Professor, Department of Pharmacology, Beijing Medical University 
(name changed to Health Science Center, Peking University from April, 2000)
1985~1988  Associate Professor, Department of Pharmacology, Beijing Medical University
1983~1984  Visiting Scholar, College of Pharmacy, University of Illinois at Chicago,  U.S.A.
1979~1985  Lecturer, Department of Pharmacology, Beijing Medical College
1961~1978  Assistant, Department of Pharmacology, Beijing Medical C